Gynecology Oncology
Batool Hossein Rashidi; Marjan Ghaemi; Ensieh Shahrokh Tehrani; Marzieh Mohebbi; Marzieh Savari
Volume 8, Issue 5 , September and October 2023, , Pages 446-456
Abstract
Background & Objective: Preserving fertility in women with cancer before therapeutic interventions is very important. This study was evaluating the 8 years’ experience of an onco-fertility center from 2013 to 2020 on fertility preservation and its outcomes in female cancer survivors.Materials ...
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Background & Objective: Preserving fertility in women with cancer before therapeutic interventions is very important. This study was evaluating the 8 years’ experience of an onco-fertility center from 2013 to 2020 on fertility preservation and its outcomes in female cancer survivors.Materials & Methods: Participants were females with an approved cancer diagnosis of reproductive ages that were referred for fertility preservation. After proper counseling by an expert team, the final decision on the fertility preservation method was made based on the patient's condition and survival expectation. The primary goal was to collect data about the fertility, clinical and survival outcomes of these women and pregnancy rate as a secondary objective that were compared between cancer types.Results: Totally 337 participants were recruited with a mean±SD age of 30.7±6.6 years. Gynecological cancers accounted for 166 (49.3%) of all cases followed by breast (107 (31.8%)) and other cancers (64 (19.0%)) respectively. Of those, 144 (42.7%) cases entered into the ovulation induction cycle and the others did not continue due to lack of correct information and late referral, and inability to postpone treatment as the major reasons. Comparing between 3 groups (gynecological, breast and other cancers), a higher rate of pregnancy otherwise not statistically different was detected in gynecological cancer survivors. In the breast cancer survivors, the chance of oocyte retrieval and fertility was not lower than in other cancers.Conclusion: Many patients and even their therapists are unfamiliar with the methods of fertility preservation, and when they consider it, the golden time is usually passed. Therefore, having a good consultation with the survivors and patient education may be the most important issue that led to a timely referral for preserving fertility in cancer patients.
Maternal Fetal Medicine
Mahboobeh Shirazi; Mohammadreza Zarkesh; Maliheh Fakehi; Marjan Ghaemi
Volume 7, Issue 4 , March and April 2022, , Pages 329-334
Abstract
Background & Objective: This study aimed to compare the neonatal outcomes and infant development one year after birth at different gestational ages of elective cesarean section (CS) beyond 38 weeks.Materials & Methods: This retrospective cohort study was recruited in an academic hospital affiliated ...
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Background & Objective: This study aimed to compare the neonatal outcomes and infant development one year after birth at different gestational ages of elective cesarean section (CS) beyond 38 weeks.Materials & Methods: This retrospective cohort study was recruited in an academic hospital affiliated with Tehran University of Medical Sciences between June 2018 and June 2020. The subjects of the study were the women who were scheduled for elective CS and divided into 3 groups according to the gestational age (38 0/7 to 38 6/7 as group A, 39 0/7 to 39 6/7 as group B, and 40 0/7 to 40 6/7 as group C). The neonatal outcomes and the growth and development status were evaluated by ages and stages questionnaires® (ASQ) after 12 months and compared between groups.Results: Totally, 952 neonates were eligible for this study. In groups A, B, and C, CS was performed in 314, 409, and 229 neonates, respectively. The first minute Apgar was significantly lower in the neonates with lesser gestational age at delivery (P < /em>=0.026). Indeed, neonatal hospitalization, hypoglycemia, and jaundice in group A were significantly higher than in other groups (P < /em><0.001). Regarding psychomotor development, the scores related to gross motor and problem-solving abilities in group A were significantly lower than those in other groups (P < /em><0.05).Conclusion: It is suggested to plan elective CS beyond 39 weeks of gestation to decrease prenatal morbidities and improve psychomotor development one year after birth.
Obstetrics and Gynecology
Mahboobeh Shirazi; Mehnoosh Torkzaban; Samira Fallah; Marjan Ghaemi
Volume 7, Issue 1 , September and October 2021, , Pages 20-24
Abstract
Background and Objective: Pain is the most common side effect of induced medical abortion. However, the optimal analgesia method remains as a clinical challenge. This study aimed to compare the efficacy of two methods of administration of diclofenac as a prophylactic or a therapeutic in pain management ...
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Background and Objective: Pain is the most common side effect of induced medical abortion. However, the optimal analgesia method remains as a clinical challenge. This study aimed to compare the efficacy of two methods of administration of diclofenac as a prophylactic or a therapeutic in pain management in induced second-trimester medical abortion. Materials and Methods: This randomized clinical trial study was conducted upon pregnant women who were candidates for induced medical abortion and referred to a tertiary educational hospital between October 2019 and December 2020. Participants were divided into two groups based on the mode of diclofenac administration, which was either simultaneously with the first dose of misoprostol or after beginning of the pain. Pain severity, induction-to-abortion time interval, total misoprostol dosage, Hemoglobin concentration, length of hospitalization, and size of retained pregnancy products by ultrasound, and the cumulative dose of opioid usage were compared between the groups.Results: The severity of pain which was measured by a visual analog scale (VAS), residual of conceived products, hospitalization days, and the total misoprostol dosage were significantly lower (P < /em><0.05) in the prophylaxis compared to the treatment group.Conclusion: Simultaneous administration of diclofenac with misoprostol as prophylactic method of pain management may be an optimal method in induced medical abortion in the second trimester.
Maternal Fetal Medicine
Seddighe Borna; Marjan Ghaemi; Fatemeh Golshahi; Mamak Shariat; Mahboobeh Shirazi; Behrokh Sahebdel
Volume 5, Issue 4 , December 2020, , Pages 159-166
Abstract
Background & objective: Premature preterm rupture of membrane (PPROM) is a cause of preterm birth. This study investigated the effectiveness of Doppler ultrasound in predicting fetal complications and neonatal outcomes of pregnant women with PPROM.Materials & Methods: In this cross-sectional ...
