Omarov Nazarbek Bakytbekovich; Ahmed Al-Hili; Duaa Hamid Ali; Aisha Kamal Mahmoud; Entsar Hachim Muhammad; Ahmed S. Abed; Marwa Jabbar Saiwan; Haider Hussain Jlood
Articles in Press, Accepted Manuscript, Available Online from 08 February 2023
Abstract
The present semi-experimental study was conducted in 2019 on 192 Baghdad-based women aged 20 to 60 with active medical records. Two groups of 96 people, intervention and control, were created. The intervention group received training based on the constructs of health belief and stages of change models ...
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The present semi-experimental study was conducted in 2019 on 192 Baghdad-based women aged 20 to 60 with active medical records. Two groups of 96 people, intervention and control, were created. The intervention group received training based on the constructs of health belief and stages of change models to enhance Pap smear screening behavior. The control group participated in routine training on Pap smear screening behavior in health centers from health professionals. The participants completed a questionnaire created by the researchers in the pre-test and post-test stages. For data analysis, version 19 of SPSS statistical software and independent t-tests, paired t-tests, chi-square, and Fisher's exact test were utilized.A p-value of less than 0.05 was deemed statistically significant. Before the educational intervention, there was no significant difference between the two groups in the stages of behavior change (P>0.05). However, after the educational intervention, the intervention group significantly differed from the control group in the Pap smear screening change (P<0.01). Also, based on the paired t-test, the mean scores of the intervention group's knowledge, susceptibility, severity, barriers, and self-efficacy were significant before and after the intervention (P<0.05). After the intervention, the intervention group demonstrated significantly higher Pap smear screening behavior than the control group (P<0.01).The utilization of educational intervention of the stages of change and health beliefs models has proven to be highly effective in bringing individuals to the action stage.
Alsmadi Yaseen Mohammad Ibrahim; Saad Altimimi; Aisha Kamal Mahmoud; Muqdad Hussein Ali; Naseer Mehdi Mohammed; Ruqayah Taher Habash; Ahmed S. Abed; Entsar Hachim Muhammad
Articles in Press, Accepted Manuscript, Available Online from 08 February 2023
Abstract
Background & Objective: Today, the prevalence of cervical cancer in developing societies and its impacts on various body functions, mainly sexual performance, is of particular significance. In order to examine the relationship between sexual function and its domains with different stages of cervical ...
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Background & Objective: Today, the prevalence of cervical cancer in developing societies and its impacts on various body functions, mainly sexual performance, is of particular significance. In order to examine the relationship between sexual function and its domains with different stages of cervical cancer, the present study was conducted.Materials & Methods: Examined in the current study were 284 women with cervical cancer referred to the Baghdad Women's Hospitals and selected randomly. The personal profile form and the female sexual function index (FSFI) were among the research instruments. The data were investigated by statistical software SPSS.23 and the Spearman correlation coefficient test. A p-value of less than 0.05 was deemed statistically significant.Results: The results revealed that 26.8% of women complained of low sexual desire, 43.0% did not receive adequate sexual arousal, and 39.1% experienced deficient vaginal lubrication. Additionally, 46.8% of women did not experience a proper orgasm, 27.8% were dissatisfied with their sexual satisfaction, and 37.0% reported experiencing pain during intercourse. In addition, there was an inverse correlation between the stages of cervical cancer and sexual performance (r= -0.25, P= 0.002), as well as its domains, including sexual desire (r= -0.18, P= 0.02), sexual arousal (r= -0.23, P= 0.004), vaginal lubrication (r= -0.23, P= 0.003), orgasm (r= -0.20, P= 0.009), sexual satisfaction (r= -0.21, P= 0.005), and pain during intercourse (r= -0.26, P= 0.001).Conclusion: The sexual performance of cervical cancer patients is impaired, and the more advanced stages of the disease weaken sexual performance and its domains.
Gynecology Oncology
Fariba Behnamfar; Fatemeh Ahmadi Solush; Tajossadat Allameh
Volume 8, Issue 1 , November and December 2022, , Pages 11-16
Abstract
Background & Objective: Cervical Cancer (CC) is a common cancer which is associated with HPV-infection. The aim of this study is to investigate the risk factors which affects HPV-clearance.Materials & Methods: This study was carried out on women with high risk HPV infection. All the patients ...
