Obstetrics and Gynecology
Soheila Dabiran; Shahla Khosravi; Leila Pourali; Sedigheh Ayati; Zahra Mohaddes Ardebili; Shamim Delavari
Volume 8, Issue 1 , January and February 2023, , Pages 35-40
Abstract
Background & Objective: Delayed childbearing has become a worldwide phenomenon, yet the association between advanced maternal age (AMA ≥35 years) and pregnancy outcomes remains unclear. This issue has also been inadequately explored in Iran. To assess the relationship between pregnancy complications ...
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Background & Objective: Delayed childbearing has become a worldwide phenomenon, yet the association between advanced maternal age (AMA ≥35 years) and pregnancy outcomes remains unclear. This issue has also been inadequately explored in Iran. To assess the relationship between pregnancy complications and AMA in the Iranian context.Materials & Methods: This cross-sectional study involved 891 women who had consecutive pregnancies and were referred for delivery to an academic hospital at Mashhad university of medical sciences, Mashhad , Iran, from March 2015 to March 2019 for The women were considered into the two age groups, namely, a 20 to 34year group and an AMA group, who were then assessed in terms of complications of late childbearing, such as preeclampsia, gestational hypertension, and gestational diabetes mellitus (GDM); mode of delivery; and five-minute Apgar score. The data were analyzed using the chi-square test and the Mann–Whitney U test in SPSS version 9. The P<0.05 was considered statistically significant.Results: The AMA group exhibited lower five-minute Apgar scores and a significantly higher prevalence of preeclampsia, gestational hypertension, and GDM (p < 0.05). The two groups also substantially differed concerningquality of prenatal care (p < 0.001). Regarding the mode of delivery, cesarean section was more prevalent in the AMA group, whereas vaginal delivery was more common in the younger group (p < 0.001).Conclusion: With regard to trend to pregnancy in higher maternal age and higher pregnancy complication in this population, precise preconception counseling is crucial to educating couples for early childbearing at younger age.
Obstetrics and Gynecology
Nooshin Amjadi; Nasrin Mansori; Leili Rezaie Kahkha; Mojtaba Ashrafi; Saeedeh Chalaki; Khadije Rezaie Keikhaie
Volume 7, Issue 5 , July and August 2022, , Pages 445-451
Abstract
Background & Objective: Diabetes Mellitus refers to a group of specific metabolic diseases with a hyperglycemic phenotype. The present study compares pregnancy outcomes and nonstress tests (NST) in insulin-treated diabetic women with healthy pregnant women.Materials & Methods: In this cross-sectional ...
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Background & Objective: Diabetes Mellitus refers to a group of specific metabolic diseases with a hyperglycemic phenotype. The present study compares pregnancy outcomes and nonstress tests (NST) in insulin-treated diabetic women with healthy pregnant women.Materials & Methods: In this cross-sectional study, pregnancy outcomes and NST results were evaluated in 45 diabetic pregnant women who had received insulin therapy and 90 healthy pregnant women. The NST tracings of all women were applied and evaluated regarding reactive and non-reactive parameters. Data were analyzed using SPSS software version 20 and Fisher's exact test.Results: Our results demonstrated that NST was reactive in 75.6%and was non-reactive in 24.4% of diabetic mothers. There was a significant increase in macrosomia in diabetic mothers with non-reactive NST, while there was no statistical significance between NST results in the two groups. Conclusion: Pregnant women with diabetes are more prone to complications than healthy women. The main complication is the fetal size which leads to difficulties in delivery and increased incidence of cesarean section.
Maternal Fetal Medicine
Mona Taghavipour; Tahereh Galini-Moghaddam; Seyed Jaber Mousavi
Volume 6, Issue 1 , January 2021, , Pages 22-28
Abstract
Background and Objectives: Maternal serum levels of the first- and second-trimester markers for aneuploidy have been revealed to be associated with adverse pregnancy outcomes in the absence of neural tube defects or aneuploidy. This finding can guide clinicans for early diagnosis and management of such ...
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Background and Objectives: Maternal serum levels of the first- and second-trimester markers for aneuploidy have been revealed to be associated with adverse pregnancy outcomes in the absence of neural tube defects or aneuploidy. This finding can guide clinicans for early diagnosis and management of such outcomes. However, previous finding are conflicting in this regard. Therefore, this study evaluated the detection of adverse pregnancy outcomes by first- and second-trimester serum screening analytes.Methods & Materials: We prospectively recruited 972 females who underwent first and second-trimester aneuploidy screening. We gathered information on maternal demographic characteristics and serum biomarkers (free B-hCG and PAPP-A for the first-trimester; AFP, Β-hCG, Inhibin-A, and unconjugated estradiol for second-trimester). At the end of the study, adverse pregnancy outcome was recorded.Results: Abnormal screening results were reported in 34 (3.5%) patients. Two groups were significantly different in maternal age, BMI, and gestational period (P < /em>=0.017, 0.003 and 0.021, respectively). Among the measured adverse outcomes, preeclampsia was significantly more prevalent in the case group (P < /em><0.0001). Abnormal levels of Inhibin-A is associated with the incidence of preeclampsia (RR: 29.87, CI: 13.22-67.49, P < /em><0.0001). Additionally, patients with an abnormal level of Inhibin-A had a shorter gestational period (255.5 ± 24.53 vs. 264.79 ± 8.99, P < /em>=0.006). Likewise, patients with an abnormal level of maternal serum alpha-fetoprotein (MSAFP) had a shorter gestational period (252.0 ± 29.3 vs. 264.8 ± 8.93, P < /em>=0.001).Conclusion: First- and second-trimester maternal serum biomarkers could provide a possible screening tool for early detection of preeclampsia.
