Iranian Society of Gynecology Oncology


1 lecturer of obstetrics and gynecology-tanta university

2 ass.profeesor of obstetrics and gynecology-tanta university

3 assistant professor obstetrics and gynecology-tanta university


Objective: To evaluate the effect of weight gain in lean patients with polycystic ovary syndrome (PCOS) on ovulation and pregnancy rates.
Study design: A prospective observational study.
Patients: Lean patients with PCOS seeking fertility were invited to participate in the study. Weight gain was commenced by dietary modifications. Patients were classified later into respondent and non-respondent. All patients were stimulated with letrozole 2.5 mg twice daily for 5 days for 6 cycles. Ovulation and pregnancy rates were assessed.  
Results: From 84 patients who were enrolled in our study, 33 patients were allocated into non responder group and 28 patients were allocated in responder group  and It was found that despite there was statistical difference between both group as regard weight gain , weight after 6 months and  BMI after 6 months , there was no significant difference between both groups as regard  the ovulation rate , pregnancy rate and complications to ovulation induction (OHSS).
Conclusion: weight gain in lean PCOS patients - although non-significant- but it may improve the reproductive outcomes (ovulation rate and pregnancy rate) and the need of further study with larger number and longer duration of follow up for confirmation of this results.


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