Adibeh Mauwloudi; Laleh Eslamian; Vajiheh Marsousi; Ashraf Jamal; Maryam noorzadeh; Mahsa Naemi; Ali Reza Norouzi; Nazila Mesbah
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Epigenetic silencing of MLH1 in endometrial cancers is associated with larger tumor volume, increased rate of lymph node positivity, and reduced recurrence-free survival Background: The aim of this study was to determine which of the two drugs of ibuprofen, as a common non-steroidal anti-inflammatory ...
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Epigenetic silencing of MLH1 in endometrial cancers is associated with larger tumor volume, increased rate of lymph node positivity, and reduced recurrence-free survival Background: The aim of this study was to determine which of the two drugs of ibuprofen, as a common non-steroidal anti-inflammatory drugs NSAID, and acetaminophen would have the least effect on postpartum hypertension in patients with preeclampsia.Methods: Clinicodemographic data including age, gestational age at delivery, body mass index, parity, and route of delivery, were collected through interviews with patients and reviewing patient records. In this double-blind clinical trial, among 84 patients included in the study, 42 patients were randomly assigned into the acetaminophen (650 mg every 6 to 24 hours) and 42 patients into the ibuprofen (600 mg every 6 to 24 hours) group. Results: The two groups were not significantly different in terms of mean age (p = 0.322), body mass index (p = 0.950), route of delivery (p = 0.657), parity (p = 0.818), and mean systolic (p = 0.530) and diastolic blood pressure (p = 0.691). Following the intervention, the duration of blood pressure control (p = 0.182), mean systolic blood pressure (p = 0.371), and mean diastolic blood pressure (p = 0.13) were not significantly different in the acetaminophen and ibuprofen groups. There was no significant difference between the two groups in terms of the number of patients and the dosage of opioids used.Conclusion: The results revealed that in patients with preeclampsia, acetaminophen and ibuprofen to control postpartum pain have a similar impact on blood pressure.
sedigheh Ghasemian Dizajmehr; Mahsa Mohammadi Irvanlou; Afshin mohammadi; farzaneh Rashidi fakari
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background: ovarian mature cystic teratomas (OMCTS) is one of the most common benign ovarian tumors. Most of MCTs can be diagnosed at ultrasonography (us). Due to heterogeneous composition and a variety of appearance, in some non-diagnostic imaging reports it is suggested that we evaluate some tumor ...
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Background: ovarian mature cystic teratomas (OMCTS) is one of the most common benign ovarian tumors. Most of MCTs can be diagnosed at ultrasonography (us). Due to heterogeneous composition and a variety of appearance, in some non-diagnostic imaging reports it is suggested that we evaluate some tumor markers (CA125 and CA19-9) to complement imaging modalities. According to previous investigation a single elevated CA 19-9 is in association of specific radio-pathologic features, such as size, torsion, bronchial glands, fat and teeth components. Here we are presenting three various cases of OMCT with different characteristics.Case Presentation: case 1: asymptomatic, non-diagnose US, single- elevated CA19-9, smaller than in 10 cm with bronchial glands and fat component. Case 2: symptomatic, non-diagnostic US , normal CA19-9, larger than 10 cm with torsion and necrosis. Case 3: symptomatic, diagnostic US, single- elevated CA19-9, smaller than 10 cm, full of hair and Sebaceous material. Computer tomography (CT), in all of our cases was diagnostic based on OMCT. Apologia of pathologic pathway of elevated CA19-9 in both case 1 and 3 was in agreement with the result of previous investigations. In case 2, despite of large size and torsion, CA 19-9 level was low.Conclusion: single- elevated CA 19-9 level in OMCTs could impact benign characteristics of this kind of tumor.
Maliheh Arab; Giti Noghabaei; Ghazaleh Fazli; Golnaz Fallah-Talouki; Hamed Tahmasebi; Masoomeh Raoufi; Behnaz Ghavami
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Introduction: Low-grade appendiceal mucinous neoplasm (LAMN) is a very rare condition, diagnosed in 0.2-0.7 % of appendectomies. Pathophysiology of the neoplasm involves accumulation of large volume of mucin in appendiceal lumen, resulting in its obstructive dilation. Most epithelial tumors affecting ...
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Introduction: Low-grade appendiceal mucinous neoplasm (LAMN) is a very rare condition, diagnosed in 0.2-0.7 % of appendectomies. Pathophysiology of the neoplasm involves accumulation of large volume of mucin in appendiceal lumen, resulting in its obstructive dilation. Most epithelial tumors affecting appendix are of the mucinous type and are manifested by mucin accumulation within an inflamed appendix with fibrotic and hyalinized wall.Case presentation: A 29-year-old female presented with history of chronic and intermittent episodes of abdominal pain and a palpable mass in the right lower abdominal quadrant. Sonography showed a 58 mm mass anterior to the uterus and adjacent to the ovary, probably a uterine myoma. Laparotomy revealed normal uterus, and ovaries with a translucent mass originating from appendix and fixed to cecum. Pathologic examination of the mass was reported as low grade appendiceal mucinous neoplasm.Conclusion: This is a rare case of appendiceal mucocele in a young female, mimicking pelvic mass, which was misinterpreted by sonography as gynecologic solid mass near uterus. Preoperative diagnosis of appendiceal mucocele is important due to the risk of concurrent GI and ovarian malignancy associated with the condition.Keywords: Mucocele; Appendix; pseudomyxoma peritonei; low-grade appendiceal mucinous neoplasm
Farnoush Farzi; Sodabeh Kazemi; Ziba Zahiri Sorouri; Samaneh Ghazanfar; Mahin Tayefeh Ashrafiyeh; Mandana Javanak; Mohammad Shahbazi
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Having body mass index more than 29 is described as obesity in pregnancy. Anesthesia management in these patients has always been challenging. A 41-year-old woman, at 37weeks’ gestation with the weight of 200kg and body mass index of 66/05 was admitted with complaint of pain to Al-Zahra Hospital ...
