Gynecology Oncology
Maha Saad Maki; Mohammed S. Ali; Hala Rawi
Articles in Press, Accepted Manuscript, Available Online from 03 March 2024
Abstract
Background: assess the level of serum Macrophage inhibitory cytokine-1 and high sensitive C - reactive protein level in the first trimester threatened miscarriage.
Method: We conducted a case-control study on 91 pregnant women who were in their first trimester and had a positive fetal heart confirmed ...
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Background: assess the level of serum Macrophage inhibitory cytokine-1 and high sensitive C - reactive protein level in the first trimester threatened miscarriage.
Method: We conducted a case-control study on 91 pregnant women who were in their first trimester and had a positive fetal heart confirmed by ultrasound. On the same day, a serum sample was taken to measure the levels of macrophage inhibitory cytokine-1 and high-sensitivity C-reactive protein using an enzyme-linked immunosorbent assay and particle-enhanced immunoturbidimetric assay, respectively. The study grouped the participants into two categories: control and patient.
Result: We conducted a study with 91 pregnant women, out of which 30 had symptoms of threatened miscarriage such as vaginal spotting or bleeding, while the remaining 61 were healthy. In our study, we found that the concentration levels of serum Macrophage inhibitory cytokine-1 varied significantly between the two groups (control and patient groups) with a P-value of 0.005. The mean concentration for the control group was 622.77 ± 15.10, while for the patient group, it was 1860.13 ± 33.60. Additionally, we observed that high-sensitivity c-reactive protein (HS CRP) had a significant correlation with threatened miscarriage, with a P-value of 0.001. The mean concentration for the control group was 7.49 ± 0.89, while for the patient group, it was 16.02 ± 2.11.
Conclusion: The results of this study provide valuable insights into the pathophysiology of miscarriage and may pave the way for the development of novel therapeutic interventions to prevent this adverse pregnancy outcome.
Obstetrics and Gynecology
Mahsa Naemi; Maasoumeh Saleh; Mahboubeh Saleh
Volume 8, Issue 2 , March and April 2023, , Pages 125-130
Abstract
Background & Objective: Preeclampsia (PE) is a major complication of pregnancy worldwide. Doppler ultrasound of maternal arteries, including uterine and ophthalmic arteries (OA), plays an important role in determining individuals progressing PE. The aim of this study is to compare OA indices ...
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Background & Objective: Preeclampsia (PE) is a major complication of pregnancy worldwide. Doppler ultrasound of maternal arteries, including uterine and ophthalmic arteries (OA), plays an important role in determining individuals progressing PE. The aim of this study is to compare OA indices in pregnant women with a diagnosis of PE and women without it.Materials & Methods: This study evaluated pregnant women who had delivery in Shariati Hospitals, Tehran, Iran between January 2021 and March 2022. The maternal OA Doppler waves were obtained in preeclamptic and non-preeclamptic women at 35 to 37 weeks of gestation by a maternal-fetal medicine specialist. OA Doppler parameters including first and second PSV, second to first PSV ratio (Peak ratio, PR) and PI were obtained for each eye and also average between the eyes.Results: Out of 148 included participants, 48 cases progressed to PE at 35 to 37 weeks of gestation and 100 cases did not have PE at the same gestational age. All OA parameters including (First and second peak systolic velocities (PSV), second to first PSV Ratio (PR) and Pulsatility Index (PI) in each eye; as well as, the average of these indices in both eyes) were assessed. PR and PI between the two eyes were statistically different in those with PE.Conclusion: OA Doppler indices change in pregnant women with PE. These changes could help to earlier and better diagnosis of PE and prevention of maternal and fetal sequelae.