Mohammadmahdi Sabahi; Sara Amiahmadi; Rasool Haddadi
Volume 3, Issue 1 , March and April 2018, , Pages 1-7
Abstract
Aims: Various evidences have shown the effect of ovarian hormones on locomotor activities and catalepsy induced by a variety of stimuli. The aim of this study was to evaluate the effects of estrogen and progesterone on catalepsy and motor and balance impairment classified as haloperidol-induced extrapyramidal ...
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Aims: Various evidences have shown the effect of ovarian hormones on locomotor activities and catalepsy induced by a variety of stimuli. The aim of this study was to evaluate the effects of estrogen and progesterone on catalepsy and motor and balance impairment classified as haloperidol-induced extrapyramidal disorders.
Materials and Methods: The current experimental study was performed on 96 female Wistar rats (180-200g). These rats were randomly divided into 16 groups (n=6). Prior to administration of haloperidol, the rats were pretreated with flutamide (10mg/kg, i.p.), estrogen (1mg/kg 17 β-estradiol, s.c.), and/or progesterone (1mg/kg, i.p.) for 1 day or 7 consecutive days. The effects of estrogen and progesterone on haloperidol-induced catalepsy and motor impairment were assessed by a bar test and a rotarod performance test, respectively. Data were analyzed by SPSS 22 software using ANCOVA and Tukey test.
Findings: One to 7-day treatment with estrogen had a protective effect on haloperidol-induced extrapyramidal disorders such that it significantly improved catalepsy and motor impairment in the rats and restored and normalized their motor levels. However, the progesterone administration did not represent significant effects in improving extrapyramidal symptoms and a slight improvement was achieved. The co-administration of flutamide significantly reduced the protective effect of estrogen on catalepsy and motor balance impairment induced by haloperidol.
Conclusion: The deficiency of ovarian hormones increases catalepsy; however, this disorder is more likely to occur due to estrogen insufficiency. Hence, progesterone plays a little role in it. Moreover, the anti-cataleptic effect of ovarian hormones is exerted through affecting androgenic receptors.
Sedigheh Borna; Hajiehe Borna; Fahimehe Gotbizadeh; Mahnaz Jahani
Volume 1, Issue 3 , November and December 2016
Abstract
Background: Progesterone is a smooth muscle relaxant and also has a vasodilator effect on human placental arteries and veins.
Objectives: The aim of this study was to evaluate the effect of progesterone therapy on fetal Doppler velocimetry in intrauterine growth retardation (IUGR) and preterm fetuses.
Methods: ...
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Background: Progesterone is a smooth muscle relaxant and also has a vasodilator effect on human placental arteries and veins.
Objectives: The aim of this study was to evaluate the effect of progesterone therapy on fetal Doppler velocimetry in intrauterine growth retardation (IUGR) and preterm fetuses.
Methods: Thirty pregnant females with IUGR and thirty pregnant females with threatened preterm labor at 28 to 37 weeks of gestation were enrolled in the clinical trial study. Fetal Doppler velocimetry was investigated before, 24 hours and two weeks after progesterone therapy. Seven patients with IUGR and 9 patients with preterm labor were excluded from the study before completion of the survey due to the termination of pregnancy.
Results: Following progesterone treatment, middle cerberal arterypulsatility index (MCA_PI) significantly decreased after 24 hours in patients with IUGR and after two weeks in patients with preterm labor (P < 0.001). There was not a statistically significant decrease in the pulsatility index of the fetal umbilical artery (UmA) after 24 hours in the IUGR fetuses (P = 0.18). Umbilical artery pulsatility index (UmA_PI) significantly decreased after two weeks in IUGR fetuses (P < 0.004).
Conclusions: Progesterone led to a reduction in the MCA_PI and UmA_PI in IUGR and preterm fetuses. Vasodilatory effect of pro gesterone on the umbilical artery is mediated by multiple doses in IUGR fetuses.
