Gynecology Oncology
Fariba Behnamfar; Fatemeh Ahmadi Solush; Tajossadat Allameh
Volume 8, Issue 1 , January and February 2023, , Pages 11-16
Abstract
Background & Objective: Cervical Cancer (CC) is a common cancer which is associated with HPV-infection. The aim of this study is to investigate the risk factors which affects HPV-clearance.Materials & Methods: This study was carried out on women with high risk HPV infection. All the patients ...
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Background & Objective: Cervical Cancer (CC) is a common cancer which is associated with HPV-infection. The aim of this study is to investigate the risk factors which affects HPV-clearance.Materials & Methods: This study was carried out on women with high risk HPV infection. All the patients underwent pap smears and cervical biopsy. Demographic data, marital status, vaccination history and consumption of tobacco, alcohol, opium and oral contraceptive pills were asked through a questionnaire. Results: The results showed that in one year follow-up, 142 (67.1%) patients showed HPV clearance. The HPV clearance decreased by increasing age (P=0.028) or higher CIN grades (P=0.017). In case of parity, there was no significant difference in univariate analysis (P=0.147), but it was significant in multiple logistic regression analysis (95% CI: 0.413-0.941, OR=0624, P= 0.024).Conclusion: It seems that age and cervical histology at the start of HPV infection are the most important factors for HPV clearance.
Gynecology Oncology
Haleh Ayatollahi; Samira Jahangard; Siamak Naji; Zahra Yekta
Volume 7, Issue 3 , January and February 2022, , Pages 206-212
Abstract
Background and Objective: Cervical cancer is a common neoplasm in women, and the role of the HPV virus in the development of precancerous and cancerous cells has been established. There exist different strains of the HPV virus with varied functions. In the high-risk HPV strains, the p16 and ki67 proteins ...
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Background and Objective: Cervical cancer is a common neoplasm in women, and the role of the HPV virus in the development of precancerous and cancerous cells has been established. There exist different strains of the HPV virus with varied functions. In the high-risk HPV strains, the p16 and ki67 proteins play a crucial role in regulating the cell cycle leading to cell proliferation and progression. P16 and ki67 proteins are positive in almost all lesions and indicate a high degree of malignancy. This study aims to investigate the predictive effect of p16 and ki67 on the progression of low-grade intraepithelial lesions to high-grade malignancy.Methods: P16 and ki67 were measured on CIN1 lesions, and during the average two-year follow-up period, the outcome of positive cases was investigated. A total of 106 referred patients between the age of 15 to 75 years were examined from April 2015 to March 2019.Results: Among the patients with progression of CIN1 to CIN2 and other severe lesions, p16 was positive in 14 cases (60.9%), and a significant difference between groups with positive and negative markers in the progression or regression of lesions was noticed. Ki67 frequently occurs in CIN2 and other severe lesions.Conclusion: The use of p16 and ki67 as predictive markers is still under debate. In countries like the United States, these are not yet used separately for prediction but are being used in combination together. The authors of this study strongly recommend the conduction of further studies to assess the role of p16 in association with other markers and within a larger population so as to apply the functional role of p16 and ki67 in the clinical setting thereby effectively preventing it.
Obstetrics and Gynecology
Farah Farzaneh; Sama Mohammadi; Elnaz Ghaffari; Afsaneh Hosseini; Sarang Younesi; Mohammad Mahdi Taheri Amin; Payam Balvayeh; Fariba Navid Pour; Shahla Noori Ardebili
Volume 6, Issue 3 , June 2021, , Pages 122-127
Abstract
Background & Objective: Cervical cancer is the second most common cancer and the fourth leading cause of death in women. Among the risk factors for cervical cancer, human papillomavirus (HPV) is the most important one.Materials & Methods: In this cross-sectional and retrospective study conducted ...
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Background & Objective: Cervical cancer is the second most common cancer and the fourth leading cause of death in women. Among the risk factors for cervical cancer, human papillomavirus (HPV) is the most important one.Materials & Methods: In this cross-sectional and retrospective study conducted from 2016 to 2020, 261 women with cervical intra-epithelial neoplasia (CIN) grade two and three referred to one of the gynecological oncology clinics of Shahid Beheshti University of Medical Sciences, who were eligible to enter the study and were evaluated by the research unit of the relevant university after receiving an ethics code. During the study, patients whose cervical cancer was confirmed by colposcopic diagnostic method, HPV screening was performed by COBAS method and lesions were sampled to determine the type of HPV.Results: Evaluation of the frequency distribution of colposcopic results compared to HPV, indicated that HPV-16 is the most common type of HPV in high grade CIN lesions. After HPV-16, other types of HPV are next in terms of frequency indicating the importance of other types of HPV. HPV-18 was also observed in people with CIN.Conclusion: Performing a similar study with a larger number of samples at the national level is suggested. If the results of a larger study are consistent with this study, it would be for the best to highlight the role of other types of HPV in cervical cancer screening in women.
Pathology
Zahra Shahi; Mohammad Amin Edalatmanesh; Babak kheirkhah
Volume 5, Issue 3 , November 2020, , Pages 110-114
Abstract
Background & Objective: Cervical cancer is the fourth most common cancer in women worldwide. HPV is a heterogeneous virus, and a persistent high-risk HPV infection contributes to cancer development. This study aims to determine the relative frequency of HPV genotypes in Kerman, Iran.Materials & ...
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Background & Objective: Cervical cancer is the fourth most common cancer in women worldwide. HPV is a heterogeneous virus, and a persistent high-risk HPV infection contributes to cancer development. This study aims to determine the relative frequency of HPV genotypes in Kerman, Iran.Materials & Methods: This cross-sectional study was conducted on 50 women with Pap smear samples, referring to a general laboratory in Kerman, Iran. Detecting two HPV genotypes was carried out using Multiplex Polymerase Chain Reaction (PCR) technique. The sociodemographic survey was conducted for each HPV-positive woman. Results: Out of 50 cervical cancer patients, 33 women (66%) were HPV 16, 18-positive. HPV 16 (38%) was the most rampant type, followed by HPV 18 (14%) and HPV 16, 18 (14%).Conclusion: Studying the prevalence of HPV genotypes and their respective risk factors can lead to efficient vaccine development against the virus in each geographical area. It can also be beneficial for illness management and high sensitivity diagnosis of cervical intraepithelial neoplasia.
