Pathology
Nasrin Ziamajidi; Nazi Moini; Hiva Danesh; Roghayeh Abbasalipourkabir; Nahid Radnia; Zeinab Barartabar
Articles in Press, Accepted Manuscript, Available Online from 05 September 2023
Abstract
Background & Objective: Breast cancer has the highest incidence of all cancers and the incidence of this disease is increasing rapidly in many countries around the world, including Iran. In this study, some epidemiological and pathological factors have been investigated in breast cancer patients.Methods: ...
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Background & Objective: Breast cancer has the highest incidence of all cancers and the incidence of this disease is increasing rapidly in many countries around the world, including Iran. In this study, some epidemiological and pathological factors have been investigated in breast cancer patients.Methods: This is a cross-sectional study which contains 476 patients with a confirmed diagnosis of breast cancer, was conducted in Tehran, Dr. Moini Breast Clinic from 2019 to 2021. Results: The mean age of patients was 50.2±11.40 years, of which 80.9% patients over 40 years. Ductal carcinoma was the most common in terms of histology (81.7%) and most patients are in grade 2 (63.6%). According to hormonal receptors, 73.8% of women had estrogen receptor positive and 68.9% of women had progesterone receptor positive and 18.9% of patients were triple negative. There is a significant relationship between grade and lymph node involvement (P-value=0.00) and also a significant relationship between metastasis with grade (P-value = 0.00 (and metastasis with lymph node involvement (P-value = 0.00) was seen.Conclusion The results of this study show that breast cancer has a high prevalence in Iranian women in Tehran, mainly seen in the 4th and 5th decades of breast cancer. HER-2 (epidermal growth factor 2 receptor overexpression) and triple negatives were the least subgroups. Considering that diagnosis happens late and about 63.6% of patients are in grade 2, it is necessary to implement programs in the field of screening and prevention in the female population of this province.
Obstetrics and Gynecology
Aida Mohamadi; Mahsa Ghajarzadeh; Fatemeh Davari Tanha; Amirreza Azimi
Articles in Press, Accepted Manuscript, Available Online from 21 December 2023
Abstract
Background: Women with multiple sclerosis (MS) suffer from a wide range of complications. The goal of this study was to compare sexual dysfunction (SD), depression, and sexual quality of life in women with MS with these problems in women without MS.
Methods: Fifty-four women with MS and 108 women without ...
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Background: Women with multiple sclerosis (MS) suffer from a wide range of complications. The goal of this study was to compare sexual dysfunction (SD), depression, and sexual quality of life in women with MS with these problems in women without MS.
Methods: Fifty-four women with MS and 108 women without MS were enrolled. All participants were asked to fill valid and reliable versions of BDI (Beck Depression Inventory), FSFI (Female Sexual Function Index), and SQOL (sexual quality of life) questionnaires.
Results: Mean scores for BDI, SQOL, and orgasm and satisfaction domains of FSFI were significantly different between case and control groups. Sexual quality of life (SQOL) had a significant positive correlation with FSFI (r=0.568, p<0.001) and a significant negative correlation with BDI scores (r=-0.528, p<0.001). A significant negative correlation was also found between FSFI and BDI scores (r=-0.325, p<0.001). According to the total FSFI cut-off point, 53.7% of cases and 44.4% of controls had SD (p=0.168).
Considering SQOL as a dependent variable and age, education level, marriage duration, husband’s age, and BDI and FSFI scores as independent variables, linear regression analysis showed that education level, BDI score, and FSFI score were independent predictors of SQOL in all participants, while among MS patients, only BDI and FSFI were significant predictors of SQOL.
Conclusion: Sexual quality of life and sexual function should be considered in women with MS, and depression should be assessed and treated as a possible risk factor.
Gynecology Oncology
Roya Dolatkhah; Mehrnaz Hosseinalifam; Zohreh Sanaat; Neda Dolatkhah; Saeed Dastgiri
Volume 8, Issue 5 , September and October 2023, , Pages 422-430
Abstract
Breast cancer (BC) was the most common cancer in Iran, accounting for 12.9% of all incident cancer, and was the 5th leading cause of cancer death in 2020. The latest age standardized incidence rate (ASIR) of breast cancer was 35.8 in Iran and is expected to increase to more than 70 per 100,000 by the ...
