General Gynecology and Pelvic Floor
Rihab Majeed Shareef; Najah Shaker Yassen; Sallama Hamid Alkhudair
Articles in Press, Accepted Manuscript, Available Online from 13 November 2023
Abstract
Background: Melatonin play a role in pubertal development and reproductive function through the Hypothalamus-hypophysis-gonadal axis. In addition, melatonin production decreases with age, so that indolamine could be an anti-ageing agent. To assess Intra follicular melatonin level's role in ovarian ...
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Background: Melatonin play a role in pubertal development and reproductive function through the Hypothalamus-hypophysis-gonadal axis. In addition, melatonin production decreases with age, so that indolamine could be an anti-ageing agent. To assess Intra follicular melatonin level's role in ovarian reserve and the IVF cycle outcomes.
Patients and method: A prospective cross-sectional study was conducted from April 2022 to April 2023. Patients on a mini-long agonist, short agonist, and antagonist protocols were enrolled in the current study. Using ultrasound, the follicle development was observed from the stimulation day until the hCG day (done every 2 or 3 days).
Results: Melatonin were positively correlated with oocyte retrieved (r=0.705, P<0.001), number of fertilized oocyte (r=0.68, P<0.001), number of zygotes cleaved (r=0.660, P<0.001), high quality embryos (r=0.591, P<0.001), embryos for transplantation (r=0.604, P<0.001), percent of high quality embryos (r=0.58, P<0.001), and with percent of blastocyst rate.
Conclusion: Melatonin mean levels in follicular fluid were significantly decreased in poor response than in standard and high response. The follicular fluid melatonin levels were associated with each oocyte quantity and quality and can expect ICSI consequences and act as highly important biochemical indicators of ovarian reserve.
Obstetrics and Gynecology
shereef elshwaikh; Ahmed Ossman; muhammad el-masry; ahmed swelam; yasmin elmasry
Articles in Press, Accepted Manuscript, Available Online from 24 December 2023
Abstract
Aim: To evaluate changes in serum AMH levels, fertility and metabolic conditions in reproductive-age severely obese women, after bariatric surgery.
Design: prospective cohort study.
Methods: This study had been conducted on marked obese women who were referred to BS in Tanta university hospital. the ...
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Aim: To evaluate changes in serum AMH levels, fertility and metabolic conditions in reproductive-age severely obese women, after bariatric surgery.
Design: prospective cohort study.
Methods: This study had been conducted on marked obese women who were referred to BS in Tanta university hospital. the AMH and other hormones (FSH- LH- free Testosterone- SHBG- fasting Insulin) levels had been measured as part of their evaluation will be reviewed before and after (6) months the surgery. The involved women were in reproductive age between 18 and 40 years old. With BMI > 36 kg/m2 and < 42 kg/m2.
Results: From 64 female who had been enrolled, 50 patients only completed the 6 months follow up , and it was found there was a significant difference as regard the weight and the BMI , fasting insulin level and regular menstrual pattern after 6 month follow but other fertility factors including were improved but had no significant difference .
Also 20 cases (40%) had a spontaneous ovulation after 6 moth follow up after BS , and by comparing them to those who had no spontaneous ovulation ,there was a significant effect on weight reduction on occurrence of spontaneous ovulation , BMI parameter, and the level of change of BMI, regular menstrual cycle, while the other fertility related parameters although improved but failed to show any significant relationship .
Conclusion: BS and reduction of the weight had a positive effect on the reproductive performance of obese female.
Gynecology Oncology
Batool Hossein Rashidi; Marjan Ghaemi; Ensieh Shahrokh Tehrani; Marzieh Mohebbi; Marzieh Savari
Volume 8, Issue 5 , September and October 2023, , Pages 446-456
Abstract
Background & Objective: Preserving fertility in women with cancer before therapeutic interventions is very important. This study was evaluating the 8 years’ experience of an onco-fertility center from 2013 to 2020 on fertility preservation and its outcomes in female cancer survivors.Materials ...
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Background & Objective: Preserving fertility in women with cancer before therapeutic interventions is very important. This study was evaluating the 8 years’ experience of an onco-fertility center from 2013 to 2020 on fertility preservation and its outcomes in female cancer survivors.Materials & Methods: Participants were females with an approved cancer diagnosis of reproductive ages that were referred for fertility preservation. After proper counseling by an expert team, the final decision on the fertility preservation method was made based on the patient's condition and survival expectation. The primary goal was to collect data about the fertility, clinical and survival outcomes of these women and pregnancy rate as a secondary objective that were compared between cancer types.Results: Totally 337 participants were recruited with a mean±SD age of 30.7±6.6 years. Gynecological cancers accounted for 166 (49.3%) of all cases followed by breast (107 (31.8%)) and other cancers (64 (19.0%)) respectively. Of those, 144 (42.7%) cases entered into the ovulation induction cycle and the others did not continue due to lack of correct information and late referral, and inability to postpone treatment as the major reasons. Comparing between 3 groups (gynecological, breast and other cancers), a higher rate of pregnancy otherwise not statistically different was detected in gynecological cancer survivors. In the breast cancer survivors, the chance of oocyte retrieval and fertility was not lower than in other cancers.Conclusion: Many patients and even their therapists are unfamiliar with the methods of fertility preservation, and when they consider it, the golden time is usually passed. Therefore, having a good consultation with the survivors and patient education may be the most important issue that led to a timely referral for preserving fertility in cancer patients.
Obstetrics and Gynecology
Khadije Rezaie Keikhaie; Mania Kaveh; Fatemeh Bahrami; Kambiz Sadegi; Atefeh Kamali; Mahdi Afshari
Volume 6, Issue 3 , June 2021, , Pages 110-115
Abstract
Background & Objective: Anti-mullerian hormone indicates ovarian reserve. The objective of this study was to compare the changes of AMH level following two methods of laparoscopic cystectomy in order to evaluate ovarian reserve in patients with endometrioma.Materials & Methods: To this end, ...
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Background & Objective: Anti-mullerian hormone indicates ovarian reserve. The objective of this study was to compare the changes of AMH level following two methods of laparoscopic cystectomy in order to evaluate ovarian reserve in patients with endometrioma.Materials & Methods: To this end, 86 patients with endometrioma were selected on the basis of inclusion and exclusion criteria, divided into two groups, and subjected to laparoscopic cystectomy. The mean hormone levels were measured before and after surgery and the changes were compared between the two groups using the repeated measures tests. The data were also analyzed using the SPSS 22.Results: The mean number of childbirth was 2.06 in patients with a standard deviation of 1.64. Out of 86, 42 patients (48.8%) were treated with complete removal of cysts and the rest underwent partial removal. The length of cysts in patients undergoing complete removal was significantly larger than that in patients with partial removal (P < /em>=0.011), while the width of cysts was not significantly different between the two groups of patients (P < /em>=0.084). The AMH levels in patients undergoing complete removal significantly decreased from 2.22 before surgery to 1.96 after surgery (P < /em><0.001). The AMH levels in patients undergoing partial removal was also decreased from 2.47 before surgery to 2.14 after surgery, representing a statistically significant difference (P < /em><0.001).Conclusion: Regarding the results of the study, the type of ovarian cyst removal has not any effect on after-surgery consequences.
