Obstetrics and Gynecology
Leila Mousavi Seresht; Amir Reza Farhadi Dehkordi; Azar Danesh Shahraki; Pegah Hedaiat; Fedyeh Haghollahi
Volume 9, Issue 1 , January and February 2024, , Pages 102-105
Abstract
Invasive angiomyxoma as a mesenchymal tumor with a high recurrence rate has been reported mainly in reproductive age according to its association with the estrogenic level of plasma. Above that, it seems there is a need for further treatment despite complete resection of the tumor, to eliminate the hormonal ...
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Invasive angiomyxoma as a mesenchymal tumor with a high recurrence rate has been reported mainly in reproductive age according to its association with the estrogenic level of plasma. Above that, it seems there is a need for further treatment despite complete resection of the tumor, to eliminate the hormonal state. In the present study, we sought to introduce a rare case of invasive angiomyxoma in a post-menopausal but high-risk woman, discuss the relativity of risk factors in all hormonal-dependent gynecological malignancy, and intend to seek help from colleagues' opinions and experiences about treatment. It is clearly of great importance to emphasize the role of individualized medicine in such a rare case, in conclusion, there is not any debate on the role of surgical resection but the necessity of changing in lifestyle or adjuvant systemic or local therapy, and the needed duration is doubtful.
Obstetrics and Gynecology
Zinah Hammad; Ban J. Edan
Volume 8, Issue 2 , March and April 2023, , Pages 167-172
Abstract
Background & Objective: One of the worldwide healthcare problems is Diabetes mellitus (DM), and the prevalence of this disease increases steadily, particularly in pregnancy. The several metabolic disorders in the pregnancy were revealed by the placenta. The pathogenesis of diabetes mellitus ...
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Background & Objective: One of the worldwide healthcare problems is Diabetes mellitus (DM), and the prevalence of this disease increases steadily, particularly in pregnancy. The several metabolic disorders in the pregnancy were revealed by the placenta. The pathogenesis of diabetes mellitus is associated with hyperglycemia, insulin resistance, and oxidative stress, and it negatively impacts the mother-placenta-fetus system. This research aims to compare the amount of leptin expression, as well as its score and intensity, in the placentas of women with diabetes with those of healthy controls.Materials & Methods: In this work, we used a case-control methodology. Thirty women were diagnosed with diabetes and were placed in one group, while the other 40 served as a comparison. Primary monoclonal antibodies were used for the immunohistochemical analysis of leptin (Abcam, UK).Results: The patients group showed the greatest percentage (23%) of placental expression of leptin. The expression of leptin was high in around 53% of the patient population. The intensity of leptin expression was significantly higher in DM patient than control groups (P>0.05). About 77% of patients group had moderate intensity of leptin expression, while 37.5% of control group had no leptin expression.Conclusion: Diabetes mellitus was related with alterations in expressions of leptin as metabolic placental factor. Leptin may affect the pregnancy diverse disorders and pregnancy outcome.
Obstetrics and Gynecology
Nooshin Amjadi; Nasrin Mansori; Leili Rezaie Kahkha; Mojtaba Ashrafi; Saeedeh Chalaki; Khadije Rezaie Keikhaie
Volume 7, Issue 5 , July and August 2022, , Pages 445-451
Abstract
Background & Objective: Diabetes Mellitus refers to a group of specific metabolic diseases with a hyperglycemic phenotype. The present study compares pregnancy outcomes and nonstress tests (NST) in insulin-treated diabetic women with healthy pregnant women.Materials & Methods: In this cross-sectional ...
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Background & Objective: Diabetes Mellitus refers to a group of specific metabolic diseases with a hyperglycemic phenotype. The present study compares pregnancy outcomes and nonstress tests (NST) in insulin-treated diabetic women with healthy pregnant women.Materials & Methods: In this cross-sectional study, pregnancy outcomes and NST results were evaluated in 45 diabetic pregnant women who had received insulin therapy and 90 healthy pregnant women. The NST tracings of all women were applied and evaluated regarding reactive and non-reactive parameters. Data were analyzed using SPSS software version 20 and Fisher's exact test.Results: Our results demonstrated that NST was reactive in 75.6%and was non-reactive in 24.4% of diabetic mothers. There was a significant increase in macrosomia in diabetic mothers with non-reactive NST, while there was no statistical significance between NST results in the two groups. Conclusion: Pregnant women with diabetes are more prone to complications than healthy women. The main complication is the fetal size which leads to difficulties in delivery and increased incidence of cesarean section.