@article { author = {Javan, Mohammad Reza and Moghimian-Boroujeni, Bahareh and Ayatollahi, Hossein and Ayatollahi, Amirali and Amini, Nafise and Jafaei, Elham and Sheikhi, Maryam and Soltani, Narjes}, title = {The Role of Thrombophilia Factors Polymorphism and Cytogenetic Analysis in Recurrent Pregnancy Loss (RPL) in Northeastern Iran}, journal = {Journal of Obstetrics, Gynecology and Cancer Research}, volume = {8}, number = {4}, pages = {342-349}, year = {2023}, publisher = {Farname Inc. (Science-Based Research Institute; Professional Publisher of Scientific Journals)}, issn = {2645-3991}, eissn = {2476-5848}, doi = {10.30699/jogcr.8.4.342}, abstract = {Background & Objective: Recurrent pregnancy loss (RPL) is the occurrence of three or more miscarriages before the 20th week of pregnancy. Thrombophilia factors are one of the common causes of RPL.Materials & Methods: This retrospective study was performed on women with miscarriages. 620 patients’ documents with pregnancy loss were investigated. Based on the number of pregnancy loss, the women were divided into a control group with less than three miscarriages (212) and RPL group (180). Cytogenetics analysis and thrombophilia factors polymorphism tests were performed for all patients.Results: In the analysis, none of the studied polymorphisms (MTHFR 677 C⁄T /Factor V Leiden /Prothrombin G20210A/ ACE I/D/ PAI-1) showed a significant relationship between Control and RPL groups (P-value ˃ 0.05). Cytogenetic analysis showed 2 numerical and 9 structural abnormalities among both groups. Statistical analysis indicated a significant association between the number of abortions and age (P value= 0.005, r= 0.139). We even realized that there was a significant relationship between polymorphism number and recurrent number of miscarriages (P value= 0.018, r= 0.6).Conclusion: We showed that polymorphisms analysis for thrombophilia factors is a more precious test than cytogenetics analysis (study of the banded pattern of chromosomes during metaphase of the cell cycle). We even indicated that no association was found between thrombophilia polymorphisms in the control and RPL groups. This means that screening for Factor V Leiden, prothrombin G20210A, MTHFR C677T, ACE I/D, and PAI-1 and cytogenetic analysis in patients with a history of RPL is not recommended.}, keywords = {Thrombophilia factors,Cytogenetic,Recurrent Pregnancy Loss,Polymorphism,Chromosomal Abnormalities}, url = {https://www.jogcr.com/article_697413.html}, eprint = {https://www.jogcr.com/article_697413_6c1bd2c05dc994b8b0fe10ba8cf1d5c5.pdf} }