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Having body mass index more than 29 is described as obesity in pregnancy. Anesthesia management in these patients has always been challenging. A 41-year-old woman, at 37weeks’ gestation with the weight of 200kg and body mass index of 66/05 was admitted with complaint of pain to Al-Zahra Hospital in Rasht. She reported a history of two previous caesarean sections and high blood sugar and hypothyroidism which were under control by drugs. The Anesthesiology team decided to choose Continuous Spinal Anesthesia method for her. After performing anesthesia, cesarean delivery was done and a female neonate was born with Apgar score of 5-9. They were discharged from the hospital in good condition after two days. Based on the results of this study, CSA approach is a suitable method for anesthesia management in cesarean section of obese patients. Also it is necessary to recommend these patients to refer to anesthesia counseling clinics before giving birth.
Sara Masihi; Elahe Shirazi; Farideh Moramezi; Najmieh Saadati; Mojgan Barati
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
AbstractPurpose: This study aimed to compare CGH array and karyotype for prenatal diagnosis in high-risk individuals in the first trimester screening.Materials and Methods: The present cross-sectional descriptive prospective study was performed on high-risk mothers screened in the first trimester of ...
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AbstractPurpose: This study aimed to compare CGH array and karyotype for prenatal diagnosis in high-risk individuals in the first trimester screening.Materials and Methods: The present cross-sectional descriptive prospective study was performed on high-risk mothers screened in the first trimester of pregnancy. Individuals were allocated into two groups under karyotype and CGH array. Because this study is based on genetic testing data, it does not require a follow-up. Information on age, number of pregnancies, history of abortion, history of disease and screening results were collected and analyzed. Data analysis was done using SPSS Version 22 (IBM).Results: In total 247 cases were analyzed with 128 cases in the karyotype group and 119 cases in the CGH group. 116 samples (90.6%) in the karyotype group and 99 samples (83.2%) in the CGH group showed a normal karyotype. 4.2% (5 samples) and 7.9% (10 samples) of chromosomal abnormalities were trisomy in the CGH group and the karyotype group, respectively. CGH array analysis on chromosomal abnormalities identified copy number variation (CNV) in about 9.2% (11 samples) of cases. In terms of risk factors structural chromosomal, there was a statistically significant relationship in terms of history of disabled children in the family, maternal age, history of anomalies, screening of the first trimester of pregnancy, and increased NT (p<0.05).Conclusions: High-resolution arrays specifically prevented fetal malformations. Until now, normal prenatal chromosome analysis has been shown a relatively standard method but CGH may be helpful to specialists in diagnosing chromosomal abnormalities, especially in unknown chromosomal abnormalities.
Fereshteh Ameli; Maryam Entezarian; Noraidah Masir; Tan Geok Chin
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Introduction:The highest mortality rate in gynecologic cancers is attributed to ovarian origin. Expression of the estrogen and progesterone receptors (ER and PR); and Human epidermal growth factor receptor 2 (Her2/neu) in endometrial cancer and breast cancer were found to be associated with the response ...
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Introduction:The highest mortality rate in gynecologic cancers is attributed to ovarian origin. Expression of the estrogen and progesterone receptors (ER and PR); and Human epidermal growth factor receptor 2 (Her2/neu) in endometrial cancer and breast cancer were found to be associated with the response to treatment and prognosis. However, because of inconsistent results from previous studies, the data regarding ovarian cancer are still inconclusive.Materials and methods: Current retrospective cross-sectional study was performed on 234 tissue samples of different types of ovarian tumors (benign, borderline and malignant) from the archive of the University Kebangsaan Malaysia Medical Center during 10 years. Tissue microarrays were constructed on representative areas from formalin fixed paraffin embedded tissue blocks using ER, PR and HER2 immunohistochemical staining. Results: Prevalence of ER and PR overexpression was 36% and 35% in benign, 8% and 24% in borderline tumors with 51% and 46% in malignant tumors, respectively. ERα overexpression was more common among serous malignant ovarian tumors (49%) (p<0.001). PR positivity was more prevalent in serous benign tumors (p=0.02).There was no significant relationship between stage and the status of ERα (p=0.12) and PR (p=0.19). Her2/neu overexpression was only seen in borderline neoplasms (8%) and malignant mucinous tumors (4%). No association was found between Her2/neu overexpression and the level of tumor differentiation, tumor stage, size, and patient’s age.Conclusion: The observed ERα positivity in serous carcinoma and Her2/neu overexpression in malignant mucinous tumor, could be considered as a clue for choosing therapeutic agents. The role of anti-HER2 therapy in clear cell carcinoma is still debated and needs more investigations.
Fariba Almassinokiani; Mahzad Alimian; Parinaz Hamednasimi
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background: Hysterectomy is the most common gynecological surgery. Every year, a large number of women around the world undergo this type of surgery for various reasons. Regardless of the type of surgery, bleeding during surgery and after surgery is the most common. Tranexamic acid is a cheap, available ...
