Azadeh Joulaee; Nasibeh Khaleghnejad-Tabari
Volume 2, Issue 4 , November and December 2017, , Pages 1-3
Abstract
The majority of cases are very young, less than 40 years old, which means they are out of the screening age range. For older pregnant women, screening is not done both due to possible radiation exposure of fetus and low accuracy of mammographyin pregnancy-induced highly dense breasts. Therefore, all ...
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The majority of cases are very young, less than 40 years old, which means they are out of the screening age range. For older pregnant women, screening is not done both due to possible radiation exposure of fetus and low accuracy of mammographyin pregnancy-induced highly dense breasts. Therefore, all the patients are symptomatic at presentation. Mass or ulcer in the breast, nipple or axilla; skin or nipple retraction, nipple scaling, unilateral uniduct spontaneous nipple discharge with any color, unilateral breast edema without or with redness (Peaud’orange) are the symptoms that bring the patient to her obstetrician. Thus, all pregnant women must be informed by their obstetricians about the possibility of breast cancer occurrence during pregnancy as well as all signs and symptoms of breast cancer. It should be noted that, stage by stage, the prognosis is the same as that of non-pregnant patients. Among the three breast imaging modalities, sonography is the first imaging procedure used for symptomatic pregnant women. It can safely be done during all trimesters of pregnancy. As always, sonography can differentiate solid tumors from cysts. Simple cysts are always benign, although they may present as large masses. Since there is no possibility for malignancy in these simple cysts, there would be no need for further follow-up because during the follow-up, their size and number can change or they may disappear spontaneously. These findings do not change our approach. In the case of large painful cysts, they can be aspirated using a needle either by surgeons or under the guide of sonography by a radiologist. On the other hand, if any solid mass is seen in the wall of a cyst, it is no longer a simple cyst and is considered as suspicious, thus classified as at least breast imaging reporting and data system (BIRADS) 4 needing immediate tissue diagnosis. Sonography, also, gives important information about solid tumors. By the evaluation of margins, vascularity, and elasticity, it can differentiate possibly benign tumor defined as BIRADS 3 from suspicious ones defined as BIRADS 4 or 5 that, again, need immediate tissue diagnosis. Well defined round or oval masses with fine margins without vascularity by Doppler evaluation and elastic, not rigid in elastography, are considered as possibly benign tumors or BIRADS 3 and can be followed by sonography instead of tissue diagnosis because the possibility of malignancy though not zero, is less than 2%. Sonography can, also, evaluate the lymp nodes in the breast and axilla; and diagnose the suspicious ones (thick cortex, round rather than kidney shape). If an LN is suspicious, tissue diagnosis is needed by needle biopsy which is usually done at the same time as the breast biopsy.
Mohammadmahdi Sabahi; Sara Amiahmadi; Rasool Haddadi
Volume 3, Issue 1 , March and April 2018, , Pages 1-7
Abstract
Aims: Various evidences have shown the effect of ovarian hormones on locomotor activities and catalepsy induced by a variety of stimuli. The aim of this study was to evaluate the effects of estrogen and progesterone on catalepsy and motor and balance impairment classified as haloperidol-induced extrapyramidal ...
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Aims: Various evidences have shown the effect of ovarian hormones on locomotor activities and catalepsy induced by a variety of stimuli. The aim of this study was to evaluate the effects of estrogen and progesterone on catalepsy and motor and balance impairment classified as haloperidol-induced extrapyramidal disorders.
Materials and Methods: The current experimental study was performed on 96 female Wistar rats (180-200g). These rats were randomly divided into 16 groups (n=6). Prior to administration of haloperidol, the rats were pretreated with flutamide (10mg/kg, i.p.), estrogen (1mg/kg 17 β-estradiol, s.c.), and/or progesterone (1mg/kg, i.p.) for 1 day or 7 consecutive days. The effects of estrogen and progesterone on haloperidol-induced catalepsy and motor impairment were assessed by a bar test and a rotarod performance test, respectively. Data were analyzed by SPSS 22 software using ANCOVA and Tukey test.
Findings: One to 7-day treatment with estrogen had a protective effect on haloperidol-induced extrapyramidal disorders such that it significantly improved catalepsy and motor impairment in the rats and restored and normalized their motor levels. However, the progesterone administration did not represent significant effects in improving extrapyramidal symptoms and a slight improvement was achieved. The co-administration of flutamide significantly reduced the protective effect of estrogen on catalepsy and motor balance impairment induced by haloperidol.
Conclusion: The deficiency of ovarian hormones increases catalepsy; however, this disorder is more likely to occur due to estrogen insufficiency. Hence, progesterone plays a little role in it. Moreover, the anti-cataleptic effect of ovarian hormones is exerted through affecting androgenic receptors.
