Obstetrics and Gynecology
Katayoun Haryalchi; Mandana Mansour Ghanaei; Mohammad Rajabi; Maryam Ghazizadeh; Fakhroddin Aghajanpour; Pouya Koochakpoor; Mahmood Abedinzade
Volume 9, Issue 1 , January and February 2024, , Pages 29-35
Abstract
Background & Objective: Studies have shown contradictory results regarding the use of pregabalin and melatonin as analgesic agents. Because the analgesic effects of these drugs as preemptive have not been compared in abdominal hysterectomy, one of the most common surgical procedures in women ...
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Background & Objective: Studies have shown contradictory results regarding the use of pregabalin and melatonin as analgesic agents. Because the analgesic effects of these drugs as preemptive have not been compared in abdominal hysterectomy, one of the most common surgical procedures in women with moderate to severe pain, under general anesthesia. The aim of this study was to compare the pretreatment effects of melatonin and pregabalin on postoperative pain intensity in total abdominal hysterectomy (TAH).Materials & Methods: Ninety Patients were randomly divided into three groups (N=30): the first group received oral melatonin (6 mg), the second group received pregabalin (50 mg), and the third one who took no drug. Serum melatonin and beta-endorphin levels were measured before and after the surgery. Pain intensity was assessed by the Numerical Rating Scale at 1,6,12, and 24 hours after the surgeries.Results: At 12 hrs after the surgery, mean pain intensity in the melatonin group was significantly lower than the pregabalin group, and in the pregabalin group was significantly lower than the third group (P<0.05). At 24 hrs after the TAH, the mean pain intensity in the melatonin group was significantly lower than the third group (P<0.05).Conclusion: Injection preventive melatonin is more effective than pregabalin to reduce pain throughout the first 24 hrs after the TAH.
Obstetrics and Gynecology
Atefeh Kazemi; Vahideh Rashtchi; Masoomeh Ghomi
Volume 8, Issue 6 , November and December 2023, , Pages 556-562
Abstract
Background & Objective: Some types of major surgeries are associated with postoperative pain, sometimes during the days after surgery. These pains mainly lead to the use of various analgesics and, ultimately, patient dissatisfaction. In the present study, we evaluated the effect of gabapentin ...
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Background & Objective: Some types of major surgeries are associated with postoperative pain, sometimes during the days after surgery. These pains mainly lead to the use of various analgesics and, ultimately, patient dissatisfaction. In the present study, we evaluated the effect of gabapentin at doses of 600 and 1200 mg on relieving pain due to cesarean section.Materials & Methods: In this randomized clinical trial, patients were randomly divided into three equal-size groups (25 patients in each group) through balanced block randomization. The first group was given 600 mg of gabapentin, the second group was given 1200 mg of gabapentin one hour before surgery, and the control group received a placebo. The pain intensity, nausea, vomiting, and drowsiness, as well as the need for postoperative analgesics, were assessed initially and at 2, 6, and 12 hours after surgery. The occurrence of nausea and drowsiness between groups was compared using the chi-square and Fisher's exact tests.Results: The mean (SD) age of patients in the gabapentin 1200 mg, gabapentin 600 mg, and placebo groups was 26.32±6.15, 27.43±6.38, and 26.59±5.88, respectively (P=0.34). Pain intensity and the rate of analgesic consumption at different time points during the first 12 hours of surgery were significantly lower in the receiving gabapentin groups than in the placebo group (P<0.05). Comparing the prevalence rates of nausea and vomiting and also drowsiness, as the drug-related side effects don’t show a significant difference across the three groups at the different investigated time points (P>0.05).Conclusion: Gabapentin with a minimum therapeutic dose can successfully reduce postoperative pain intensity and also needs analgesic use after a cesarean section.
General Gynecology and Pelvic Floor
Nahla W. Shady; Hassan A. Farouk; Hany F. Sallam
Volume 7, Issue 5 , July and August 2022, , Pages 391-398
Abstract
Background & Objective: To see if 900 mg of vaginal isonicotinic acid hydrazide (INH) given 12 hours before insertion of a T380A copper intrauterine device (IUD) was more effective than placebo in increasing insertion ease and reducing insertion discomfort in nulliparous ...
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Background & Objective: To see if 900 mg of vaginal isonicotinic acid hydrazide (INH) given 12 hours before insertion of a T380A copper intrauterine device (IUD) was more effective than placebo in increasing insertion ease and reducing insertion discomfort in nulliparous ladies.Materials & Methods: A double-blind, randomized controlled study recruited nulliparous women who wanted to use the Copper IUD for contraception. Women who were WHO-eligible for IUD implantation were recruited and randomly assigned (1:1) to vaginal INH 900 mg or placebo (n=100 in each group), 12 hours before the IUD was placed. The primary endpoint was the ease of insertion for the providers. The number of unsuccessful IUD insertions was also recorded.Results: The groups had similar baseline characteristics. The ease of insertion score in the INH group was lower than in the placebo group (3 (2-5).5 vs. 6 (3-8); P=0.01), indicating that physicians in the INH group had an easier time inserting the device. The INH group had a reduced mean pain score during the procedure (3.97 ± 0.991 vs. 6.42 ± 0.66; P=0.001). In the INH group, two incidences of failed IUD insertion occurred (2%) compared to four cases in the control group (4 percent). 0.594 is the p-value. Conclusion: Self-administered INH 900 mg vaginally 12 hours before a copper T380A IUD insertion successfully reduced discomfort during insertion and improved women's satisfaction and ease of insertion as measured by physicians in nulliparous teenagers and young ladies.