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Background: Hysterectomy is the most common gynecological surgery. Every year, a large number of women around the world undergo this type of surgery for various reasons. Regardless of the type of surgery, bleeding during surgery and after surgery is the most common. Tranexamic acid is a cheap, available and low-complication drug that has been considered in recent years to control bleeding. The present study investigated the effectiveness of Tranexamic acid on the bleeding during laparotomy hysterectomy in women aged 35 to 55 years.Methods and materials: This study was a randomized, double-blind clinical trial performed on 80 patients undergoing laparotomy hysterectomy. Using a random number table, patients were divided into two groups A (receiving Transid) and the other group receiving drug B (not receiving Transid), both of which received 100 ml of normal saline prepared to reduce bias in the prepared syringe.Results: Mean age of the patients was 46.24 ± 5.21 years. Based on the results of mean hemoglobin before surgery, the rate of infection, infusion and induction in the control and intervention groups were not statistically different (P> 0.05). Also, the mean of hemoglobin variables before and after, hemorrhage estimated by the surgeon and hemorrhage estimated according to Hernandez formula were not statistically different in the two groups (P> 0.05).Conclusion: Tranexamic acid administration has no effect on the amount of bleeding during hysterectomy laparotomy.
Hamideh Parsapour; Aida Alizamir; Shahedeh Khansary; Nasrin Jiryaei; Fatemeh Navabi
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background: Gonorrhea is an infection caused by Neisseria gonorrhoeae that is mainly transmitted through sexual intercourse. This study was performed to evaluate the frequency of Neisseria gonorrhoeae and antibiotic resistance pattern to this infection in women referred to Fatemieh Gynecology Clinic ...
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Background: Gonorrhea is an infection caused by Neisseria gonorrhoeae that is mainly transmitted through sexual intercourse. This study was performed to evaluate the frequency of Neisseria gonorrhoeae and antibiotic resistance pattern to this infection in women referred to Fatemieh Gynecology Clinic in Hamadan.Methods: In this cross-sectional study using the convenience sampling method, 348 women referred to the gynecology clinic of Fatemieh Hospital in Hamadan in 2020 with complaints of vaginal discharge or vague pelvic pain were investigated. Patients were examined by a gynecologist, and if were eligible, a sample of endocervix is prepared and sent to the laboratory. Samples were cultured in a Thayer –Martin agar, then were examined by a cytopathologist for Neisseriagnore and Chlamydia and the results were recorded in a researcher-made checklist. Data were analyzed using SPSS software version 16.Results: The mean age of women was 34.93 ±7.57 years, and 72.7% lived in urban areas. Common complaints of women included pelvic inflammatory disease (56.9%), cervical discharge (73.6%), dysuria (25.6%), and dyspareunia (22.7%). None of the women had multiple sexual partners, hepatitis B or hepatitis C. one case (0.29%) of Neisseria gonorrhoeae was observed that be resistant to the antibiotics penicillin tetracycline, minocycline, and cefazolin and was sensitive to the antibiotics chloramphenicol, rifampin, nitrosamine, cefoxitin, and ceftazidime.Conclusion: It seems that in women with cervicitis at reproductive age, without a history of high-risk sexual behaviors, Neisseria gonorrhoeae infection is less common and is not a significant problem.
fereshteh fakour; Roya KaboodMehri; Amirhossein hajizadeh Fallah; Maryam Dourandeesh; Fatemeh Gholamalipour; Seyedeh Maryam Attari; forozan Milani; zahra pourhabibi
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background and objective: Most pain relief methods are associated with some side effects and limitations. Magnesium sulfate, due to its osmotic properties and absorption of cervical water (moisture) can shorten labor duration and decrease labor pain via improving effacement and cervical edema. ...
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Background and objective: Most pain relief methods are associated with some side effects and limitations. Magnesium sulfate, due to its osmotic properties and absorption of cervical water (moisture) can shorten labor duration and decrease labor pain via improving effacement and cervical edema. The aim of our study was to evaluate the effect of intravaginal magnesium sulfate on pain severity and duration of the first and second stages of labor. METHODS: In this double-blind randomized clinical trial study, 70 nulliparous women were allocated into two groups after the beginning of the active phase of labor. In the group 1, 10 ccs of magnesium sulfate 50% was poured on the whole cervix during the vaginal examination. In the group 2, a placebo (sterile water) in the similar way and amount was used. Then the two groups were compared in variables of demographic, obstetrics, clinical, pain severity, and duration of the first and second stages of labor, maternal and neonatal outcomes.RESULTS: In different dilatations, pain severity in the group 1 was significantly lower (p=0.0001). The duration of the first and second stages of labor was shorter in the group 1 (p=0.0001). The two groups were similar in neonatal outcomes, drug side effects, and treatment satisfaction(p>0.05).CONCLUSION: Intravaginal magnesium sulfate improves the condition of the cervix, reduces the duration and the severity of labor pain, and has no medical or neonatal side effects.
Maliheh Arab; Nafiseh poorzad; Giti Noghabaei; Ghazaleh Fazli; Behnaz Ghavami; Tayebeh jahed Bozorgan
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Cancer survivorship care tries to discover improved healthy lifestyles for cancer patients, rather than just managing the complications; thus, it seems necessary to identify the aspects associated with general well-being in order to design proper care, and confront difficulties that cancer survivors ...