Firoozeh Sadat Hashemi
Volume 4, Issue 1 , March and April 2019, , Pages 1-4
Abstract
Laparoscopy is a surgical procedure which has been used in gynecologic cancer since 1994. With technology progressing during years, there are so many kinds of minimally invasive surgeries in gynecologic malignancies. Regarding the importance of overall survival and progression of free survival in cancerous ...
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Laparoscopy is a surgical procedure which has been used in gynecologic cancer since 1994. With technology progressing during years, there are so many kinds of minimally invasive surgeries in gynecologic malignancies. Regarding the importance of overall survival and progression of free survival in cancerous patients, we should consider this type of surgery very wisely not to compromise patient's prognosis. Considering all the points above, a review was performed to study the role of laparoscopy in gynecologic oncology including endometrial and cervical cancer. It can be concluded that laparoscopy is not safe in a disease with high risk of tumor spread. Also a good prognosis of cancer patients should not be jeopardized by doing incomplete laparoscopic surgery.
Obstetrics and Gynecology
Maliheh Arab
Volume 5, Issue 1 , August 2020, , Pages 1-5
Abstract
Cancer in adolescent and young adults (AYA) includes people who are diagnosed with cancer at the age of 15–39. One of the main concerns and consequences of AYA cancer treatment in both sexes is infertility. Premature ovarian failure (POF) is common in multimodal chemotherapy regimens. There is ...
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Cancer in adolescent and young adults (AYA) includes people who are diagnosed with cancer at the age of 15–39. One of the main concerns and consequences of AYA cancer treatment in both sexes is infertility. Premature ovarian failure (POF) is common in multimodal chemotherapy regimens. There is a significant difference in the sensitivity of the ovary to drugs. In conclusion, in young cancer women, oophoropexy, infertility counseling, and embryo or oocyte cryopreservation should be considered. Medroxyprogesterone, oral contraceptive pill (OCP), or gonadotropin-releasing hormone (GnRH) should be prescribed in the risk of menorrhagia.
Gynecology Oncology
Maliheh Arab
Volume 6, Issue 1 , January 2021, , Pages 1-5
Abstract
In all cancers, the tendency for conservative treatment is on the rise. There are several options for fertility-sparing in cervical cancer including: a) Conization, b) Simple trachelectomy, c) Radical Trachelectomy including: Vaginal, Abdominal, Laparoscopic and Robotic. In conclusion, in young women ...
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In all cancers, the tendency for conservative treatment is on the rise. There are several options for fertility-sparing in cervical cancer including: a) Conization, b) Simple trachelectomy, c) Radical Trachelectomy including: Vaginal, Abdominal, Laparoscopic and Robotic. In conclusion, in young women with cervical cancer, fertility-sparing should be considered. In Conization is done in Stage 1A1 cases without LVSI. Conservative Surgery can be performed in stage 1B1 and 1A2 (Trachelectomy). MRI should be done in the early-stage cervical cancer before fertility- sparing.
Obstetrics and Gynecology
Amirreza Naseri; Sepideh Seyedi Sahebari; Mohammad-Salar Hosseini
Volume 7, Issue 1 , September and October 2021, , Pages 1-6
Abstract
The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a chief concern of the international community. As of May 2021, more than 150 million cases and 3.2 million deaths have been recorded. Considering the early struggle in treating COVID-19 ...
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The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a chief concern of the international community. As of May 2021, more than 150 million cases and 3.2 million deaths have been recorded. Considering the early struggle in treating COVID-19 patients, the researchers and clinicians have decided to try the previously available drugs according to their mechanisms of action. This article aims to review the potential drugs for COVID-19 patients during pregnancy and breastfeeding and their safety. PubMed and Scopus databases and Google Scholar engine were searched with the proper combination of the free keywords and MeSH Terms of COVID-19, SARS-CoV-2, Pregnancy, Breastfeeding, Treatment, Pharmacotherapy, Drug Therapy, and Drug Safety. All relevant clinical studies published until the end of 2020 were included in this review. Many antivirals, antibiotics, antiparasitics, and antipyretics have been proposed, but most of them are not registered for COVID-19 or have demonstrated little effect on the disease. Since there is still a long way to find an effective drug for the treatment of COVID-19, prevention is currently the most effective way. Also, prescribing drugs to these two groups of patients should be done according to the safety recommendations.
Obstetrics and Gynecology
Saeedeh Shahali; Farnaz Sahhaf Ebrahimi; Simin Taghavi; Elnaz Afsari
Volume 8, Issue 1 , November and December 2022, , Pages 1-10
Abstract
Background & Objective: Diabetes mellitus and gestational diabetes are complications that may be associated with preterm premature rupture of the membrane (i.e. PPROM) during pregnancy. We have investigate the impact of gestational and overt diabetes on PPROM through a statistical campaign. Materials ...