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Background & Objective: Cervical Cancer (CC) is a common cancer which is associated with HPV-infection. The aim of this study is to investigate the risk factors which affects HPV-clearance.Materials & Methods: This study was carried out on women with high risk HPV infection. All the patients underwent pap smears and cervical biopsy. Demographic data, marital status, vaccination history and consumption of tobacco, alcohol, opium and oral contraceptive pills were asked through a questionnaire. Results: The results showed that in one year follow-up, 142 (67.1%) patients showed HPV clearance. The HPV clearance decreased by increasing age (P=0.028) or higher CIN grades (P=0.017). In case of parity, there was no significant difference in univariate analysis (P=0.147), but it was significant in multiple logistic regression analysis (95% CI: 0.413-0.941, OR=0624, P= 0.024).Conclusion: It seems that age and cervical histology at the start of HPV infection are the most important factors for HPV clearance.
Gynecology Oncology
Afsaneh Tehranian; Akram Ghahghaei-Nezamabadi; Maryam Motiei Langeroudi; Reyhaneh Aghajani
Volume 8, Issue 1 , November and December 2022, , Pages 53-56
Abstract
Background & Objective: We compared two different methods of visual inspection of the cervix, including Visual inspection of the cervix with acetic acid (VIA) and Visual inspection of the cervix with Lugol's iodine (VILI) in terms of sensitivity and specificity in diagnosis of pre-malignant cervical ...
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Background & Objective: We compared two different methods of visual inspection of the cervix, including Visual inspection of the cervix with acetic acid (VIA) and Visual inspection of the cervix with Lugol's iodine (VILI) in terms of sensitivity and specificity in diagnosis of pre-malignant cervical lesions in comparison to colposcopy guided biopsy.Materials & Methods: In this cross-sectional study, a total number of 200 women who were referred to the colposcopy clinic of Arash women’s hospital (Tehran, Iran) for cervical cancer screening, underwent VIA, VILI, and colposcopy guided biopsy during 2018-2019.Results: The calculated sensitivity and specificity of VIA and VILI in this population were (100% and 69.5%) and (100% and 60%), respectively, whereas the sensitivity and specificity of both VIA and VILI tests in combination were 100% and 77.2%. The positive and negative predictive values were 32.7% and 100%, respectively, when combined form of VIA and VILI was applied in this population.Conclusion: VIA and VILI alone or in combination could be used as screening tests to evaluate the presence of cervical cancer and in case of positive results, supplementary tests such as colposcopy guided biopsy could be performed for definite diagnosis.
Obstetrics and Gynecology
Mitra Modares Gilani; Azam Sadat Mousavi; Setareh Akhavan; Shahrzad Sheikhhasani
Volume 7, Issue 6 , September and October 2022, , Pages 530-535
Abstract
Background & Objective: Cervical cancer is one of the most common cancers in women. One of the most important indicators that deal with all aspects of the patients' health is the Health-related quality of life (QOL). In this study, the QOL of women with cervical cancer in Iran was investigated.Materials ...
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Background & Objective: Cervical cancer is one of the most common cancers in women. One of the most important indicators that deal with all aspects of the patients' health is the Health-related quality of life (QOL). In this study, the QOL of women with cervical cancer in Iran was investigated.Materials & Methods: The present cross-sectional study examined the QOL of 139 patients with cervical cancer referred to Imam Khomeini hospital, affiliated with the Tehran University of Medical Sciences. For this study, a specific questionnaire of QOL in patients with cervical cancer was used. To determine the predictors of cervical cancer patients, the QOL linear regression model was used.Results: Findings of this study showed that the total score of QOL of patients was 20.97±1.29. Moreover, in the regression model, a significant relationship was observed between the type of treatment and patients' QOL scores and those patients who had neoadjuvant therapy plus surgery (β=-17.45, P < /i>=0.02) and those who received brachytherapy (β=- 14.86 and P < /i>=0.09) had a significantly lower QOL score.Conclusion: Overall, the QOL of people with cervical cancer was moderate. Implementing educational programs for service providers and choosing the appropriate type of treatment according to the stage of the disease and the patient's age can help control this type of disease and its complications and improve the QOL of patients.
Obstetrics and Gynecology
Farah Farzaneh; Sama Mohammadi; Elnaz Ghaffari; Afsaneh Hosseini; Sarang Younesi; Mohammad Mahdi Taheri Amin; Payam Balvayeh; Fariba Navid Pour; Shahla Noori Ardebili
Volume 6, Issue 3 , June 2021, , Pages 122-127
Abstract
Background & Objective: Cervical cancer is the second most common cancer and the fourth leading cause of death in women. Among the risk factors for cervical cancer, human papillomavirus (HPV) is the most important one.Materials & Methods: In this cross-sectional and retrospective study conducted ...