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Cancer survivorship care tries to discover improved healthy lifestyles for cancer patients, rather than just managing the complications; thus, it seems necessary to identify the aspects associated with general well-being in order to design proper care, and confront difficulties that cancer survivors encounter such as anxiety, depression, cognitive dysfunction, weakness and fatigue, pain, sexual dysfunction, and sleep disorders (1-4). Cancer survivorship assessment from the National Comprehensive Cancer Network clinical practice guidelines in oncology (NCCN guidelines. survivorship, version 2.2020) is one of the most common and valid tools for measuring the quality of life in cancer survivors (3-6).Gynecological cancer survivors have been growing, as a result of advancements in national cancer screening strategies, resulting in early-stage diagnosis, and cancer treatments developments; thus, general mortality to incidence ratios have been declined from 2000 to 2015, in Iran. However, lack of a valid documented assessment tool to measure their requirements for supportive care is detected (7). It seems indispensable to provide a translated adapted version of NCCN survivorship questionnaire, to offer the Iranian cancer care providers have the prospect in comparison and approaches in a transcultural framework. The present study proposed to represent a renovated double back translation to revise and culturally adapt the original English version of cancer survivors’ assessment questionnaire into the Persian version in order to achieve a reliable tool that meets the clinical research needs of Iranian researchers at the desired level. The aim was to develop a comprehensive scale that comprises all features of gynecologic cancer survivors` requirements in Iranian population, equivalent to NCCN guideline hypothetical concept.
Somayeh Khanjani; Shamin Ghobadi; farahnaz mardanian; Leila Mousavi seresht
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Introduction: caesarian scar pregnancy became a worrisome obstetric problem as a side effect of rising number of caesarian sections these days. Furthermore, from the challenge of diagnosis in case of low suspicious in the initial prenatal sonographic screening, there is remaining debate of the standard ...
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Introduction: caesarian scar pregnancy became a worrisome obstetric problem as a side effect of rising number of caesarian sections these days. Furthermore, from the challenge of diagnosis in case of low suspicious in the initial prenatal sonographic screening, there is remaining debate of the standard of management. According to rare reported cases, the most acceptable recommendation still is termination of pregnancy to decrease the chance of further maternal dreadful complication. Material and method: here we assumed to explain a rare case of scar-pregnancy with fortunate outcome.Result: A case of twin pregnancy had been terminated in gestational age of 34 weeks in a tertiary care center with history of first trimesters diagnosis of caesarian scar pregnancy, who had decided to continue pregnancy under close follow-up.Conclusion: Since pregnancy at the site of a previous cesarean section is very rare, but due to the complications of this type of pregnancy, choosing a suitable clinical approach for these patients is desirable.This type of pregnancy can increase the value of antenatal care if it can be continued until the fetus is viable and its complications, including placenta accreta and bleeding, are managed.
Behjat Khorsandi
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background and Objective: Understanding the reproductive and sexual needs of pregnant women seems to be crucial in increasing the effectiveness of services and addressing their needs and expectations. Therefore, the aim of this study was to explain the needs and concerns of reproductive and sexual health ...
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Background and Objective: Understanding the reproductive and sexual needs of pregnant women seems to be crucial in increasing the effectiveness of services and addressing their needs and expectations. Therefore, the aim of this study was to explain the needs and concerns of reproductive and sexual health of pregnant women during the COVID-19 pandemic.Method: This is a qualitative study with a content analysis approach. In this probe, 16 interviews were accomplished with 15 pregnant women who had referred to public and private pregnancy care centers. Data analysis was performed predicated on the content analysis approach using MAXQDA software version 12. Results: Based on 16 interviews conducted with pregnant women during COVID-19 pandemic, 19 women were found to be suffering from mental disorders, fears, Disrupting prenatal care and sexual problems.Conclusion: According to the results of this study and other studies in the area of reproductive and sexual health, due to its importance in the quality of individual and married life, it should be considered in health planning activities and scores of studies and interventions in these areas are thus suggested
Ghodratolah Maddah; Mohammad Ali Mohammadzadeh Rezae; Zohreh Yousefi Zohreh Yousefi; Helena Azimi; leila mousavi seresht
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Pelvic exenteration and other type of super-radical procedure is the standard of care in the management of patients with recurrent or persistent cervical cancer. But, since the extent of surgery and possible morbidities are considered as an important challenge in low-resource countries, the present study ...
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Pelvic exenteration and other type of super-radical procedure is the standard of care in the management of patients with recurrent or persistent cervical cancer. But, since the extent of surgery and possible morbidities are considered as an important challenge in low-resource countries, the present study tries to report the successful outcome of radical surgery in detailed in 7 cases in a low-economic setting. The most valuable point of success is the importance of the multidisciplinary decision, the necessity of experience in this field, psychological consultations with patients, and being prepared for the potential surgical complications. What we had noticed was the excellent survival prognosis even in curative intent. It is highly recommended, considering the psychological effect of such an extensive surgery and quality of life in these patients with advanced disease and loss of hope.
Nahid Shahbazian; Mahvash Zargar; Mojgan Barati; Najmieh Saadati; Elham direkvand
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background and Objective: Thyroid-related adverse pregnancy outcomes can be analyzed by Anti-thyroid peroxidase antibody (TPO-Ab). However, whether women with anti-thyroid peroxidase antibody (TPOAb) positivity have a higher risk of poor pregnancy outcomes is debatable. The aim of present study ...