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Breast cancer (BC) was the most common cancer in Iran, accounting for 12.9% of all incident cancer, and was the 5th leading cause of cancer death in 2020. The latest age standardized incidence rate (ASIR) of breast cancer was 35.8 in Iran and is expected to increase to more than 70 per 100,000 by the end of 2030. Incidence of breast cancer had a clustering pattern in Iran, while central provinces had the highest ASIR (72 per 100,000 population), and South East provinces had the lowest ASIR (5-11 per 100,000 population). Numerous studies have shown that the peak incidence of breast cancer was occurred in the age group of 40-49 years in Iran. There has also been reported a rapid increase in the incidence in young women from different regions of the country. Known molecular and cellular processes involved in the development of breast cancer in Iranian BCs have been reported from various studies in recent decades, and the most well-known and prominent genes susceptible to breast cancer were BRCA1 and BRCA2. They acted as tumor suppressor genes and inherited mutations leading to chromosomal instability. However, non-coding RNAs, epigenetic alterations, signaling pathways, immune responses, and antioxidant-related genes are the main molecular processes associated with the progression of breast cancer among Iranian patients. While we are facing a significant increase in the incidence of breast cancer, with a lower survival rate, breast cancer is currently considered as one of the major health problems in Iran, which emphasizes the importance of providing and designing prevention and early detection program of breast cancer.
Obstetrics and Gynecology
Mitra Modares Gilani; Azam Sadat Mousavi; Setareh Akhavan; Shahrzad Sheikhhasani
Volume 7, Issue 6 , September and October 2022, , Pages 530-535
Abstract
Background & Objective: Cervical cancer is one of the most common cancers in women. One of the most important indicators that deal with all aspects of the patients' health is the Health-related quality of life (QOL). In this study, the QOL of women with cervical cancer in Iran was investigated.Materials ...
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Background & Objective: Cervical cancer is one of the most common cancers in women. One of the most important indicators that deal with all aspects of the patients' health is the Health-related quality of life (QOL). In this study, the QOL of women with cervical cancer in Iran was investigated.Materials & Methods: The present cross-sectional study examined the QOL of 139 patients with cervical cancer referred to Imam Khomeini hospital, affiliated with the Tehran University of Medical Sciences. For this study, a specific questionnaire of QOL in patients with cervical cancer was used. To determine the predictors of cervical cancer patients, the QOL linear regression model was used.Results: Findings of this study showed that the total score of QOL of patients was 20.97±1.29. Moreover, in the regression model, a significant relationship was observed between the type of treatment and patients' QOL scores and those patients who had neoadjuvant therapy plus surgery (β=-17.45, P < /i>=0.02) and those who received brachytherapy (β=- 14.86 and P < /i>=0.09) had a significantly lower QOL score.Conclusion: Overall, the QOL of people with cervical cancer was moderate. Implementing educational programs for service providers and choosing the appropriate type of treatment according to the stage of the disease and the patient's age can help control this type of disease and its complications and improve the QOL of patients.
Obstetrics and Gynecology
Nasibeh Roozbeh; Sepideh Hajian; Soodabeh Darvish; Zahra Kiani
Volume 7, Issue 3 , January and February 2022, , Pages 131-143
Abstract
Background & Objective: Given the significant role of low birth weight (LBW) in infant death and disability and relevant childhood diseases, the present systematic review was conducted to determine the factors affecting newborns’ birth weight in Iran.Materials & Methods: This study ...
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Background & Objective: Given the significant role of low birth weight (LBW) in infant death and disability and relevant childhood diseases, the present systematic review was conducted to determine the factors affecting newborns’ birth weight in Iran.Materials & Methods: This study systematically reviewed all the observational studies carried out in Iran between 1990 and 2021 (retrieval date: April 28, 2021) in four steps and through searches in Persian databases (including Magiran, SID, and IranDoc) and English databases (including Embase, Cochrane Library, Web of Sciences, Google Scholar, PubMed, and Scopus). All the relevant articles were searched by two researchers separately and collected using research keywords, Boolean operators, and a combination of relevant tags depending on the type of database. The quality of the articles was evaluated with 22-item Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) and Ottawa checklists, respectively.Results: Of the 251 articles collected, 31 met the study inclusion criteria. Variables such as the mother’s age (35%), body mass index (BMI) (25%), preterm childbirth, and diagnosis with a maternal chronic disease (25%) were found to be the most common causes of LBW in the reviewed studies, by order of prevalence.Conclusion: Based on the results of this review study and given that many of the known risk factors of LBW are preventable, the timely diagnosis, proper treatment, and follow-up of women at risk can prevent the birth of LBW infants.
