%0 Journal Article %T Six-Month Follow-Up After Mole Evacuation %J Journal of Obstetrics, Gynecology and Cancer Research %I Farname Inc. (Science-Based Research Institute; Professional Publisher of Scientific Journals) %Z 2645-3991 %A Farzaneh, Farah %A Vahedpour, Zahra %A Ashrafganjoei, Tahereh %A Rafizadeh, Mitra %A Ale Bouyeh, Hajar %A Hosseini, Maryamsadat %D 2022 %\ 11/14/2022 %V 1 %N 1 %P - %! Six-Month Follow-Up After Mole Evacuation %K GESTATIONAL TROPHOBLASTIC DISEASE %K Hydatidiform Moles %K HCG Beta %R 10.17795/jogcr-7331 %X Background and Objective: Most gestational trophoblastic neoplasias (GTN) develop following hydatidiform mole; but may occur after abortion, normal pregnancy or even ectopic pregnancy. Objectives: The aim of this study was to assess the importance of six-month follow-up of uncomplicated molar pregnancy after achieving undetectable β-human chorionic gonadotropin (β-hCG) levels. Methods: In this retrospective study, molar pregnancies with negative β-hCG were compared with those with positive β-hCG during a six-month follow-up. Results: A total of 279 women with molar pregnancy, treated at two referral university hospitals in Tehran were analyzed and 86 patients (31%) who had completed their follow-up period were included. Of the evaluated patients (n = 86), the pathology report indicated complete mole for 66 patients (77%) and partial mole for 20 patients (23%). All 86 patients had achieved at least one undetectable β-hCG level during their follow up, and none showed evidence of relapse. Conclusions: We found that in patients with uncomplicated molar pregnancy, relapse is unlikely after achieving undetectable serum β-hCG levels. Further investigations with larger sample sizes and preferably prospective design are needed to make a definite conclusion. %U https://www.jogcr.com/article_697080_5a86cdba0ea68810297dc5f58ba9d169.pdf