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Background and Objective: Thyroid-related adverse pregnancy outcomes can be analyzed by Anti-thyroid peroxidase antibody (TPO-Ab). However, whether women with anti-thyroid peroxidase antibody (TPOAb) positivity have a higher risk of poor pregnancy outcomes is debatable. The aim of present study was to comparison of pregnancy outcomes in pregnant women with positive and negative TPO-Ab. Methods: This cross-sectional study was conducted on pregnant women with positive anti-TPO Ab (n= 108) and negative anti-TPO Ab (n=340) referring to Imam Khomeini Hospital and Ahvaz clinics from January 2020 to December 2020. The pregnancy outcomes, including gestational diabetes mellitus (GDM), preeclampsia, miscarriage, preterm birth, placental abruption, IUFD, IUGR, and TSH level, were compared between the two groups by SPSS software using student t-test and Chi-square test.Results: The mean TSH level was significantly different in women with negative TPO-Ab than those with positive TPO-Ab (Mean (SD): 2.25(1.47) vs. 4.82(9.38), P<0.0001). In addition, 81 (75.00%) women in the positive anti-TPO group and 104 (30.58%) in the negative anti-TPO group had high TSH (P<0.001). The frequency of GDM in positive anti-TPO Ab pregnant women was significantly higher than that in the negative anti-TPO Ab group (46.29% vs. 34.11%, P=0.029). The results also indicated an enhancement in the rate of miscarriage (15.74% vs. 4.11%, P<0.001) and preterm parturition (13.88% vs. 3.52%, P<0.001) in positive anti-TPO Ab women. Conclusions: Presence of positive anti-TPO Ab was significantly associated with preterm delivery, abortion and GDM in pregnancy. Treatment with Levothyroxine can reduce the risk of adverse pregnancy outcomes in women who are positive for TPOAb. .
Hamideh Pakniat; Khadijeh Elmizadeh; Fatemeh Lalouha; Hojjat Momenzade; kimia mahloojian
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background & Objective: The importance of Pap smear in cervical cancer screening is clear. However, yet no organized program has been developed in Iran to screen cervical cancer. Due to the obvious difference in prevalence of cervical cancer in Iran compared to global statistics, it is necessary ...
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Background & Objective: The importance of Pap smear in cervical cancer screening is clear. However, yet no organized program has been developed in Iran to screen cervical cancer. Due to the obvious difference in prevalence of cervical cancer in Iran compared to global statistics, it is necessary to further investigate this issue. As pop smear is the most important factor to decrease the mortality and morbidity of cervical cancer in developed countries, it is important to study the results of abnormal Pap smears and the quality of the report in our region. Materials & Methods: This study was designed retrospectively with reference to the results of Pap smears performed during 3 years from 2016 in the Kosar hospital. The method of collecting samples was census. The results of Pap smears were extracted from the Hospital and 15208 pap smear results were analyzed.Results: From the 15208 women, 15150 had normal cytology results (99.62%) and 58 women had abnormal cytology (0.38%). The frequency of abnormal cytology was 0.246% (n=37) for atypical squamous cell of undetermined significance (ASCUS), 0.08% (n=12) for low-grade squamous intraepithelial lesion (LSIL), 0.006% (n=1)for ASC cannot exclude high-grade intraepithelial lesion (ASC-H), 0.046% (n=7) for high-grade squamous intraepithelial lesion(HSIL), 0.006 (n=1)for atypical glandular cells (AGC), and 0% (n=0) for invasive cancer. No SCC was found in this study. Conclusion: The prevalence of all abnormal results was much lower than other studies; However, in terms of prevalence of abnormalities, the ranking was similar to other studies.In order to obtain more accurate results, it is recommended to study other epidemiological regions.
Mahrokh Abouali Gale Dari; Mona Keivan; Farideh Moramezi; Najmieh Saadati; Roshan Nikbakht; Maryam Farzaneh
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Polycystic ovary syndrome (PCOS) is a hormonal disorder that affecting women of reproductive age. Several genetic and environmental factors are contributed to the progression of PCOS. Experimental discoveries have begun to evaluate the mechanisms involved in PCOS. There is a mechanistic link between ...
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Polycystic ovary syndrome (PCOS) is a hormonal disorder that affecting women of reproductive age. Several genetic and environmental factors are contributed to the progression of PCOS. Experimental discoveries have begun to evaluate the mechanisms involved in PCOS. There is a mechanistic link between long non-coding RNAs (lncRNAs) and the pathogenesis of PCOS. LncRNAs are a class of transcripts that mediate the process of gene expressions at the level of transcription and post-transcription. It has been found that lncRNA MALAT-1 presents a vital role in regulating PCOS. MALAT-1 as a competing endogenous RNA (ceRNA) can suppress microRNAs (miRNAs) and decrease granulosa cell proliferation, apoptosis, and pathogenesis. In the present article, we summarize the functions of the lncRNA MALAT-1/miRNA axes in PCOS.
Poorya Davoodi; Delaram J. Ghadimi; Malihe Rezaei; Mohammad Amin Khazei Tabari; Aryan Shirani; Behnaz Nouri; Noosha Samieefar; Meisam Akhlaghdoust
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
AbstractObjectives: Endometriosis, a common disease of the female reproductive system, could affect many aspects of the life of women. Along with many other diseases, COVID-19 has affected the diagnostic or treatment approaches towards endometriosis. This systematic review aims to investigate COVID-19 ...
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AbstractObjectives: Endometriosis, a common disease of the female reproductive system, could affect many aspects of the life of women. Along with many other diseases, COVID-19 has affected the diagnostic or treatment approaches towards endometriosis. This systematic review aims to investigate COVID-19 in endometriosis patients in terms of prognosis, diagnosis and treatment, and quality of life during the pandemic.Methods: Relevant studies were identified through searching for endometriosis and COVID-19 in different databases, including PubMed, Medline, Scopus, and Web of Science, on 17 January 2022. Peer-reviewed published articles evaluating COVID-19 and endometriosis written in English were included.Results: Out of 115 articles, 9 manuscripts met our criteria. Endometriosis does not intensify the risk of COVID-19 infection. However, COVID-19 has changed the health care of endometriosis patients. Conclusions: COVID-19 has affected endometriosis patients’ life from many aspects, including their job, lifestyle, and health care. Further studies are recommended to evaluate how the pandemic has affected endometriosis patients.