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Background & Objective: Cervical cancer is the second most common cancer and the fourth leading cause of death in women. Among the risk factors for cervical cancer, human papillomavirus (HPV) is the most important one.Materials & Methods: In this cross-sectional and retrospective study conducted from 2016 to 2020, 261 women with cervical intra-epithelial neoplasia (CIN) grade two and three referred to one of the gynecological oncology clinics of Shahid Beheshti University of Medical Sciences, who were eligible to enter the study and were evaluated by the research unit of the relevant university after receiving an ethics code. During the study, patients whose cervical cancer was confirmed by colposcopic diagnostic method, HPV screening was performed by COBAS method and lesions were sampled to determine the type of HPV.Results: Evaluation of the frequency distribution of colposcopic results compared to HPV, indicated that HPV-16 is the most common type of HPV in high grade CIN lesions. After HPV-16, other types of HPV are next in terms of frequency indicating the importance of other types of HPV. HPV-18 was also observed in people with CIN.Conclusion: Performing a similar study with a larger number of samples at the national level is suggested. If the results of a larger study are consistent with this study, it would be for the best to highlight the role of other types of HPV in cervical cancer screening in women.
Gynecology Oncology
Maliheh Arab
Volume 6, Issue 1 , January 2021, , Pages 1-5
Abstract
In all cancers, the tendency for conservative treatment is on the rise. There are several options for fertility-sparing in cervical cancer including: a) Conization, b) Simple trachelectomy, c) Radical Trachelectomy including: Vaginal, Abdominal, Laparoscopic and Robotic. In conclusion, in young women ...
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In all cancers, the tendency for conservative treatment is on the rise. There are several options for fertility-sparing in cervical cancer including: a) Conization, b) Simple trachelectomy, c) Radical Trachelectomy including: Vaginal, Abdominal, Laparoscopic and Robotic. In conclusion, in young women with cervical cancer, fertility-sparing should be considered. In Conization is done in Stage 1A1 cases without LVSI. Conservative Surgery can be performed in stage 1B1 and 1A2 (Trachelectomy). MRI should be done in the early-stage cervical cancer before fertility- sparing.
Gynecology Oncology
Khadijeh Elmizadeh; Fatemeh Lalooha; Shahrzad Sheikh Hassani; Solmaz Chmanara
Volume 6, Issue 1 , January 2021, , Pages 16-21
Abstract
Background & Objective: This study aimed to examine the extent to which postcoital bleeding (PCB) can be a predictive factor for cervical cancer.Materials & Methods: In this observational study we selected and evaluated 280 females with PCB referred to Kowsar Hospital of Qazvin, Iran from 2017 ...
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Background & Objective: This study aimed to examine the extent to which postcoital bleeding (PCB) can be a predictive factor for cervical cancer.Materials & Methods: In this observational study we selected and evaluated 280 females with PCB referred to Kowsar Hospital of Qazvin, Iran from 2017 to 2019.Results: Among the 189 patients diagnosed as normal in their Pap smear results, one patient had cancer in her biopsy results. A closer look at the biopsy results of the patients showed 45 patients as normal, 64 patients with cervical infection, 31 patients with polyp cervix, 45 patients with cervical intraepithelial neoplasia 1 (CIN 1), and one patients with squamous cell carcinoma (SCC). Among 63 patients diagnosed with atypical squamous cells of undetermined significance (ASCUS), three showed CIN 2 and CIN 3 in their biopsies. Furthermore, out of 21 patients with low-grade squamous intraepithelial lesion (LSIL), three patients had CIN 2 and CIN 3, one patient had carcinoma, and one had SCC. In addition, all of the patients with high-grade squamous intraepithelial lesion (HGSIL) were diagnosed with CIN 2, CIN 3, and SCC.Conclusion: Because of the higher rate of cervical cancer in women with PCB and inconsistent screening programs in developing countries, it is essential to carefully consider the symptoms of PCB despite having a normal Pap smear.
Pathology
Zahra Shahi; Mohammad Amin Edalatmanesh; Babak kheirkhah
Volume 5, Issue 3 , November 2020, , Pages 110-114
Abstract
Background & Objective: Cervical cancer is the fourth most common cancer in women worldwide. HPV is a heterogeneous virus, and a persistent high-risk HPV infection contributes to cancer development. This study aims to determine the relative frequency of HPV genotypes in Kerman, Iran.Materials & ...