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Background & Objective: Diabetes mellitus and gestational diabetes are complications that may be associated with preterm premature rupture of the membrane (i.e. PPROM) during pregnancy. We have investigate the impact of gestational and overt diabetes on PPROM through a statistical campaign. Materials & Methods: This study was conducted in two parts: In the first part, the PPROM patients (211 cases) were classified into three groups, without diabetes (W/ODM=126 cases), gestational diabetes (GDM=69 cases consist of 44 cases under insulin therapy and 25 cases of diet controlled), and diabetes mellitus (ODM=16 cases). PPROM complications were studied and compared between these three groups. In the second part, GDM patients under insulin therapy or diet control were compared to W/ODM patients in terms of PPROM complications. Results: There were no significant statistical differences between the groups regarding pregnancy outcomes, except, for mean gestational age at rupture of membrane and delivery. For maternal outcomes, there were significant changes between groups in terms of labor duration, hospital stay after childbirth, and severe preeclampsia. Fetus and neonatal outcomes suggested that the newborn weight, neonatal hyperglycemia, Apgar score, revive need, infant death, and umbilical cord blood gas test results (except BE) were significantly different between the three groups. Results of the second part of the study, in terms of statistically significant differences between insulin therapy, diet control, and W/ODM are consistent with the first part, for all discussed factors. Conclusion: Results revealed that PPROM protocol management on PPROM cases who have gestational or overt diabetes is applicable and does not have any further risk.
Anesthesia
Shahram Sayadi; Shideh Ariana; Maral Hosseinzadeh; Arezou Ashari; Tannaz Yeganegi; Elham Memari; Ebtehaj Heshmatkhah; Dariush Abtahi
Volume 8, Issue 3 , May and June 2023, , Pages 1-1
Abstract
Background & Objective: Postpartum hemorrhage is the most common cause of maternal morbidity and mortality, which can occur unexpectedly without warning, and without any underlying causes. We hypothesized that administering fibrinogen concentrate to cesarean section patients before surgery would ...
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Background & Objective: Postpartum hemorrhage is the most common cause of maternal morbidity and mortality, which can occur unexpectedly without warning, and without any underlying causes. We hypothesized that administering fibrinogen concentrate to cesarean section patients before surgery would reduce perioperative blood loss.Materials & Methods: In this double-blind randomized controlled parallel group study, a single dosage of fibrinogen concentrate or a placebo was given to 260 cesarean section patients at random (by G*Power software, Heinrich-Heine-Universität Düsseldorf, Germany) in a university-affiliated general hospital between November 11, 2022, to January 8, 2023. Individuals in the fibrinogen group received a dose of one gram of fibrinogen concentrate and those in the placebo group received normal saline solution with the same volume in the placebo group. Total blood loss was the primary outcome of this study.Results: A total of 280 cases were screened and 260 were randomized. With a P-value of 0.001, the median (IQR) volume of bleeding in the fibrinogen group was 660 (341.25) mL, as opposed to 790 (475.00) mL in the placebo group. Comparatively, only 10 (7.7%) of the fibrinogen group and 26 (20%) of the placebo group required blood transfusions (P=0.006). No adverse event related to fibrinogen was reported. Conclusion: Empiric treatment with fibrinogen concentrate results in reduced blood loss.
Obstetrics and Gynecology
Golnaz Goodarzi; Sosan Rajabian; Maryam Ahmadian; Ateeh Kalateh
Volume 5, Issue 2 , October 2020, , Pages 31-38
Abstract
Background & Objective: Episiotomy is the most prevalent surgery in midwifery which can lead to infection or delay in wound healing like any other wound. Prophylactic antibiotics are currently prescribed after episiotomies in most Iranian centers. According to global efforts as well as WHO ...
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Background & Objective: Episiotomy is the most prevalent surgery in midwifery which can lead to infection or delay in wound healing like any other wound. Prophylactic antibiotics are currently prescribed after episiotomies in most Iranian centers. According to global efforts as well as WHO strategies to reduce antibacterial resistance, antibiotics are only prescribed when there is a definite medical indication and the benefit of taking them outweighs the harm. Therefore, this study aimed to compare the incidence of episiotomy site infection in two groups of primiparas with and without taking prophylactic antibiotics after normal vaginal delivery at Bent Al-Huda Hospital in Bojnourd.Materials & Methods: This double-blind randomized clinical trial was conducted on 140 primiparas (70 women in two groups, i.e., cephalexin and placebo capsules) at Bent Al-Huda Hospital in Bojnourd. After episiotomies, the patients took the prescribed medication every 6 hours for 7 days. The wound healing assessment was done by applying the REEDA scale (redness, edema, ecchymosis, discharge, and approximation of wound edges) seven days after the delivery. SPSS 18 were used to analyze the data. P-values below 0.05 were considered significant.Results: On the seventh day after the delivery, the two groups were different in terms of healing score based on the REEDA scale, and statistically significant differences were observed. The healing score was lower in the antibiotic group compared to the placebo group, indicating a better wound healing.Conclusion: The results showed the effectiveness of prophylactic antibiotics in treating episiotomy wounds.
