Maternal Fetal Medicine
Parichehr Pooransari; Mahboobeh Shirazi
Volume 5, Issue 2 , October 2020, , Pages 68-71
Abstract
Background & Objective: Screening tests for common aneuploidy, especially trisomies 21, 18, and 13, should be offered to pregnant people of all ages at first and second trimesters. Theses include combined tests (nuchal translucency (NT)+biochemical pregnancy-associated plasma protein-A (PAPP-A), ...
Read More
Background & Objective: Screening tests for common aneuploidy, especially trisomies 21, 18, and 13, should be offered to pregnant people of all ages at first and second trimesters. Theses include combined tests (nuchal translucency (NT)+biochemical pregnancy-associated plasma protein-A (PAPP-A), free beta-human chorionic gonadotropin (β-hCG)) and quad test. If the tests are positive based on cut-off value of 1:250, diagnostic tests such as amniocentesis and chorionic villus sampling (CVS) are suggested. The current study aimed to comparatively evaluate the results of these screening tests and amniocentesis.
Materials & Methods: This practical-basic study was designed to evaluate the accuracy of first and second trimester screening tests with amniocentesis results. A total of 45 subjects were selected from the patients referred for abnormal screening tests toShohadaya-ye-Tajrish hospital in Tehran, Iran, during 2014-2015. The results of tests (combined or quad) were positive based on cut-off value of 1:250. Data was collected through a questionnaire containing such information as age, gravidity, previous aneuploidy births, placenta location, blood group, amniotic fluid color, type of sampling needle, and mode of needle entrance.Results: The mean age of patients was 33.16 years. There was significant p-value between positive results of amniocentesis and age of the patients. Out of 45 amniocentesis tests, four had abnormal results (two in the first trimester (2/17) and two in the second trimester (2/24)). Also, three items were T21 and the forth was translocation between chromosome 11-22. We had one fetal loss due to amniocentesis procedure.Conclusion: Diagnostic tests are suggested for better evaluation of abnormal results. These screening tests have false positive and negative results. We attempted to evaluate the real results with invasive tests. Further research is needed to investigate the accuracy of screening aneuploidy tests.
Mahboobeh Shirazi; Soheila Sarmadi; Shirin Niromanesh; Fatemeh Rahimi Sharbaf; Behrokh Sahebdel; Fatemeh Golshahi; Leila Asadi; Maedeh Rahmanzadeh
Volume 4, Issue 1 , March and April 2019, , Pages 12-15
Abstract
Background & Objective: Diagnosing fetal disorders and abnormalities in the early stages of pregnancy can prevent future adverse conditions for the infant and his/her family. This study aimed to evaluate the sensitivity and specificity of the first- and second-trimester screening tests for identifying ...
Read More
Background & Objective: Diagnosing fetal disorders and abnormalities in the early stages of pregnancy can prevent future adverse conditions for the infant and his/her family. This study aimed to evaluate the sensitivity and specificity of the first- and second-trimester screening tests for identifying fetal chromosomal disorders in pregnant women.
Materials & Methods: A total of 960 pregnant women participated in this retrospective cohort study that was performed at Yas Hospital. The participants’ mean age was 31.07±0.17 years. In the present study, all pregnant women, who referred to Yas Hospital for their first- and second-trimester screening tests, were studied from 2015 to 2017.
Results: Most of the participants (43.4%) were primigravida. The sensitivity of the first-trimester screening test was 70%, and its specificity was 80.3%. The sensitivity and specificity of the second-trimester screening test were 45% and 94.5%, respectively.
Conclusion: Despite recent advances in the prenatal field, the accuracy of screening tests may still vary depending on maternal age and other existing characteristics. Consequently, in parents consulting, the possibility of false positives and negatives should be considered in the tests.