Solmaz Fakhari; Hojjat Pourfathi; Haleh Farzin; Eisa Bilehjani
Volume 3, Issue 4 , November and December 2018, , Pages 137-142
Abstract
Breast cancer is a common type of cancer among female human populations. Approximately, one million new cases are diagnosed per year and it is expected that this amount will increase in the future. In recent years, the common standard surgical procedures for the treatment of breast invasive carcinoma ...
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Breast cancer is a common type of cancer among female human populations. Approximately, one million new cases are diagnosed per year and it is expected that this amount will increase in the future. In recent years, the common standard surgical procedures for the treatment of breast invasive carcinoma are breast-protective surgery and modified radical mastectomy. Residual tumor after surgery, stage T3–T4, metastases to 4 axillary lymph nodes or greater, and extracapsular axillary lymph node disease that is treated with adjuvant chemotherapy are indications of surgery. Post-mastectomy radiotherapy results in an increased disease-free condition and survival rate. With the improvement of survival rate, the procedure has been focused on quality of breast cancer survivors.
Hojjat Pourfathi; Haleh Farzin
Volume 3, Issue 3 , September and October 2018, , Pages 93-97
Abstract
Aims: Postpartum depression is a common event after delivery. Among some possible causes, pain is an important contributing factor which can play role in increasing psychiatric disease. The aim of the present study was to assess the effect of neuraxial analgesia methods on reducing incidence of postpartum ...
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Aims: Postpartum depression is a common event after delivery. Among some possible causes, pain is an important contributing factor which can play role in increasing psychiatric disease. The aim of the present study was to assess the effect of neuraxial analgesia methods on reducing incidence of postpartum depression.
Materials & Methods: 280 pregnant women (140 cases, 140 controls) without depression history who referred for vaginal delivery in the maternity ward of Taleghani teaching hospital, from February 2016 until February 2017 were participated in this randomized clinical trial. Samples were selected by random sampling method. Depression risk was assessed by Edinburgh Postnatal Depression Scale (EPDS) and the pain was measured by Visual Analogue Scale (VAS). Data were analyzed by SPSS 22 using Mann-whitney test and independent t-test for comparing of quantitative mean values. The association between qualitative variables was assessed by Chi square and exact Fisher tests.
Findings: Postpartum depression occurred in the painless delivery group and natural delivery group. There was statistically significant difference between them (p=0.04). It means that depression rate in painless delivery group was lower than natural delivery group. High Edinburg score was associated with high risk of depression.
Conclusion: Postpartum depression in women with painless delivery is lower comparison to women with natural delivery.
Forough Javanmanesh; Maryam Kashanian; Vajihe Zamani; Narges Sheikhansari
Volume 3, Issue 3 , September and October 2018, , Pages 99-103
Abstract
Aims: Pain is the main concern after surgery. Gabapentin was recently suggested as a pain killer to be used after various surgeries. The purpose of the present study was to evaluate the effects of gabapentin on pain relief and need for opiates after total abdominal hysterectomy.
Materials & Methods: This ...
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Aims: Pain is the main concern after surgery. Gabapentin was recently suggested as a pain killer to be used after various surgeries. The purpose of the present study was to evaluate the effects of gabapentin on pain relief and need for opiates after total abdominal hysterectomy.
Materials & Methods: This randomized double-blind placebo-controlled clinical trial was performed on 85 women who underwent total abdominal hysterectomy from March 2014 to March 2016 in Akbarabadi teaching hospital and Firoozgar teaching hospital in Tehran, Iran. Samples were selected using consecutive sampling method and were randomly assigned into the 2 groups. In case group (n=44) gabapentin (800mg) was orally administered one hour before surgery and in the placebo group (n=41) placebo which was similar to gabapentin administered. The pain score was assessed in 2, 6, 12 and 24 hours after surgery. Nausea and vomiting were also compared between the 2 groups. Data were analyzed by SPSS 19 software using statistical tests.
Findings: The two groups did not have significant differences according to pain score in the recovery room (point 0). Mean score of pain was lower in the case group in 2, 6, 12 and 24 hours after surgery (p=0.005). Meperidine (pethidine) use was less in the case group (p=0.003). There was no difference between the 2 groups for nausea and vomiting.
Conclusion: Using gabapentin before surgery can lower the pain after surgery and reduces the need for opiates. However, it doesn’t have an effect on nausea and vomiting.