Obstetrics and Gynecology
Mahbod Kaveh; Venus Hajaliakbari; Fateme Davari-Tanha; Shokoh Varaei; Mahsa Ghajarzadeh; Elham Feizabad; Mohammad Ali Ashraf; Zahra Kaveh
Volume 7, Issue 2 , September and October 2021, , Pages 69-76
Abstract
Background & Objective: The recent surge in coronavirus disease 2019 (COVID-19) cases has exposed health care workers (HCWs) to a wide range of psychological stressors and predisposed them to anxiety-related disorders. In this study, we observed the anxiety level in this population.Materials & ...
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Background & Objective: The recent surge in coronavirus disease 2019 (COVID-19) cases has exposed health care workers (HCWs) to a wide range of psychological stressors and predisposed them to anxiety-related disorders. In this study, we observed the anxiety level in this population.Materials & Methods: This multicenter, cross-sectional study was performed on 1,038 HCWs in 14 hospitals of Tehran during the COVID-19 pandemic. In May 2020, Beck Anxiety Inventory (BAI) was used to measure the level of anxiety in this population.Results: The mean±SD age of participants was 36.30±8.23 years old. Most participants were 31 to 40 years old (43.2), female (87.6%), and nurses (49.5%). The BAI scores of the participants were in a positive skew distribution, with a score range of 0-63, a median of 12, and a mean value of 15.30±11.43. Out of 1,038 hospital staff, 411 (39.6%) had moderate to severe anxiety. The anxiety level was significantly higher in HCWs ≤40 years old, women, and nurses. However, there was no significant relationship between stress levels among frontline workers compared to second-line workers (P < /em>=0.82).Conclusion: It seems that HCWs experienced a high level of anxiety in the COVID-19 outbreak. One of the critical measures in every epidemic is to provide supportive care to maintain the mental well-being of HCWs, especially in high-risk groups, including younger HCWs, women, and nurses.
Sedigheh Abdollahpour; Talat Khadivzadeh
Volume 4, Issue 3 , September and October 2019, , Pages 86-92
Abstract
Background & Objective: Traumatic childbirth, followed by postpartum stress, imposes many psychological consequences on women and their families. Therefore, this study was conducted to determine the prevalence of traumatic childbirth and postpartum post-traumatic stress in Iran using a systematic ...
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Background & Objective: Traumatic childbirth, followed by postpartum stress, imposes many psychological consequences on women and their families. Therefore, this study was conducted to determine the prevalence of traumatic childbirth and postpartum post-traumatic stress in Iran using a systematic review.
Materials & Methods: In this review, ISI, PubMed, Scopus, SID, Iranmedex, IranDoc, Magiran, and Google Scholar databases were searched to find relevant studies, by looking for the following keywords, i.e., prevalence, traumatic childbirth, post-traumatic stress, post-traumatic stress disorder, delivery or birth, Iran, and their English equivalents, in Persian and English-language journals published from 1981 to November 2018. Data were analyzed by the meta-analysis method using a random-effects model and the studies’ heterogeneity was calculated by the I2 index.
Results: Of a total of 1420 studies, 8 descriptive studies carried out from 2010 to 2017 were finally included after applying the inclusion and exclusion criteria. Among the 800 samples studied, the overall prevalence of traumatic childbirth was 51.3% and the overall prevalence of post-traumatic stress was 29.1% among the total of 2687 samples studied.
Conclusion: The prevalence of traumatic childbirth and post-traumatic stress is high in Iran; hence, it is necessary to carry out further studies to understand this important issue, so that more attention can be paid to mothers’ psychological problems to plan and make policies to maintain and improve their health in the postpartum period.
maliheh Arab; shahla Noori Ardabili; poria Ganji
Volume 3, Issue 1 , March and April 2018, , Pages 39-44
Abstract
Introduction Endometrial cancer is one of the most common malignancies in women globally. The laparoscopic approach from endometrial cancer is suggested in the medical literature. The aim of the present review is to clarify clinical points of laparoscopic operation in endometrial cancer. A search using ...
