Obstetrics and Gynecology
Alfonsus Zeus Suryawan; Amillia Siddiq
Articles in Press, Accepted Manuscript, Available Online from 09 November 2023
Abstract
Background: Uncertainities exist about the diagnostic and prognostic role of hemocytometry values in patients with COVID-19 especially in pregnancy. This study aims to investigate hemostatic changes in pregnant woman with coronavirus disease (COVID-19) and their relationship to disease severity.Methods: ...
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Background: Uncertainities exist about the diagnostic and prognostic role of hemocytometry values in patients with COVID-19 especially in pregnancy. This study aims to investigate hemostatic changes in pregnant woman with coronavirus disease (COVID-19) and their relationship to disease severity.Methods: This research is an analytic observational study with case control design. Subject was gathered from Hasan Sadikin General Hospital patients medical records from June 2021 – March 2022. Inclusion criteria on this study is all pregnant COVID-19 patient with Prothrombin time (PT), activated partial thromboplastin time (aPTT), and D-dimer examination. The exclusion of this study all pregnant COVID-19 patient without required examination. PT, aPTT, and D-dimer were measured by Stago kits on a Stago automated coagulation analyzer (STA Compact Max®). Data was then analyzed by Kruskal Wallis with IBM SPSS Statistic 26th with α=0.05.Results: Statistical analysis shows there’s corelation between different severity levels with D-Dimer. This study shows mean of D-Dimer of each severity levels; asymptomatic 4.85 mg/L, mild 2.86 mg/L, moderate 5.47 mg/L and severe 14.51 mg/L (p <0.000). Changes seen after mild group which increase to 5,47 mg/dL in moderate COVID-19 and furthermore increase in severe become 14,51 mg/L. No changes in PT and aPTT was found.Conclusion: In conclusion, our findings demonstrate that coagulopathy is associated with the severity of COVID-19 illness. D-dimer is important parameter for evaluating the COVID-19 severity in pregnancy. This further could serve as diagnostic category to differ the severity of COVID-19 in pregnancy.
Maternal Fetal Medicine
rana razavi; samira jahangard
Volume 7, Issue 1 , September and October 2021, , Pages 52-58
Abstract
Pregnant women appear to be more severely affected by COVID-19. Coagulopathy is known as one of the most challenging effects of COVID-19, and the effects of acute airway diseases resulting from the coronavirus on pregnant mothers and their fetuses can be dangerous. Two women who where pregnant suffering ...
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Pregnant women appear to be more severely affected by COVID-19. Coagulopathy is known as one of the most challenging effects of COVID-19, and the effects of acute airway diseases resulting from the coronavirus on pregnant mothers and their fetuses can be dangerous. Two women who where pregnant suffering from coagulopathy (one of them with disseminated intravascular coagulation (DIC) and the other one with hypercoagulation) and COVID-19 infection are reported in this study. During hospitalization due to severe vaginal bleeding and placental detachment, cesarean section was performed on the first caseand because of acute severe DIC, she received a massive transfusion. The second patient epigastric pain and tachycardia. COVID-19 might have a variety of effects on pregnancy outcome, from vascular and placental involvement to respiratory involvement; there is an association between the coronavirus and hyper-coagulopathy state and coagulopathy like DIC.