Forough Mortazavi; Fateme Borzoee
Volume 4, Issue 2 , May and June 2019, , Pages 45-50
Abstract
Background & Objective: Fear of childbirth is an unpleasant and common condition that negatively affects pregnant women’s emotions and undermines the process of natural changes that occur during this period. This study was conducted to determine the relationship of fear of childbirth with the ...
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Background & Objective: Fear of childbirth is an unpleasant and common condition that negatively affects pregnant women’s emotions and undermines the process of natural changes that occur during this period. This study was conducted to determine the relationship of fear of childbirth with the severity of fatigue and the level of mental well-being in pregnant women.
Materials & Methods: This descriptive cross-sectional study followed by a correlation design was carried out on 525 pregnant women who referred to Sabzevar healthcare in 2017. Based on a cluster sampling method data collection was performed using demographic characteristics form, the Wijma Delivery Expectancy Questionnaire (WDEQ-A), the 5-item World Health Organization Well-Being Index (WHO-5), and the Multidimensional Assessment of Fatigue (MAF) scale. The data were analyzed by SPSS 16, using descriptive statistics, independent t-test, and Pearson correlation coefficient.
Results: 19% of the subjects scored above 85 and 6% of them scored higher than 100 on the WDE-Q. Also, 24.8% of these women scored less than 50 on the WHO-5. The studied women’s mean fatigue index was 20.3±12.7. Fear of childbirth had a positive correlation with fatigue (r=0.235) and a negative correlation with well-being (r=0.310) (P < /em><0.05).
Conclusion: Women experience various degrees of fear of childbirth during pregnancy. Providing mental support for pregnant women and using psychological techniques aimed at reducing their fear of childbirth during pregnancy are highly recommended.
Forough Javanmanesh; Maryam Kashanian; Sara Mirpang
Volume 3, Issue 2 , May and June 2018, , Pages 49-52
Abstract
Aims: The rate of induced abortion is growing worldwide. In this study, we aimed at comparing using misoprostol with or without Letrozole in abortion.
Materials and Methods: In this placebo-controlled trial, 46 women with a gestational age of fewer than 20 weeks, who were candidates of legal abortion, ...
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Aims: The rate of induced abortion is growing worldwide. In this study, we aimed at comparing using misoprostol with or without Letrozole in abortion.
Materials and Methods: In this placebo-controlled trial, 46 women with a gestational age of fewer than 20 weeks, who were candidates of legal abortion, were selected by simple randomization sampling method and randomly assigned into two groups. Drug group received 10mg daily Letrozole (4 tablets of 2.5mg) for 3 days prior to taking Misoprostol and the placebo group received daily placebo (4 tablets with the exact appearance of Letrozole) with the same instructions. After 3 days, Misoprostol was given to all the participants based on their gestational ages. The data were analyzed by SPSS 16 software, using independent sample t-test and Chi-square test.
Findings: 21 women (45.7%) had a successful complete abortion, and curettage was needed for 25 women (54.3%). Successful abortion rate was significantly higher in the group receiving Letrozole (78.3%) than the group receiving placebo (13.0%; p=0.0001). Mean induction-abortion interval was 22.61±7.721 hours in the drug group and 24.09±8.251 hours in the placebo group, which was not significantly different (p>0.05). There was no significant difference between the two groups in terms of vaginal bleeding and adverse effects.
Conclusion: Using 10mg daily Letrozole for 3 days followed by oral Misoprostol results in a significantly higher rate of complete abortion compared with placebo in women with a gestational age of less than 20 weeks.
Obstetrics and Gynecology
Mohamad Kazem Momeni; Omid Bameri; Mehrangiz Ghafari; Sima Saravani; Fereshteh Javadian
Volume 6, Issue 2 , March 2021, , Pages 50-56
Abstract
Today, opportunistic fungi, especially Candida albicans, are among the most common risk factors in patients with weakened immune systems. Fungal infections caused by Candida species and increasing number of azole-resistant strains are of great importance in immunocompromised patients. The toxicity of ...
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Today, opportunistic fungi, especially Candida albicans, are among the most common risk factors in patients with weakened immune systems. Fungal infections caused by Candida species and increasing number of azole-resistant strains are of great importance in immunocompromised patients. The toxicity of the drugs used, the development of resistance to these fungi, and the problems caused by drug interactions necessitate the use of more effective drugs with less toxicity. This study aimed to evaluate the antifungal activity of medicinal plant extracts on C. albicans. In this review study, Scopus, PubMed, MEDLINE, Google Scholar, SID, and Magiran databases were searched between 2000 and 2019 to identify related articles. The search keywords were “Candida albicans”, “Complementary”, “Herbal medicine” and their Persian equivalents. All in vivo and in vitro trials were included in the study. The reviewed studies showed the effectiveness of some compounds in inhibiting the growth of C. albicans. The results of the present research were in in-vitro conditions, but they need to be conducted in-vivo for human use.