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Introduction Endometrial cancer is one of the most common malignancies in women globally. The laparoscopic approach from endometrial cancer is suggested in the medical literature. The aim of the present review is to clarify clinical points of laparoscopic operation in endometrial cancer. A search using keywords included endometrial carcinoma, and treatment and laparoscopy were conducted on PubMed, Up-To-Date, Ovid and Clinical Key databases up to 2016.
Conclusion This present review research showed over 1600 full-text manuscripts, of which, 18 were relevant to this article. The laparoscopic approach to endometrial cancer is categorized as follows: 1) Comparison of complications and advantages of laparoscopy and laparotomy in endometrial cancer; 2) Hospitalization days; 3) Blood transfusion and blood loss; 4) Comparison of the operation time of laparoscopy versus laparotomy; 5) Conversion of laparoscopy to laparotomy; 6) Comparison of endometrial cancer lymphadenectomy in laparoscopy with laparotomy; 7) Laparoscopy of endometrial cancer in old age; 8) Surgical experience and learning curve; 9) Technical points in laparoscopic endometrial cancer surgery; 10) Comparison of endometrial cancer survival in laparoscopy and laparotomy methods; 11) Cost issues.
Atefe Moridi; Maliheh Arab; Farzaneh Jamdar; Donya Khosravi; Ghazaleh Fazli
Volume 2, Issue 3 , September and October 2017
Abstract
Lymphedema is an unusual and specific type of peripheral edema resulting from obstruction or disruption of lymphatic system. The present review was conducted on PubMed, UpToDate, and ClinicalKey databases before 2016. The keywords included lymphedema or leg edema AND advanced malignancy. The primary ...
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Lymphedema is an unusual and specific type of peripheral edema resulting from obstruction or disruption of lymphatic system. The present review was conducted on PubMed, UpToDate, and ClinicalKey databases before 2016. The keywords included lymphedema or leg edema AND advanced malignancy. The primary review revealed 104 full text publications, of which 24 relevant articles were selected and another 17 relevant articles from the reference list of the selected articles were added, as well. Practical points in diagnosis and treatment of lymphedema in gynecologic malignancies are presented in the below subtitles: -basic descriptions, classifications, and epidemiology; -clinical presentation and diagnostic tests; -differential diagnosis; -non-surgical management; -surgical management.
Mehdi Yousefi; Malihe Hasanzadeh; Vesam Rostaminezhad; Maryam Gaffarean; Azam Sadat Mousavi
Volume 2, Issue 1 , March and April 2017
Atefeh Moridi; Maliheh Arab; Ghazaleh Fazli; Maryam Khayamzadeh
Volume 1, Issue 3 , November and December 2016
Abstract
Dermoid cyst is a benign and common ovarian neoplasm affecting women. Sources for this review article were taken from PubMed and other up-to-date databases covering the period from Jan 2010 to Jan 2016. Keywords for the search were “dermoid cyst” and “treatment”. A search of the ...
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Dermoid cyst is a benign and common ovarian neoplasm affecting women. Sources for this review article were taken from PubMed and other up-to-date databases covering the period from Jan 2010 to Jan 2016. Keywords for the search were “dermoid cyst” and “treatment”. A search of the literature revealed 113 full text manuscripts, from which 21 were relevant. In addition, another 56 relevant manuscripts identified in the reference lists of the above-mentioned 21 manuscripts were included in the study, although they had been published before 2010. Clinical considerations for dermoid cyst management are categorized as follows: 1) selection of the best choice of surgical treatment in dermoid cyst: laparoscopy or laparotomy; 2) procedure to exteriorize a dermoid cyst in laparoscopy; 3) selection of oophorectomy or cystectomy; 4) spillage of the cyst contents: prevention and treatment of the consequences if it does happen; 5) necessity of surgical treatment in dermoid cyst management; 6) ovarian torsion and other complications; 7) Probability of malignancy in dermoid cyst.