Iranian Society of Gynecology Oncology

Document Type : Original Research Article


1 Department of Obstetrics and Gynecology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

2 Qazvin University of Medical Science

3 Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran


Background and Objective: The aim of labor induction is to stimulate uterine contractions before the spontaneous onset of labor, resulting in vaginal delivery. Misoprostol is used off-label for a variety of indications in the practice of obstetrics and gynecology. Regarding the importance and lack of similar research in Iran in Buccal, this research was done to compare the efficacy of Buccal, Vaginal, and Sublingual misoprostol for induction of labor in term pregnancy.
Materials & Methods: This study was conducted as a randomized clinical trial from 2017 to 2018. In this study, 300 women were randomly assigned to receive 50 µg Buccal misoprostol, 25 µg Vaginal, and 50 µg Sublingual in Kosar Hospital, Qazvin. The maternal and fetal complications, and Bishop score hour 1, and hour 6 were monitored in three groups and the findings were analyzed.
Results: The results showed that there were no differences between fetal complications (p>0.05) and maternal complications (p>0.05) among the three groups. Bishop score hour 1 (P = 0.146), Bishop Score hour 6 (P = 0.704), and total dose (P = 0.15) also were no differences among there groups. The results of the study showed that there was a significant difference between the three groups (P = 0.015) in achieving normal vaginal delivery within 24 hours, as Buccal, Sublingual and Vaginal groups were achieved respectively.  
Conclusion: This study found that there is no difference in terms of fetal complications and maternal complications in the three groups, but there was a significant difference in Oxytocin use and vaginal delivery within 24 h from the start of induction.