Soheila Aminimoghaddam; Zahra Vahedpoor; Shabnam Bozorgzadeh
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Abstract:Hereditary non polyposis colorectal cancer (HNPCC) also known as lynch syndrome (LS), is an autosomal dominant cancer syndrome. Besides colorectal cancers it predisposes patients to extra-colonic cancers. The screening may be effective for early detection of colorectal cancers, whereas the efficacy ...
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Abstract:Hereditary non polyposis colorectal cancer (HNPCC) also known as lynch syndrome (LS), is an autosomal dominant cancer syndrome. Besides colorectal cancers it predisposes patients to extra-colonic cancers. The screening may be effective for early detection of colorectal cancers, whereas the efficacy of surveillance for other organ tumors has not yet been established. Despite several extra-colonic cancer have been reported on LS, we found a new face of it.A 43-year-old G2L2 patient with chief complaint of abnormal uterine bleeding (AUB) referred to a gynecologist. A biopsy of her endometrium showed clear cell carcinoma, and the necessary work-ups have been done. But the patient's family history demonstrated HNPCC based on the Amsterdam 2 criteria. Germline mutations in the MSH2 gene and MSH6 gene in genetic testing, was consistent with diagnosis of lynch syndrome. After some years the patient presented to our hospital for fever, shimmering and abdominal LUQ pain. The patient had dyspnea, coughing, and had lost some weight. Spiral CT scan showed a solid cyst with heterogeneous enhancement in spleen, and hepatosplenomegaly.In this paper, another case with endometrial cancer as a sentinel cancer of lynch syndrome is reported. This fact implicate that physicians should notice the family history of malignancies in patients with gynecologic cancers and consider lynch syndrome. Many case reports have been published, but any of them have not been reported spleen involvement yet.
Soudabeh Kazemi Aski,; Seyedeh Hajar Sharami; Azadeh Tavangar; ehsan Kazem Nezhad Leilie; Seyedeh Fatemeh Dalil Heirati; Atoosa Etezadi
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background and objective: The initial diagnosis of predictive markers is essential for the IUGR. High levels of PAPP-A lead to increased levels of free IGF-1, which in turn reflects the function of the placenta and the fetus normal growth. The objective of this study was to compare the level ...
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Background and objective: The initial diagnosis of predictive markers is essential for the IUGR. High levels of PAPP-A lead to increased levels of free IGF-1, which in turn reflects the function of the placenta and the fetus normal growth. The objective of this study was to compare the level of PAPP-A in pregnancy weeks 11-14 in women with and without intrauterine growth restriction and to assess the ability of this marker to predict adverse outcomes in pregnancy. Methods: In this Comparative Cross-sectional study, 227 pregnant women were studied during 2017. Mothers were divided into two main groups with and without intrauterine growth restriction. The relevant data, including birth weight, preeclampsia, gestational diabetes, Apgar score, and PAPP-A, were recorded on special forms. Data analysis was done using SPSS-21 software. Results: The mean age of participating women in this study was 28.8 ± 5.6 years. The median (IOR) number of gravidity and Gestational weight gain was 1 (1) and 12 (7) kg respectively. The difference in median (IOR) PAPP-A in patients with and without IUGR was statistically significant 0.64(0.57) and 1 (0.57), respectively, P= 0.001.The cut-off point for PAPP-A was 0.73 with a sensitivity=72.2% (95% CI: 64.32-79.16%) and a specify =60.5% (95% CI: 48.65 -71.56%). Conclusion: The results of this study confirm the relationship between low levels of PAPP-A and adverse outcomes of pregnancy. In the present study, the optimal cut-off point (0.73) is higher than other studies, which can be due to racial and epidemiological differences.
Maryam Nurzadeh; Maryam Moshfeghi; mamak shariat; Ashraf Jamal; Vajiheh Marsosi; Laleh Eslamian; Mahsa Naemi; Maria Nezam Nia; Fedyeh Haghollahi; Seyede Houra Mousavi Vahed
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background:A number of procedures have been developed for multifetal pregnancy reduction (MPR) to reduce the overall number of fetuses in the gestation and improve the maternal outcomes as well as the outcomes of the surviving fetus. Methods and material:An observational historical cohort study was conducted ...
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Background:A number of procedures have been developed for multifetal pregnancy reduction (MPR) to reduce the overall number of fetuses in the gestation and improve the maternal outcomes as well as the outcomes of the surviving fetus. Methods and material:An observational historical cohort study was conducted on multiple pregnancies that underwent fetal reduction in Shariati Hospital and Omid Clinic between January 2018 and September 2021. The study population was divided into two groups according to gestational age at fetal reduction: 11–14 weeks' gestation (early reduction group < /span>) and 15–19 weeks’ gestation (late reduction group). The main outcome measures were the rates of pregnancy complications, pregnancy loss, preterm delivery, and adverse neonatal outcomes.Results:The study group included 107 patients with twin and multiple pregnancies that underwent abdominal MPR at 11-19 weeks’ gestation (79 in the early reduction group and 28 in the late group).The incidence of pregnancy complications (hypertension, diabetes, intrauterine growth disorder, preterm delivery, pregnancy loss) was not significantly different between the two groups (p>0.05). The percentage of NICU admission was higher in the early reduction group compared to the late group (49% vs 18.5%, p=0.004)The weight of the first newborn was significantly heavier in the late versus early reduction group (2680.55±777.52 vs 2264.4±796.82, p=0.005)Conclusion:According to the present study, fetal reduction in twin or multiple pregnancies is a safe procedure with good obstetric outcomes if done by an expert specialist, especially when it is performed in the second trimester.
