- Adibeh Mauwloudi 1
- Laleh Eslamian 2
- Vajiheh Marsousi 3
- Ashraf Jamal 4
- Maryam noorzadeh 5
- Mahsa Naemi 2
- Ali Reza Norouzi 6
- Nazila Mesbah 7
1 Resident of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, School of medicine, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Obstetrics and Gynecology, Perinatology Unit, Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Obstetrics and Gynecology, School of medicine, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Obstetrics and Gynecology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
5 Feto-Maternal Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
6 Assistant Professor of Pediatric Cardiology, Pediatric Respiratory Diseases Research Center (PRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7 Department of Obstetrics and Gynecology, Shariati Hospital, Tehran University of Medical Science, Tehran, Iran.
Epigenetic silencing of MLH1 in endometrial cancers is associated with larger tumor volume, increased rate of lymph node positivity, and reduced recurrence-free survival Background: The aim of this study was to determine which of the two drugs of ibuprofen, as a common non-steroidal anti-inflammatory drugs NSAID, and acetaminophen would have the least effect on postpartum hypertension in patients with preeclampsia.
Methods: Clinicodemographic data including age, gestational age at delivery, body mass index, parity, and route of delivery, were collected through interviews with patients and reviewing patient records. In this double-blind clinical trial, among 84 patients included in the study, 42 patients were randomly assigned into the acetaminophen (650 mg every 6 to 24 hours) and 42 patients into the ibuprofen (600 mg every 6 to 24 hours) group.
Results: The two groups were not significantly different in terms of mean age (p = 0.322), body mass index (p = 0.950), route of delivery (p = 0.657), parity (p = 0.818), and mean systolic (p = 0.530) and diastolic blood pressure (p = 0.691). Following the intervention, the duration of blood pressure control (p = 0.182), mean systolic blood pressure (p = 0.371), and mean diastolic blood pressure (p = 0.13) were not significantly different in the acetaminophen and ibuprofen groups. There was no significant difference between the two groups in terms of the number of patients and the dosage of opioids used.
Conclusion: The results revealed that in patients with preeclampsia, acetaminophen and ibuprofen to control postpartum pain have a similar impact on blood pressure.
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