Obstetrics and Gynecology
Geeta Bhardwaj; Alfisha Siddiqui; Lily Podder
Volume 7, Issue 2 , September and October 2021, , Pages 63-68
Abstract
Coronavirus disease 2019 (COVID-19) is a major public health concern, highly contagious in nature and/or causing high mortalities. This review paper reveals comprehensive interpretations of current COVID-19 reports and their impact on pregnancy in conjunction with antenatal visits, mental health, and ...
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Coronavirus disease 2019 (COVID-19) is a major public health concern, highly contagious in nature and/or causing high mortalities. This review paper reveals comprehensive interpretations of current COVID-19 reports and their impact on pregnancy in conjunction with antenatal visits, mental health, and mode of delivery. We further review recent guidelines of distinct leading organizations, which intend to serve as assistance in managing pregnant women with suspected or confirmed COVID-19. Pregnancy amid the COVID-19 pandemic necessitates marked importance deliberating high-risk status and vulnerability to severe COVID-19 related illnesses. The risk of vertical transmission is low; however, neonatal illness varies from asymptomatic to mildly symptomatic. Healthcare providers should consider proper guidance and obvious illustration of preventive strategies to limit the further spread of COVID-19. We also discuss the safety and efficacy of COVID-19 vaccines in pregnant women, besides benefiting both mother and baby.
Obstetrics and Gynecology
Zahra Rezaei; SeyedeMahsa Hadifar
Volume 5, Issue 3 , November 2020, , Pages 80-83
Abstract
Background and objective: Current study was conducted to determine the effects of Oxytocin drip on operative blood loss and fluid overload during hysteroscopy.Materials and Methods: In this double-blind randomized clinical trial, 54 women with abnormal uterine bleeding who were candidates for ...
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Background and objective: Current study was conducted to determine the effects of Oxytocin drip on operative blood loss and fluid overload during hysteroscopy.Materials and Methods: In this double-blind randomized clinical trial, 54 women with abnormal uterine bleeding who were candidates for hysteroscopy were consecutively enrolled and randomly assigned to receive either oxytocin or normal saline and the alterations in serum hemoglobin, sodium, albumin, and hematocrit were compared between two groups.Results: The results demonstrated that alterations in serum hemoglobin, sodium, albumin, and hematocrit did not significantly differ between the two groups (P < /em>>0.05).Conclusion: It seems using oxytocin drip during hysteroscopy in patients with intrauterine lesions would have no effect on operative blood loss and fluid overload.
Sedigheh Abdollahpour; Talat Khadivzadeh
Volume 4, Issue 3 , September and October 2019, , Pages 86-92
Abstract
Background & Objective: Traumatic childbirth, followed by postpartum stress, imposes many psychological consequences on women and their families. Therefore, this study was conducted to determine the prevalence of traumatic childbirth and postpartum post-traumatic stress in Iran using a systematic ...
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Background & Objective: Traumatic childbirth, followed by postpartum stress, imposes many psychological consequences on women and their families. Therefore, this study was conducted to determine the prevalence of traumatic childbirth and postpartum post-traumatic stress in Iran using a systematic review.
Materials & Methods: In this review, ISI, PubMed, Scopus, SID, Iranmedex, IranDoc, Magiran, and Google Scholar databases were searched to find relevant studies, by looking for the following keywords, i.e., prevalence, traumatic childbirth, post-traumatic stress, post-traumatic stress disorder, delivery or birth, Iran, and their English equivalents, in Persian and English-language journals published from 1981 to November 2018. Data were analyzed by the meta-analysis method using a random-effects model and the studies’ heterogeneity was calculated by the I2 index.
Results: Of a total of 1420 studies, 8 descriptive studies carried out from 2010 to 2017 were finally included after applying the inclusion and exclusion criteria. Among the 800 samples studied, the overall prevalence of traumatic childbirth was 51.3% and the overall prevalence of post-traumatic stress was 29.1% among the total of 2687 samples studied.
Conclusion: The prevalence of traumatic childbirth and post-traumatic stress is high in Iran; hence, it is necessary to carry out further studies to understand this important issue, so that more attention can be paid to mothers’ psychological problems to plan and make policies to maintain and improve their health in the postpartum period.
Hojjat Pourfathi; Haleh Farzin
Volume 3, Issue 3 , September and October 2018, , Pages 93-97
Abstract
Aims: Postpartum depression is a common event after delivery. Among some possible causes, pain is an important contributing factor which can play role in increasing psychiatric disease. The aim of the present study was to assess the effect of neuraxial analgesia methods on reducing incidence of postpartum ...
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Aims: Postpartum depression is a common event after delivery. Among some possible causes, pain is an important contributing factor which can play role in increasing psychiatric disease. The aim of the present study was to assess the effect of neuraxial analgesia methods on reducing incidence of postpartum depression.
