Obstetrics and Gynecology
Minthami Sharon
Volume 8, Issue 5 , September and October 2023, , Pages 514-519
Abstract
Background & Objective: Obstructive sleep apnoea (OSA) is characterised by repeated episodes of upper airway obstruction resulting in hypoxemia, hypercapnia and sleep fragmentation. It is intriguing to consider the consequences of these events on pregnancy outcomes. This study was conducted ...
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Background & Objective: Obstructive sleep apnoea (OSA) is characterised by repeated episodes of upper airway obstruction resulting in hypoxemia, hypercapnia and sleep fragmentation. It is intriguing to consider the consequences of these events on pregnancy outcomes. This study was conducted to determine the prevalence of obstructive sleep apnoea among pregnant women and its association with pregnancy outcomes.Materials & Methods: It has been found that subjects belonging to the age group 21-25 years had increased sleep disturbances and reduced quality of sleep. Also, pregnant women in the first trimester were found to have poor quality sleep.Results: Pregnancy outcomes associated with OSA were found as high chance of caesarean section, gestational diabetes mellitus, Gestational hypertension, low birth weight and APGAR<7.Conclusion: Hence, early detection and its prevention can improve the pregnancy outcomes.
Maternal Fetal Medicine
Ali Reza Norouzi; Mahsa Siavashi; Fatemeh Norouzi; Maryam Talayeh; Somayyeh Noei Teymoordash
Volume 6, Issue 4 , August 2021, , Pages 217-223
Abstract
Background & Objective: Gestational diabetes mellitus (GDM) is the most prevalent disorder during pregnancy, which is the result of insulin resistance and hyperinsulinemia due to the secretion of placental diabetogenic hormones. This study aimed to investigate the utility of glycated hemoglobin ...
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Background & Objective: Gestational diabetes mellitus (GDM) is the most prevalent disorder during pregnancy, which is the result of insulin resistance and hyperinsulinemia due to the secretion of placental diabetogenic hormones. This study aimed to investigate the utility of glycated hemoglobin A1c (HbA1c) alone and in combination with hematocrit for early detection of gestational diabetes mellitus.Materials & Methods: In this prospective cohort research, 373 pregnant women who referred to prenatal clinics were included. Hematocrit and HbA1c were determined at gestational age of 12 to 16 weeks and compared with the oral glucose tolerance test (OGTT) results at gestational age of 24-28 weeks.Results: The best cut-off hematocrit for determining pregnancy diabetes mellitus was 37.3. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 70.15%, 64.12%, 32.71 %, and 89.51% respectively.In terms of HbA1c, the best cut-off value to determine GDM in pregnant women was 5, with a sensitivity of 98.51%, specificity rate of 99.02%, PPV of 95.07%, and NPV of 99.49%. In terms of diagnosing GDM, the area under the ROC curve (AUC) for HbA1c was equal to 0.985 which was higher than the AUC for the combination of HbA1c with HCT.Conclusion: Measuring HbA1c can be useful as a screening test for GDM, which is an inexpensive and available test. The combined evaluation of HbA1c and hematocrit did not improve the diagnostic value of HbA1c in GDM screening compared to exclusive evaluation of HbA1c.
