Obstetrics and Gynecology
Dhai Abdulalazize Rashid; Fadia Jassim Alizzi
Volume 8, Issue 3 , May and June 2023, , Pages 233-239
Abstract
Background & Objective: Infertility that cannot be explained by anovulation, poor sperm quality, tubal disease, or any other recognized cause of infertility is referred to as unexplained infertility. The aim of this study is to assess the correlation between integrin alpha-v beta-3 expression, ...
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Background & Objective: Infertility that cannot be explained by anovulation, poor sperm quality, tubal disease, or any other recognized cause of infertility is referred to as unexplained infertility. The aim of this study is to assess the correlation between integrin alpha-v beta-3 expression, endometrial thickness and subendometrial blood flow resistance index in unexplained infertility.Materials & Methods: The study carried out on Kamal – Al-Samurai fertility center in the period from October 2020 - September 2021. Six days after detecting urinary Luteinizing Hormone (LH) surge, all the women were asked to come to do two-dimensional (2D) transvaginal ultrasound to assess endometrial thickness and subendometrial blood flow color Doppler resistance index and endometrial samples was taken and examined immunohistochemically to detect alpha-v beta-3 integrin. The cut-off value of integrin and subendometrial blood flow resistance index, sensitivity and specificity were calculated by applying Receiver Operative Characteristics (ROC) curve.Results: The endometrial thickness was lower and resistance index was higher in case group (P < 0.001). The expression of integrin alpha-v beta-3 in infertile group was significantly low (P < 0.001) with significant positive correlation between integrin score and endometrial thickness (r= -0.708 & P < 0.001) and significant negative correlation between integrin score and subendometrial resistance index (r= -0.786 & P <0.001).Conclusion: Alpha-v beta-3 integrin expressions and endometrial thickness are reduced significantly in mid-luteal phase while the subendometrial blood flow color Doppler resistant index significantly increased, and using them together can possibly be used as a diagnostic predictor of unexplained infertility.
Obstetrics and Gynecology
Roshan Nikbakht; Mahvash Zargar; Farideh Morammezi; Asma Motaharifard; Maryam Seyedtabib
Volume 8, Issue 2 , March and April 2023, , Pages 143-149
Abstract
Background & Objective: Frozen embryo replacement (FER) cycle is a procedure that assists in, in vitro fertilization (IVF) outcome by using the storage and transfer of excess embryos. This study evaluated the success of FER using Spinnbarkeit and endometrial thickness.Materials & Methods: This ...
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Background & Objective: Frozen embryo replacement (FER) cycle is a procedure that assists in, in vitro fertilization (IVF) outcome by using the storage and transfer of excess embryos. This study evaluated the success of FER using Spinnbarkeit and endometrial thickness.Materials & Methods: This cross-sectional study was performed on 97 infertile women at the Imam Khomeini hospital of Ahvaz, from March 2019 to March 2020. Endometrium was prepared with Estradiol valerate from the third day of menstruation and followed by serial vaginal ultrasound till the thickness of the endometrium attained seven millimeters to eight millimeters. The cervical secretions were collected from the external Os and were estimated based on centimeters. Also, endometrial thickness was recorded.Results: no substantial difference between endometrial thickness and spinnbarkeit in the FER cycles with pregnancy outcomes was observed (P>0.05).Conclusion: Some variables such as endometrial thickness, spinnbarkiet, estradiol dose intake, and quality of embryos have no relationship with the success of FER cycles.