Materials & Methods: 280 pregnant women (140 cases, 140 controls) without depression history who referred for vaginal delivery in the maternity ward of Taleghani teaching hospital, from February 2016 until February 2017 were participated in this randomized clinical trial. Samples were selected by random sampling method. Depression risk was assessed by Edinburgh Postnatal Depression Scale (EPDS) and the pain was measured by Visual Analogue Scale (VAS). Data were analyzed by SPSS 22 using Mann-whitney test and independent t-test for comparing of quantitative mean values. The association between qualitative variables was assessed by Chi square and exact Fisher tests.
Findings: Postpartum depression occurred in the painless delivery group and natural delivery group. There was statistically significant difference between them (p=0.04). It means that depression rate in painless delivery group was lower than natural delivery group. High Edinburg score was associated with high risk of depression.
Conclusion: Postpartum depression in women with painless delivery is lower comparison to women with natural delivery.
Reproductive Medicine
Samira Negahdari; Maede Nilechi; Mehdi Forouzesh; Seyed Farzad Hosseini; Azin Samimi; Mohsen Maleknia; Samira Valiyari; Marzieh Tavalaee
Volume 8, Issue 2 , January and February 2023, , Pages 95-104
Abstract
Surrogacy is an assisted reproductive technology in which the intended parents allocate the gestation and birth to another woman named the surrogate mother. From this view of surrogacy, although there is no genetic relationship between surrogate mother and fetus, this approach is faced with some ...
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Surrogacy is an assisted reproductive technology in which the intended parents allocate the gestation and birth to another woman named the surrogate mother. From this view of surrogacy, although there is no genetic relationship between surrogate mother and fetus, this approach is faced with some issues such as the epigenetic effect, which is the environmental influence on gene expression. Epigenetics plays a critical role in ovulation, spermatogenesis, and embryonic growth, development, and health. DNA methylation, histone modification, and non-coding RNAs activity are the major epigenetic mechanisms. In this mini-review, we focus on the possibility of epigenetic alterations during in vivo embryo culture and intrauterine life.
Obstetrics and Gynecology
Tahereh Ashrafganjoei; Atyeh Bahman; Somayyeh Noei Teymoordash; Soheila Aminimoghaddam; Abdolali Ebrahimi; Maryam Talayeh
Volume 6, Issue 3 , June 2021, , Pages 105-109
Abstract
Background & Objective: Endometrial carcinoma is the most common malignancy of the female genital tract, which most often affects postmenopausal women. The ovaries may be active when a patient has endometrial cancer, so removing an ovary can worsen a patient's quality of life. On the other hand, ...
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Background & Objective: Endometrial carcinoma is the most common malignancy of the female genital tract, which most often affects postmenopausal women. The ovaries may be active when a patient has endometrial cancer, so removing an ovary can worsen a patient's quality of life. On the other hand, a complete surgical staging in endometrial cancer includes oophorectomy since 1988. There has been some research to assess whether an oophorectomy should be performed and in which cases, ovaries can be preserved.Materials & Methods: Aim of this study was to evaluate the coexistence of ovarian involvement in endometrioid endometrial carcinoma. In this study, we evaluated 180 patients with endometrioid endometrial cancer patients who were surgically staged at Imam Hossein Hospital between 2004 and 2017.Results: Mean age of subjects of the study was 56.78 ±10.59. Forty-six of patients (25.6 %) were less than 50 years old and 74.4 % (134) were older than 50. Twenty out of 180 (11.1 %) of them had ovarian involvement (one of them had simultaneous ovarian tumor) and 11 (55%) of these cases were less than 50 years old. In 55 % (11) patients, the involved ovaries were less than 5 cm with grossly normal appearance, lymph nodes metastases were detected in 3 out of 20 (15 %) of them although their ovarian size were 4, 4.5 and 6.5 cm. In 10 (50 %) of them, deep myometrial invasion was detected.Conclusion: In endometrial cancer staging, ovarian preservation could be a challenging decision and a real controversy which needs more researches.
Shirin Haghighat
Volume 4, Issue 4 , September and October 2019, , Pages 131-134
Abstract
Epithelial ovarian cancer is one of the most common gynecological malignancies worldwide with an incidence of 225000 cases annually. For most patients, multimodality treatment including cytoreductive surgery and combination chemotherapy is an accepted standard of care. Despite the relatively favorable ...