Batool Hossein Rashidi; marjan ghaemi; Ensieh Shahrokh Tehrani; Marzieh Mohebbi; Marzieh savari
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Objective: Preserving fertility in women with cancer before therapeutic interventions is very important. Method: Participants were females with an approved cancer diagnosis of reproductive ages that were referred for fertility preservation. After proper counseling by an expert team, the final decision ...
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Objective: Preserving fertility in women with cancer before therapeutic interventions is very important. Method: Participants were females with an approved cancer diagnosis of reproductive ages that were referred for fertility preservation. After proper counseling by an expert team, the final decision on the fertility preservation method was made based on the patient's condition and survival expectation. The primary goal was to collect data about the fertility, clinical and survival outcomes of these women and pregnancy rate as a secondary objective that were compared between cancer types.Results: Totally 337 participants were recruited. Gynecological cancers accounted for 166 (49.3%) of all cases followed by breast (107 (31.8%)) and other cancers (64 (19.0%)) respectively. Of those, 144 (42.7%) cases entered into the ovulation induction cycle and the others did not continue due to lack of correct information and late referral, and inability to postpone treatment as the major reasons. Comparing between 3 groups (gynecological, breast and other cancers), a higher rate of pregnancy otherwise not statistically different was detected in gynecological cancer survivors. In the breast cancer survivors, the chance of oocyte retrieval and fertility was not lower than in other cancers.Conclusions: Many patients and even their therapists are unfamiliar with the methods of fertility preservation, and when they consider it, the golden time is usually passed. Therefore, having a good consultation with the survivors and patient education may be the most important issue that led to a timely referral for preserving fertility in cancer patients.
Mahdi Seyfi-Ghale-Jogh; Marjan Mehrali; Fatemeh Mohammadyari; Rezvaneh Rakhshanimehr; Elahe Safari; Mohammad Salehi-Shadkami; Sepehr Nanbakhsh; Katayoun Haryalchi
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background/objective: The COVID-19 pandemic has disrupted people’s lives all over the world and vaccination is one of the best ways to eradicate this pandemic and save people’s lives. Despite this, vaccines have many known and unknown side effects like fever, fatigue, headache, etc. Fertility ...
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Background/objective: The COVID-19 pandemic has disrupted people’s lives all over the world and vaccination is one of the best ways to eradicate this pandemic and save people’s lives. Despite this, vaccines have many known and unknown side effects like fever, fatigue, headache, etc. Fertility is an important aspect of human life with too many concerns about its relation with COVID-19 and its vaccines. Women are complaining of menstrual irregularities like postmenopausal bleeding, heavy menstrual bleeding, polymenorrhea and fertility concerns after receiving the second dose of COVID-19 vaccine. The immunologic reactions between vaccines’ ingredients and immune system of the body, seem to be responsible for this global issue. Angiotensin-converting enzyme 2 (ACE2) and Basigin (BSG) are the receptors for SARS-COV-2. ACE2 is expressed in human respiratory system, kidney, vagina, uterus and particularly widely in the ovaries; and BSG is expressed in the uterus, ovary stroma and granulosa cells. Therefore, SARS-COV-2 can invade the target cells by attachment to ACE2 and BSG, and modulate their expression and through these probable mechanisms, it can disturb female reproduction and menstruation. Conclusion: According to these accumulated evidences, in this study, we aimed at summarizing the recent studies with focus on probable mechanisms which SARS-COV-2 and COVID-19 vaccines affect menstruation irregularities and reproduction complications.
zinat ghanbari; leila pourali; Tahereh Eftekhar; maryam deldar pesikhani; soudabeh darvish; zahra lotfi; elnaz ayati
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Introduction: Defecatory dysfunction is a common problem among women who referred for urogynecological care. Pelvic organ prolapse (POP) which is a downward displacement of pelvic organs is one of the common condition among patients with defecatory problems . This study was planned to evaluate the correlation ...
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Introduction: Defecatory dysfunction is a common problem among women who referred for urogynecological care. Pelvic organ prolapse (POP) which is a downward displacement of pelvic organs is one of the common condition among patients with defecatory problems . This study was planned to evaluate the correlation of obstructive defecatory symptoms with the site and severity of pelvic organ prolapse and the anorectal manometry results.Methods: This cross-sectional study was performed between Dec 2018 and Nov 2019. About 150 women with symptoms of defecatory problems were enrolled. Patients were classified in two groups according to each compartment prolapse staging and severity; stage ≤2 and stage >2. The correlation between defecatory symptoms and pelvic organ prolapse examination, anorectal examination and anal manometry were evaluated.Results: A total of 150women were evaluated. There was a significant correlation between higher stage of anterior compartment prolapse (cystocele stage>2) and constipation (P=0.035). Although all the defecatory symptoms were more frequent in anterior prolapse stage>2, but the difference was not significant (P>0.05).There was no significant correlation between defecatory symptoms and severity of posterior compartment prolapse. There was a significant correlation between stage>2 of apical prolapse and all the defecatory symptoms (P≤0.05). The abnormal anal resting and squeeze pressure and also abnormal balloon expulsion test were more frequent in stage >2 of all compartment prolapse, but the difference was not significant (P>0.05).Conclusion:Obstructive defecatory symptoms were more frequent in patients with higher stage of anterior and apical prolapse. Abnormal manometry results were more frequent in patients with defecatory dysfunction with advanced vaginal prolapse.
