Hamideh Pakniat; Khadijeh Elmizadeh; Fatemeh Lalouha; Hojjat Momenzade; Kimia Mahloojian
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background & Objective: The importance of Pap smear in cervical cancer screening is clear. However, yet no organized program has been developed in Iran to screen cervical cancer. Due to the obvious difference in prevalence of cervical cancer in Iran compared to global statistics, it is necessary ...
Read More
Background & Objective: The importance of Pap smear in cervical cancer screening is clear. However, yet no organized program has been developed in Iran to screen cervical cancer. Due to the obvious difference in prevalence of cervical cancer in Iran compared to global statistics, it is necessary to further investigate this issue. As pop smear is the most important factor to decrease the mortality and morbidity of cervical cancer in developed countries, it is important to study the results of abnormal Pap smears and the quality of the report in our region. Materials & Methods: This study was designed retrospectively with reference to the results of Pap smears performed during 3 years from 2016 in the Kosar hospital. The method of collecting samples was census. The results of Pap smears were extracted from the Hospital and 15208 pap smear results were analyzed.Results: From the 15208 women, 15150 had normal cytology results (99.62%) and 58 women had abnormal cytology (0.38%). The frequency of abnormal cytology was 0.246% (n=37) for atypical squamous cell of undetermined significance (ASCUS), 0.08% (n=12) for low-grade squamous intraepithelial lesion (LSIL), 0.006% (n=1)for ASC cannot exclude high-grade intraepithelial lesion (ASC-H), 0.046% (n=7) for high-grade squamous intraepithelial lesion(HSIL), 0.006 (n=1)for atypical glandular cells (AGC), and 0% (n=0) for invasive cancer. No SCC was found in this study. Conclusion: The prevalence of all abnormal results was much lower than other studies; However, in terms of prevalence of abnormalities, the ranking was similar to other studies.In order to obtain more accurate results, it is recommended to study other epidemiological regions.
Gynecology Oncology
Akram Ghahghaei-Nezamabadi; Afsaneh Tehranian; Setareh Akhavan; Elahe Rezayof; Nooshan Tajik
Articles in Press, Accepted Manuscript, Available Online from 11 May 2024
Abstract
Background & Objective: Immunosuppression, HPV persistence, and smoking are the main related risk factors of cervical intraepithelial neoplasia (CIN) recurrence. However, age as a basic factor may be a main factor related to CIN recurrence. Therefore, our study aimed to detect the potential role ...
Read More
Background & Objective: Immunosuppression, HPV persistence, and smoking are the main related risk factors of cervical intraepithelial neoplasia (CIN) recurrence. However, age as a basic factor may be a main factor related to CIN recurrence. Therefore, our study aimed to detect the potential role of women's age in CIN recurrence.Materials & Methods: This cross-sectional study was conducted on 329 patients who underwent conization in the gynecology-oncology clinics of Arash and Imam Khomeini hospitals affiliated with Tehran University of Medical Sciences between February 2016 and February 2021.Results: Totally, 329 cases were enrolled in the study. Most women were in their thirties. CIN recurrence was about 10.0% (32 cases). The CIN recurrence rate was 8.9% in women younger than 30, 10.2% in 30-40, 11.3% in 40-50, and 5.6% in 50-60 decades. There was no significant (p-value=0.802) difference in recurrence rate among age groups. There was a significant (p-value=0.023) difference in the frequency of endocervical involvement regarding age category, women aged 40 to 50 had the most frequent marginal involvement with 26.8%, while there was no significant (p-value=0.802) difference in frequency of marginal involvement regards age category.Conclusion: CIN cases with age higher than 40 years need to have more caution and tight follow-up visit after conization.
Gynecology Oncology
Jorge Cea García; Francisco Márquez Maraver; Inmaculada Rodríguez Jiménez; Laura Ríos-Pena; M. Carmen Rubio Rodríguez
Volume 9, Issue 2 , March and April 2024, , Pages 185-200
Abstract
Background & Objective: We aimed to compare sexual function and body image among cervical cancer survivors.Materials & Methods: Between August 1, 2016 and January 31, 2019, we conducted a prospective study with 104 participants. The FSFI and the FACT-Cx v.4.0 (B4 and C7) were the measurement ...
Read More
Background & Objective: We aimed to compare sexual function and body image among cervical cancer survivors.Materials & Methods: Between August 1, 2016 and January 31, 2019, we conducted a prospective study with 104 participants. The FSFI and the FACT-Cx v.4.0 (B4 and C7) were the measurement tools.Results: Forty–seven and twelve hundredths percent reported sexual activity, with the surgical group considerably less sexually active than the non-surgical group (63% vs. 100%, P=0.0003). Throughout the follow-up, we found no significant changes in sexual function (P>0.05). A diagnosis of sexual dysfunction was made in 60.58% of cervical cancer survivors, 80.65% following surgery alone, and in 100% after radiotherapy and chemotherapy. In comparison with survivors who did not receive radiotherapy, irradiated survivors had lower FSFI total scores (1.2 vs. 21.4, P T1=0.0001; 2.1 vs. 21.75, P T2=0.0002). In comparison with the non–chemotherapy group, the chemotherapy group's scores were considerably lower (1.2 vs. 21.15, P T1 <0.0001; 2.4 vs. 18.95, P T2=0.004). We detected no significant changes in body image scores (P=0.184). Except for T1 time assessment (2 vs. 3, P T1=0.016), no differences in body image between the surgical and non-surgical groups were found throughout the follow-up (P T2=0.992; P T3=0.207; P T4=0.139).Conclusion: The rate of female sexual dysfunction was 60.58%, prevailing after therapeutic multimodality, radiotherapy, and chemotherapy. Throughout the follow–up, we discovered no significant changes in sexual activity and function, or in body image. In terms of body image, there were no significant differences between the surgical and non–surgical groups.
Gynecology Oncology
Jorge Cea García; M. Carmen Rubio Rodríguez; Francisco Márquez Maraver; Laura Ríos-Pena; Inmaculada Rodríguez Jiménez
Volume 9, Issue 2 , March and April 2024, , Pages 201-211
Abstract
Background & Objective: Sexual dysfunction is the symptom with the greatest negative impact on the quality of life of cervical cancer survivors. However, the evaluation of sexual function is challenging, and there is ongoing debate concerning its determinants. We aimed to identify predictive ...
Read More
Background & Objective: Sexual dysfunction is the symptom with the greatest negative impact on the quality of life of cervical cancer survivors. However, the evaluation of sexual function is challenging, and there is ongoing debate concerning its determinants. We aimed to identify predictive variables for sexual function after cervical cancer treatment.Materials & Methods: One hundred and four cervical cancer survivors participated in a prospective cohort study that we carried out employing FACT–Cx v.4.0 and FSFI questionnaires.Results: We developed a beta generalized linear model with a predictive accuracy of 78% (C–index=0.78) and based on vaginal shortening (Cx4) (P=0.077), age (P=0.0002), and ovarian preservation (P=0.01) as risk factors, and functional well–being (P<0.0001) and follow–up duration (P=0.015) as protective factors.Conclusion: To the best of our knowledge, we may have created the first reliable and internally validated prediction model for cervical cancer survivors based on predictors like vaginal shortening, age, ovarian preservation, functional well–being, and follow–up duration that significantly affect female sexual function as targets for potential intervention.