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Epithelial ovarian cancer is one of the most common gynecological malignancies worldwide with an incidence of 225000 cases annually. For most patients, multimodality treatment including cytoreductive surgery and combination chemotherapy is an accepted standard of care. Despite the relatively favorable response to initial treatment, relapse free survival and overall survival are disappointing in patients with advanced ovarian cancer. Therefore, new treatment approaches have been proposed in recent years. The present review aims to describe the most relevant data published during the last four years on new approach to advanced ovarian cancer. Therefore, relevant studies were searched through Pubmed, Cochrane library and Scopus database published online until 2019. The most important changes studied in recent years have included the addition of new chemotherapy or targeted agent to first-line chemotherapy. Although combination of intravenous paclitaxel and carboplatin is currently accepted as the standard of care for treatment of advanced ovarian cancer, discussion around the intraperitoneal chemotherapy is still an important challenge. Additionally, much efforts have been dedicated to design an appropriate maintenance treatment as a goal of diminish the risk of recurrence. This review summarizes the results of most recent phase 3 trials surrounding optimal first-line chemotherapy, addition of a targeted agent including bevacizumab and maintenance treatment.
Reproductive Medicine
Khadijeh Saravani; Omid Bameri; Ideh Baradaran Kayal; Pantea Ramezan Nejad
Volume 5, Issue 4 , December 2020, , Pages 131-136
Abstract
Trichomonas vaginitis is the most common non-viral disease that is transmitted sexually. Although metronidazole is the most effective medication for this disease, it has some adverse effects. Herbal medicines have fewer side effects and are more popular among people. This study aimed to review the plants, ...
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Trichomonas vaginitis is the most common non-viral disease that is transmitted sexually. Although metronidazole is the most effective medication for this disease, it has some adverse effects. Herbal medicines have fewer side effects and are more popular among people. This study aimed to review the plants, which are effective against Trichomonas vaginalis and their therapeutic effects. For this purpose, the databases of Scopus, PubMed, Medline, Google Scholar, SID, and Magiran were searched for the articles published during 2000-2019 by keywords, such as Trichomonas vaginalis, complimentary, complementary therapies, herbal medicine, medicinal plants, and their Persian equivalents. All in vivo and in vitro trial studies were included in the present review. The data indicated that some compounds, including eucalyptus, case, and garlic were effective in inhibiting the growth of T. vaginalis.
Obstetrics and Gynecology
Nasibeh Roozbeh; Sepideh Hajian; Soodabeh Darvish; Zahra Kiani
Volume 7, Issue 3 , January and February 2022, , Pages 131-143
Abstract
Background & Objective: Given the significant role of low birth weight (LBW) in infant death and disability and relevant childhood diseases, the present systematic review was conducted to determine the factors affecting newborns’ birth weight in Iran.Materials & Methods: This study ...
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Background & Objective: Given the significant role of low birth weight (LBW) in infant death and disability and relevant childhood diseases, the present systematic review was conducted to determine the factors affecting newborns’ birth weight in Iran.Materials & Methods: This study systematically reviewed all the observational studies carried out in Iran between 1990 and 2021 (retrieval date: April 28, 2021) in four steps and through searches in Persian databases (including Magiran, SID, and IranDoc) and English databases (including Embase, Cochrane Library, Web of Sciences, Google Scholar, PubMed, and Scopus). All the relevant articles were searched by two researchers separately and collected using research keywords, Boolean operators, and a combination of relevant tags depending on the type of database. The quality of the articles was evaluated with 22-item Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) and Ottawa checklists, respectively.Results: Of the 251 articles collected, 31 met the study inclusion criteria. Variables such as the mother’s age (35%), body mass index (BMI) (25%), preterm childbirth, and diagnosis with a maternal chronic disease (25%) were found to be the most common causes of LBW in the reviewed studies, by order of prevalence.Conclusion: Based on the results of this review study and given that many of the known risk factors of LBW are preventable, the timely diagnosis, proper treatment, and follow-up of women at risk can prevent the birth of LBW infants.
Solmaz Fakhari; Hojjat Pourfathi; Haleh Farzin; Eisa Bilehjani
Volume 3, Issue 4 , November and December 2018, , Pages 137-142
Abstract
Breast cancer is a common type of cancer among female human populations. Approximately, one million new cases are diagnosed per year and it is expected that this amount will increase in the future. In recent years, the common standard surgical procedures for the treatment of breast invasive carcinoma ...
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Breast cancer is a common type of cancer among female human populations. Approximately, one million new cases are diagnosed per year and it is expected that this amount will increase in the future. In recent years, the common standard surgical procedures for the treatment of breast invasive carcinoma are breast-protective surgery and modified radical mastectomy. Residual tumor after surgery, stage T3–T4, metastases to 4 axillary lymph nodes or greater, and extracapsular axillary lymph node disease that is treated with adjuvant chemotherapy are indications of surgery. Post-mastectomy radiotherapy results in an increased disease-free condition and survival rate. With the improvement of survival rate, the procedure has been focused on quality of breast cancer survivors.
Reproductive Medicine
Shahrzad Zademodares; Masoumeh Abbaspour; Maryam Anbarluei; Nayereh Rahmati; Marzieh Fathi; Zahra Naeiji
Volume 6, Issue 4 , August 2021, , Pages 161-166
Abstract
Background & Objective: This retrospective study aims to evaluate the impact of pre-gestational maternal age and body weight on the outcome of IVF in women with polycystic ovary syndrome (PCOS). Materials & Methods: Medical records of 200 known cases of PCOS treated in a third level ...
