@article { author = {El Sokkary, Hossam Hassan Aly Hassan}, title = {Comparative Study Between Superficial and Deep Myometrial Invasion in Endometrial Cancer Type 1 in Relation to Regional Lymph Nodes Metastasis}, journal = {Journal of Obstetrics, Gynecology and Cancer Research}, volume = {8}, number = {4}, pages = {357-365}, year = {2023}, publisher = {Farname Inc. (Science-Based Research Institute; Professional Publisher of Scientific Journals)}, issn = {2645-3991}, eissn = {2476-5848}, doi = {10.30699/jogcr.8.4.357}, abstract = {Background & Objective: The present study compares between superficial and deep myometrial invasion in type 1 endometrial cancer in relation to regional lymph nodes metastasis, so we can answer the question to do or not do lymphadenectomy, this life-threatening procedure in both superficial and deep myometrial invasion with type 1, clinically and radiologically stage 1 endometrial cancer.Materials & Methods: Patients were divided into 2 groups distributed as follows: group I includes 50 patients type 1 endometrial cancer with superficial myometrial invasion and group II includes 50 patients type 1 endometrial cancer with deep myometrial invasion. Total abdominal hysterectomy with bilateral salpingo-opherectomy with pelvic and lower para-aortic lymphadenectomy to all patients included in the study from both groups. Histopathological examinations were done to all the specimen from both groups to confirm diagnosis of type 1 endometrial cancer, depth of myometrial invasion, pathological grading and metastasis to the regional lymph nodes.Results: Considering regional lymph nodes metastasis in both groups, there is a statistical difference between group I and group II in relation to regional lymph nodes metastasis as group II (cases with deep myometrial invasion) are associated with more regional lymph nodes metastasis (P= 0.0001)).Conclusion: Deep myometrial invasion in type 1 endometrial cancer is associated with significant increase in regional lymph nodes metastases.}, keywords = {Endometroid adenocarcinoma,deep myometrial invasion,regional lymph nodes metastases,Lymphadenectomy}, url = {https://www.jogcr.com/article_697412.html}, eprint = {https://www.jogcr.com/article_697412_b3f4ebdc9a8d1ccb030f4340b10ba2ef.pdf} }