TY - JOUR ID - 697420 TI - Leptin Placental Expression in Pregnant Women with Diabetes: A Case Control Study JO - Journal of Obstetrics, Gynecology and Cancer Research JA - JOGCR LA - en SN - 2645-3991 AU - Hammad, Zinah AU - J. Edan, Ban AD - Collage of Medicine, University of Babylon, Babil, Iraq AD - Department of Physiology, Collage of Medicine, University of Babylon, Babil, Iraq Y1 - 2023 PY - 2023 VL - 8 IS - 2 SP - 167 EP - 172 KW - Leptin KW - Diabetes Mellitus KW - Pregnancy DO - 10.30699/jogcr.8.2.167 N2 - Background & Objective: One of the worldwide healthcare problems is Diabetes mellitus (DM), and the prevalence of this disease increases steadily, particularly in pregnancy. The several metabolic disorders in the pregnancy were revealed by the placenta. The pathogenesis of diabetes mellitus is associated with hyperglycemia, insulin resistance, and oxidative stress, and it negatively impacts the mother-placenta-fetus system. This research aims to compare the amount of leptin expression, as well as its score and intensity, in the placentas of women with diabetes with those of healthy controls.Materials & Methods: In this work, we used a case-control methodology. Thirty women were diagnosed with diabetes and were placed in one group, while the other 40 served as a comparison. Primary monoclonal antibodies were used for the immunohistochemical analysis of leptin (Abcam, UK).Results: The patients group showed the greatest percentage (23%) of placental expression of leptin. The expression of leptin was high in around 53% of the patient population. The intensity of leptin expression was significantly higher in DM patient than control groups (P>0.05). About 77% of patients group had moderate intensity of leptin expression, while 37.5% of control group had no leptin expression.Conclusion: Diabetes mellitus was related with alterations in expressions of leptin as metabolic placental factor. Leptin may affect the pregnancy diverse disorders and pregnancy outcome. UR - https://www.jogcr.com/article_697420.html L1 - https://www.jogcr.com/article_697420_10a5d06b7526a07963962a4990cefb05.pdf ER -