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Background & Objective: This retrospective study aims to evaluate the impact of pre-gestational maternal age and body weight on the outcome of IVF in women with polycystic ovary syndrome (PCOS). Materials & Methods: Medical records of 200 known cases of PCOS treated in a third level referral center by the same therapeutic protocol were evaluated retrospectively. Demographic data, maternal body mass index (BMI), hormonal profile (LH, FSH, estradiol, and anti-mullerian), IVF cycle parameters and outcomes were documented. Patients were categorized into three groups based on their BMI (normal=18.5-24.9, overweight=25-30, obese≥30). IVF cycle parameters and outcomes were compared in the three groups. Effect of age was also evaluated by comparing the results in patients aged <35 and ≥35.Results: Mean age of patients was 32.5 (±5.2). A number of 72 patients had normal BMI, 85 patients were overweighed and 43 cases were obese. Baseline hormonal profile was similar in the three groups. Total dose of administered FSH was similar in the three groups. Number of retrieved oocytes was significantly higher in patients with BMI>30 but the number of mature oocytes and number of embryos were statistically lower in this group. Size of follicles showed no statistically significant difference in the three groups. Clinical pregnancy rate was significantly lower in patients with BMI>30 kg/m2 and age>35 years old.Conclusion: BMI>30 and age>35 years old have a statistically significant negative impact on IVF success rate.
Gynecology Oncology
Maryam Rahimi; Setareh Talebi Kakroodi; Mansoureh Tajvidi
Volume 7, Issue 4 , March and April 2022, , Pages 258-271
Abstract
Receptor tyrosine kinase (RTK) signaling is a crucial pathway in the development of many cancers. KIT, PI3K, and AKT are the major genes in this pathway. KIT RTK functions in cell signal transduction in various cell types, such as cancer cells. A central element of RTK signaling is phosphatidylinositol-4, ...
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Receptor tyrosine kinase (RTK) signaling is a crucial pathway in the development of many cancers. KIT, PI3K, and AKT are the major genes in this pathway. KIT RTK functions in cell signal transduction in various cell types, such as cancer cells. A central element of RTK signaling is phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit A (PIK3CA), involved in cell proliferation, survival, and growth. AKT is a serine/threonine-specific protein kinase that has an important role in several processes, such as apoptosis and cell proliferation. The importance of mutations and overexpression of KIT, PI3K, and AKT genes in breast cancer has been previously demonstrated. This review investigated the relationship between gene mutations and overexpression and clinicopathological variable of KIT, PI3K, and AKT in breast cancer. Finally, the role of inhibitor drugs of these genes in breast cancer treatment. These data were collected from PubMed and Google Scholar databases from 2000 to 2021. The expression of KIT, PI3K, and AKT genes in normal breast tissues has been observed. However, mutations and overexpression of these genes are associated with malignancies. The mutations in KIT, PI3K, and AKT genes are different from those found in other malignancies. Also, most of the drugs that inhibit the RTK signaling are being tested in clinical trials for the treatment of breast cancer. Monitoring and timely management of adverse effects are critical to minimize toxicities and optimize the efficacy of this targeted therapy. Therefore, further development of predictive biomarkers can better select patients who will benefit from RTK inhibitors.
Gynecology Oncology
Soheila Aminimoghaddam; Nima Azh; Somayyeh Noei Teymoordash; Firouzeh Ghaffari
Volume 7, Issue 5 , July and August 2022, , Pages 362-373
Abstract
Uterine cancer affects more than 1.28 million people worldwide; considering current world trends in obesity and aging, a +52.7% growth by 2040 is foreseen. Around 5% of endometrial cancer patients are less than 40 years old, meaning that conventional oncologic approaches would result in fertility loss; ...
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Uterine cancer affects more than 1.28 million people worldwide; considering current world trends in obesity and aging, a +52.7% growth by 2040 is foreseen. Around 5% of endometrial cancer patients are less than 40 years old, meaning that conventional oncologic approaches would result in fertility loss; thus, it is essential to consult patients regarding their fertility and family planning.Owing to developments of oncofertility, patients are now able to preserve their fertility and complete their childbearing, drafting from the standard of care in endometrial cancer. Strict criteria should be applied to make sure of selecting patients who benefit most from the fertility preservation approach. Furthermore, careful selection of patients increases the possibility of successful treatment.Most candidates for fertility preservation have risk factors in common with infertility, including polycystic ovarian syndrome, obesity, increasing of age and irregular menses; therefore, Advanced Reproductive Technology (ART) can improve their chances for pregnancy.Current applied knowledge towards the fertility preservation approach in patients with endometrial cancer is reviewed in this article.