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Background & objective: Premature preterm rupture of membrane (PPROM) is a cause of preterm birth. This study investigated the effectiveness of Doppler ultrasound in predicting fetal complications and neonatal outcomes of pregnant women with PPROM.Materials & Methods: In this cross-sectional study, a total of 23 pregnant women with PPROM were chosen in their 24 to 34 weeks of gestational age. The fetuses’ blood flow indices were evaluated by Doppler ultrasound pulsatility index (PI) in the middle cerebral, main pulmonary, right kidney, and fetal umbilical arteries and descending aorta at admission (because of PPROM) and 24 hours before delivery. Neonatal outcomes were assessed within the first week of birth.Results: The kidney artery PI increased (P < /em>=0.047) and pulmonary artery PI decreased (P < /em>=0.024) at pregnancy termination time. There was a negative correlation between the 5-minute Apgar score and fetal umbilical artery PI at admission (P < /em>=0.003) and pregnancy termination times (P < /em>=0.031). The fetal umbilical artery PI of neonates with abnormal brain ultrasound imaging results significantly decreased at admission (P < /em>=0.002) and pregnancy termination times (P < /em>=0.004).Conclusion: Fetal artery Doppler ultrasound PI may be a valid tool for predicting neonatal outcomes of women with PPROM.
Pathology
Bahman Fouladi; Khadijeh Rezaei Keikhaie; Nesa Rajabpoor Nikoo; Salia Amini Poya; Solaiman Saravani; Jebraeil Farzi
Volume 5, Issue 1 , August 2020, , Pages 11-18
Abstract
Background & Objective: Vulvovaginal candidiasis (VVC) is a common vaginal yeast infection in women. The present study aimed to determine the phenotype of Candida albicans and non-albicans Candida species in VVC cases.Materials & Methods: This was a cross-sectional study on 65 patients suspected ...
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Background & Objective: Vulvovaginal candidiasis (VVC) is a common vaginal yeast infection in women. The present study aimed to determine the phenotype of Candida albicans and non-albicans Candida species in VVC cases.Materials & Methods: This was a cross-sectional study on 65 patients suspected of VVC through a visit by a gynecologist. They were cultured on CHROMagar and Sabouraud dextrose agar (SDA). If morphology of the colonies could be detected through microscopic inspection, physiological tests were used to identify individual yeast species.Results: Out 65 colonies, 53.8% had negative cultures. The frequency of positive cultures for Candida were also calculated (C. albicans = 38.5%, C. glabrata = 6.15%, and C. krusei = 1.53%). Most of culture-negative cases had no history of antibiotic therapy (94.3%) while most of culture-positive cases had a history of fluconazole therapy (56% in C. albicans isolates and 40% in non-C. albicans isolates). Relapse rate was calculated as 29.2%. Of studied patients, 80% had no underlying disease, 15.4% had a history of diabetes, and 4.6% had a history of corticosteroid therapy. Less than half negative-culture cases had an undergraduate degree (45.7%).Conclusion: The incidence of VVC depends on various factors including occupation, underlying disease and history of antibiotic therapy. The most common cause of VVC is C. glabrata, secondary to C. albicans. Relapse infection rates can be reduced by increasing knowledge on clinical data, underlying diseases, mechanism of the organism, cause of infection, and effective treatment.
Khadije Rezaei keykhaei; Nesa Rajabpour Nikoo; Hamid Vaez; Leili Rezaei keikhaei; Mahboobeh Shirazi; Marjan Ghaemi; Soleiman Saravani; Sanaollah Raeiszadeh; Asadollah Rezaei
Volume 4, Issue 4 , September and October 2019, , Pages 141-145
Abstract
Background & Objective: Mycoplasma hominis, which belongs to the Mycoplasmataceae family, is an opportunistic pathogen of the genitourinary system. Mycoplasma genitalium, causing urethritis-endometritis-cervicitis, plays a role in prostatitis This study aimed to investigate the prevalence of M. genitalium ...
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Background & Objective: Mycoplasma hominis, which belongs to the Mycoplasmataceae family, is an opportunistic pathogen of the genitourinary system. Mycoplasma genitalium, causing urethritis-endometritis-cervicitis, plays a role in prostatitis This study aimed to investigate the prevalence of M. genitalium and M. hominis among women with vaginal infection in Zabol, Iran.
Materials & Methods: In this cross-sectional study, 69 endocervical samples were taken from women aged 18 to 60 years who suffered from vaginal infections. DNAs extracted from the samples were applied as a template for 16SrDNA coding gene amplification using specific primers in two separate PCR reactions.
Results: The highest infection rate was in the age group of 25 to 35 years, with a prevalence of 75%. The highest rate of negative PCR results (54%) was in the age group of 25 to 35 years, followed by the age groups of 36 to 45 years (28%), 18 to 24 years (4%), and older than 45 years (3%). The lowest rate was in the age group younger than 18 years (2%). Considering their levels of education, the highest rate of infection was seen in the subjects with bachelor’s degrees. The rate of Mycoplasma genitalium infection was equal in the subjects who had and did not have a miscarriage (50%). Only 5.7% of the subjects with negative PCR samples had a miscarriage and the rest (94.3%) did not experience a miscarriage.
Conclusion: Overall, the present study showed that the rate of Mycoplasma vaginal infections was very low Also there is no significance deference for infection rate between pregnant women with or without miscarriage history. However, those with Mycoplasma-negative PCR samples had a low miscarriage rate.
