@article { author = {Pouryasin, Mohammad and Mousavi, Azam-Sadat and Pakravesh, Jalil and Zare Kamel, Delaram and Nooriardabili, Shahla and Khodadad, Shakiba and Aminimoghaddam, Soheila and Ghazimoghadam, Mehran and Farbod, Yasaman and Pouryasin, Ali}, title = {The Prevalence of HPV and non-HPV STIs Among Iranian Women and Assessment of the HPV/non-HPV STIs Co-infection on Cervical Cell Changes}, journal = {Journal of Obstetrics, Gynecology and Cancer Research}, volume = {7}, number = {5}, pages = {405-413}, year = {2022}, publisher = {Farname Inc. (Science-Based Research Institute; Professional Publisher of Scientific Journals)}, issn = {2645-3991}, eissn = {2476-5848}, doi = {10.30699/jogcr.7.5.405}, abstract = {Background & Objective: Persistent infection with some types of Human papillomavirus (HPV), which are high-risk genotypes, can lead the patients toward cervical cancer and, finally, death. Recent studies showed HPV co-infection with non-HPV sexually transmitted infections (non-HPV STIs) could increase the persistency rate of HPV infections. This study aimed to estimate the prevalence of STIs and assess the association of HPV/non-HPV STIs co-infection on cervical cell changes based on cytological findings.Materials & Methods: In this cross-sectional study, in addition to the routine cervical screening, including HPV testing and cytological assessment, non-HPV STI testing was performed on 1065 Iranian women. To assess the HPV and non-HPV STIs, commercial kits were used.Results: 964 (90.5%) women had normal cytology (NILM) results. The overall prevalence of HPV and non-HPV STIs were 39.1% and 68.5%, respectively. HPV-53 (6.5%), -16 (6.1%) and -31 (5.5%) were found as the most prevalent genotypes. Ureaplasma Parvum (UP) (42.7%), Group B Streptococcus (GBS) (23.7%), Candida Species (CS) (23.6%), Ureaplasma Urealyticum (UU) (9.6%), and Mycoplasma Hominis (MH) (7.1%) were found as the most prevalent non-HPV STIs. The co-infection of HPV with GBS played an important role in developing the cervical lesion (P < /i><0.05). Conclusion: In the present study, the STIs, including HPV, UP, GBS, CS, UU, and MH, were prevalent among the study participant, and it was found that the HPV/GBS co-infection played a significant role in the development of LSIL or worse cytological grades. To clarify this issue, further studies will be conducted.}, keywords = {Cervical Lesions,Co-infections,Group B Streptococcus (GBS),Human Papillomavirus (HPV),Sexually Transmitted Infection (STIs)}, url = {https://www.jogcr.com/article_697325.html}, eprint = {https://www.jogcr.com/article_697325_a6fa3f7c5fec7b8e1762598fd53e4e7b.pdf} }