Gynecology Oncology
Forozan Milani; Seyedeh Hajar Sharami; Negar Gholamalipour; Ehsan Kazemnezhad Leyli; Seyedeh Fatemeh Dalil Heirati; Yalda Donyaei-Mobarrez
Volume 9, Issue 1 , January and February 2024, , Pages 53-62
Abstract
Background & Objective: Evaluation of the alpha-fetoprotein is one of the screening tests during pregnancy. The purpose of this study was to determine the relationship between the level of alpha-fetoprotein in amniotic fluid (AF-AFP) and adverse pregnancy outcomes.Materials & Methods: This ...
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Background & Objective: Evaluation of the alpha-fetoprotein is one of the screening tests during pregnancy. The purpose of this study was to determine the relationship between the level of alpha-fetoprotein in amniotic fluid (AF-AFP) and adverse pregnancy outcomes.Materials & Methods: This comparative analytical study was performed on 244 pregnant women who referred to a private prenatal clinic in Rasht (Iran). Amniocentesis was performed on pregnant women with maternal serum alpha-fetoprotein (MS-AFP) was higher than 2.5MoM in the second trimester and based on this finding, participants were divided into four groups of 61 patients. The first group (control group) included pregnant women with normal MS-AFP, the second group included pregnant women with high MS-AFP and normal AF-AFP, the third group included pregnant women with high MS-AFP and low AF-AFP and the fourth group included pregnant women with high MS-AFP and high AF-AFP.Results: Adverse outcomes include abortion (6.6%), stillbirth (6.6%), IUGR (18%), LBW (29.5%), PTL (21.3%), fetal abnormalities (4.9%), preeclampsia (14.8%), gestational diabetes (8.2%), in the fourth group (high AF-AFP) was higher than other groups. The incidence of adverse pregnancy outcomes in the fourth group was 1.2 times higher than the control group, and this relationship was borderline statistically significant (P=0.056).Conclusion: Considering that adverse pregnancy outcomes are important causes of mortality and morbidity, early diagnosis of high-risk pregnancies and efforts for preventive interventions can be associated with reducing mortality and morbidity. Therefore, evaluation of the level AF-AFP can be helpful in determining adverse pregnancy outcomes.
Sedigheh Borna; Nasim Khorami; Azin Ghamari; Fahimeh Ghotbizadeh Vahdani
Volume 4, Issue 1 , March and April 2019, , Pages 24-28
Abstract
Background & Objective: This prospective study aimed to determine the relationship between maternal and amniotic fluid (AF) lipid profiles in the second trimester with pregnancy outcomes.
Materials & Methods: One hundred-eighty singleton pregnant women, with a gestational age of 16-22 weeks, ...
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Background & Objective: This prospective study aimed to determine the relationship between maternal and amniotic fluid (AF) lipid profiles in the second trimester with pregnancy outcomes.
Materials & Methods: One hundred-eighty singleton pregnant women, with a gestational age of 16-22 weeks, were enrolled in this study. All women underwent amniocentesis, and 2 mL of AF was investigated for AF lipid profile. Furthermore, the serum maternal lipid profile was evaluated simultaneously. All participants were followed up until the delivery, and postnatal outcomes were recorded.
Results: Mean maternal age and body mass index (BMI) of all participants were 5.8±33 years and 25.6±2.8 kg/m2, respectively. Mean maternal estriol, cholesterol, and triglyceride levels, as well as mean cholesterol and triglyceride levels of AF, were significantly different between term and preterm; intrauterine growth retardation (IUGR) and non-intrauterine growth retardation (non-IUGR); and low birth weight and normal weight neonates (P < /em><0.001). The AF cholesterol level was an independent predictor of term or preterm delivery, while the maternal estriol level was an independent predictor of IUGR or normal growth.
Conclusion: Maternal and amniotic fluid lipid profiles could be good indicatives of fetus growth.
