Sedigheh Borna; Nasim Khorami; Azin Ghamari; Fahimeh Ghotbizadeh Vahdani
Volume 4, Issue 1 , March and April 2019, , Pages 24-28
Abstract
Background & Objective: This prospective study aimed to determine the relationship between maternal and amniotic fluid (AF) lipid profiles in the second trimester with pregnancy outcomes.
Materials & Methods: One hundred-eighty singleton pregnant women, with a gestational age of 16-22 weeks, ...
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Background & Objective: This prospective study aimed to determine the relationship between maternal and amniotic fluid (AF) lipid profiles in the second trimester with pregnancy outcomes.
Materials & Methods: One hundred-eighty singleton pregnant women, with a gestational age of 16-22 weeks, were enrolled in this study. All women underwent amniocentesis, and 2 mL of AF was investigated for AF lipid profile. Furthermore, the serum maternal lipid profile was evaluated simultaneously. All participants were followed up until the delivery, and postnatal outcomes were recorded.
Results: Mean maternal age and body mass index (BMI) of all participants were 5.8±33 years and 25.6±2.8 kg/m2, respectively. Mean maternal estriol, cholesterol, and triglyceride levels, as well as mean cholesterol and triglyceride levels of AF, were significantly different between term and preterm; intrauterine growth retardation (IUGR) and non-intrauterine growth retardation (non-IUGR); and low birth weight and normal weight neonates (P < /em><0.001). The AF cholesterol level was an independent predictor of term or preterm delivery, while the maternal estriol level was an independent predictor of IUGR or normal growth.
Conclusion: Maternal and amniotic fluid lipid profiles could be good indicatives of fetus growth.
Sedigheh Borna; Hajiehe Borna; Fahimehe Gotbizadeh; Mahnaz Jahani
Volume 1, Issue 3 , November and December 2016
Abstract
Background: Progesterone is a smooth muscle relaxant and also has a vasodilator effect on human placental arteries and veins.
Objectives: The aim of this study was to evaluate the effect of progesterone therapy on fetal Doppler velocimetry in intrauterine growth retardation (IUGR) and preterm fetuses.
Methods: ...
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Background: Progesterone is a smooth muscle relaxant and also has a vasodilator effect on human placental arteries and veins.
Objectives: The aim of this study was to evaluate the effect of progesterone therapy on fetal Doppler velocimetry in intrauterine growth retardation (IUGR) and preterm fetuses.
Methods: Thirty pregnant females with IUGR and thirty pregnant females with threatened preterm labor at 28 to 37 weeks of gestation were enrolled in the clinical trial study. Fetal Doppler velocimetry was investigated before, 24 hours and two weeks after progesterone therapy. Seven patients with IUGR and 9 patients with preterm labor were excluded from the study before completion of the survey due to the termination of pregnancy.
Results: Following progesterone treatment, middle cerberal arterypulsatility index (MCA_PI) significantly decreased after 24 hours in patients with IUGR and after two weeks in patients with preterm labor (P < 0.001). There was not a statistically significant decrease in the pulsatility index of the fetal umbilical artery (UmA) after 24 hours in the IUGR fetuses (P = 0.18). Umbilical artery pulsatility index (UmA_PI) significantly decreased after two weeks in IUGR fetuses (P < 0.004).
Conclusions: Progesterone led to a reduction in the MCA_PI and UmA_PI in IUGR and preterm fetuses. Vasodilatory effect of pro gesterone on the umbilical artery is mediated by multiple doses in IUGR fetuses.