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Background & Objective: Cervical cancer is the fourth most common cancer in women worldwide. HPV is a heterogeneous virus, and a persistent high-risk HPV infection contributes to cancer development. This study aims to determine the relative frequency of HPV genotypes in Kerman, Iran.Materials & Methods: This cross-sectional study was conducted on 50 women with Pap smear samples, referring to a general laboratory in Kerman, Iran. Detecting two HPV genotypes was carried out using Multiplex Polymerase Chain Reaction (PCR) technique. The sociodemographic survey was conducted for each HPV-positive woman. Results: Out of 50 cervical cancer patients, 33 women (66%) were HPV 16, 18-positive. HPV 16 (38%) was the most rampant type, followed by HPV 18 (14%) and HPV 16, 18 (14%).Conclusion: Studying the prevalence of HPV genotypes and their respective risk factors can lead to efficient vaccine development against the virus in each geographical area. It can also be beneficial for illness management and high sensitivity diagnosis of cervical intraepithelial neoplasia.
Leili Bargi; Changiz Ahmadizadeh
Volume 4, Issue 2 , May and June 2019, , Pages 62-68
Abstract
Background & Objective: Cervical cancer is the second most prevalent cancer in women worldwide and is one of the leading causes of deaths in women with cancer in developing countries. The most well-known cause of this cancer is being infected with human papillomavirus (HPV). This study aimed ...
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Background & Objective: Cervical cancer is the second most prevalent cancer in women worldwide and is one of the leading causes of deaths in women with cancer in developing countries. The most well-known cause of this cancer is being infected with human papillomavirus (HPV). This study aimed at evaluating the concurrent methylation pattern of the human papillomavirus genome in studying the DAPK1 gene as a diagnostic biomarker in cervical cancer.
Materials & Methods: This study was approved by the Ethics Committee of the Islamic Azad University of Tabriz under the following ethical code, i.e., IR.IAU.TABRIZ.REC1398.001.This case-control study was conducted on 150 paraffin-embedded samples (75 marginal samples and 75 cervical cancer tissue samples) taken from women with cervical cancer. After extracting the total DNA, spectrophotometry and electrophoresis were performed on agarose gels to determine the quantity and quality of the extracted DNA. Changes in the DAPK1 gene methylation pattern were examined using High Resolution Melt Analysis Curve Method.
Results: The changes in theDAPK1 gene expression in the cervical tumor tissues increased compared to the marginal tissues, indicating a statistically significant difference (P < /em><0/0001).
Conclusion: The results of the current study showed that the DAPK1 gene can be introduced as a possible prognosis for cervical cancer diagnosis and treatment. However, more extensive studies with more samples are needed to be carried out.
Elham Shirali; Fariba Yarandi; Nadereh Behtash; Omid Hemmatian
Volume 3, Issue 2 , May and June 2018, , Pages 87-91
Abstract
Aims: Cervical cancer is one of the most common cancer in the female since 1990. Neoadjuvant chemotherapy (NACT) uses before surgery, especially in countries with limited radiotherapy facilities. The aim of the present review was to study the effect of NACT before radical surgery in comparison with other ...
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Aims: Cervical cancer is one of the most common cancer in the female since 1990. Neoadjuvant chemotherapy (NACT) uses before surgery, especially in countries with limited radiotherapy facilities. The aim of the present review was to study the effect of NACT before radical surgery in comparison with other treatments and various clinical outcomes.
Information and Methods: This study is a systematic review and includes previous publishes about cervical cancer and effect of NACT before radical surgery. Over 40 previous studies were reviewed, none of them was case report, at least 5 studies were randomized clinical trials and 6 of them were meta-analysis or systematic review.
Findings: NACT before surgery demonstrates advantages to reduce the rate of lymph node metastasis and parametrial infiltration, so improves progression-free survival in patients with pelvic lymph node invasion (Approximately 35% of stage IB2–IIB bulky). NACT also decreases tumor volume and minimizes the need for adjuvant radiotherapy, thus NACT under consideration of quality of life and cost-effectiveness should be recommended. NACT is really effective in decreasing incidence of pathological risk factors.
Conclusion: NACT response associated with the stage of diagnosis, tumor size and pathology of the specimen (Squamous tumor has a better response than a non-squamous tumor). NACT seems to be feasible in the management of stage IB bulky cervical cancer, NACT followed by surgery represent an alternative to primary chemoradiotherapy in young and sexually active patients.
Mojgan Karimi Zarchi; Soraya Teimoori
Volume 2, Issue 4 , November and December 2017, , Pages 1-2