Marzieh Talebian; Zohreh Talebi Mazreshahi; Elham Khosravi Mashizi; Nafiseh Khalili
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Introduction: Although 1% to 2% of all pregnancies are ectopic, ectopic pregnancy (EP) is the most frequent obstetrical disease leads to maternal mortality and morbidity at first trimester. The basic diagnostic method of EP is the human chorionic gonadotropin (HCG) test and transvaginal ultrasound. There ...
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Introduction: Although 1% to 2% of all pregnancies are ectopic, ectopic pregnancy (EP) is the most frequent obstetrical disease leads to maternal mortality and morbidity at first trimester. The basic diagnostic method of EP is the human chorionic gonadotropin (HCG) test and transvaginal ultrasound. There are some rare EP cases with negative HCG blood test. Case presentation: A 31-years old woman referred to the emergency department with hypogastric, periumbilical, and right upper quadrant intermittent pain and vaginal bleeding and prior history of EP 7-months ago that treated with methotrexate and her intra uterine device had been removed at that time. Her last menstrual period was undetermined. Although HCG blood test-qualitative was negative (2.08 IU /ml),ultrasound examination showed an 43×53 mm echogenic, heterogenic complex solid mass in the left adnexa and a large amount of echogenic fluid demonstrating hemoperitoneum. Taken surgery because of the exceeded abdominal pain revealed active bleeding in the left salpinx due to ruptured EP. Conclusion: Management of patients suspected of EP with negative HCG-blood test is difficult. In this uncommon cases in emergency, computed tomography, ultrasound and diagnostic laparoscopy or laparotomy can improve prognosis of patient.
Melad Alias Alsanity; Chiman Younus Hasan
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background: For decreasing unintended pregnancies and maternal mortality, women need to use contraceptive methods accurately. For choosing or discontinuation of any method, different factors may interfere with the options. The aim of the study was to predict factors influencing contraception in our community.Methodology: ...
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Background: For decreasing unintended pregnancies and maternal mortality, women need to use contraceptive methods accurately. For choosing or discontinuation of any method, different factors may interfere with the options. The aim of the study was to predict factors influencing contraception in our community.Methodology: A descriptive cross-sectional study was carried out in primary healthcare centers in Duhok city, period from 1st December 2021 to 1st April 2022. The studied sample was 400 married women aged between (18-45) years old. Information on sociodemographic, obstetrical, contraceptive methods used, factors of choosing, and discontinuation were obtained from respondents. The statistical calculations were performed in John's Macintosh Project (JMP) Pro 14.3.0.Results: Out of 400 women 269(67.25%) aged 18-34, 106(26.50%) completed primary education, and 204(51.00%) desire to conceive. Withdrawal was the most common used method 257(64.25%), oral contraceptive pills 43(10.75%), intrauterine device 39(9.75%), and male condom 35(8.75%). Discontinuation of contraceptives took place for the desire to get pregnancy 256(64.00%). Most of failure rate were seen among withdrawal users which recorded 77(19.25%), and those who experienced side effects were 42(10.50%).Conclusion: Educational program are requested to improve the behavior and attitude toward family control
Shahrzad Sheikhhasani; Maryam Noorzadeh; Mahsa Naemi
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background: Ovarian cancer is the second most common malignancy in women worldwide, causing many deaths each year. Chemotherapy is one of the most important therapeutic strategies that can increase the survival of these patients; however, one of the problems in chemotherapy is resistance against platinum ...
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Background: Ovarian cancer is the second most common malignancy in women worldwide, causing many deaths each year. Chemotherapy is one of the most important therapeutic strategies that can increase the survival of these patients; however, one of the problems in chemotherapy is resistance against platinum treatment. Evaluating the effect of platinum- and non-platinum-based chemotherapy in patients with recurrent platinum-resistant ovarian cancer can enhance our view on this issue. Methods: The present review article sought to identify the treating efficacy of platinum and non-platinum-based chemotherapy in patients with recurrent platinum-resistant ovarian cancer by searching scientific databases and examining the aspects of platinum resistance in various articles. Results: Oncological results have shown that ovarian cancer is a deadly disease, and most cases are diagnosed when the cancer spreads outside the ovary and often throughout the entire abdomen. On the other hand, in many cases disease recurrence is associated with drug resistance. The use of a platinum-free interval has played an important role in its treatment efficacy. Understanding the cause of platinum resistance and discovering strategies to reduce drug resistance, especially to new ones, is very important.Conclusion: The present article suggested oncology teams agree on treatment methods and the best treatment approach against platinum resistance in malignant ovarian cancers and offer a better treatment solution by considering innovative strategies.
Dhai Abdulalazize Rashid; Fadia Jassim Alizzi
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background: The endometrial receptivity is controlled by biomarkers, hormones, growth factors, and cytokines interaction, disorders in these biomarkers will affect endometrial receptivity and this may possibly have correlated with unexplained infertility, the aim of study is to assess the correlation ...
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Background: The endometrial receptivity is controlled by biomarkers, hormones, growth factors, and cytokines interaction, disorders in these biomarkers will affect endometrial receptivity and this may possibly have correlated with unexplained infertility, the aim of study is to assess the correlation between integrin Alpha v Beta3 expression, endometrial thickness and sub- endometrial blood flow resistance index in unexplained Infertility. Methods: case control study includes two group of woman, infertile women with unexplained infertility considered as a case group and fertile control group. The study carried out on Kamal – Al-Samurai fertility center in the period from October 2020 - September 2021. Six days after detecting urinary LH surge, asked to come to two do dimension 2D transvaginal ultrasound to assess endometrial thickness and sub-endometrial blood flow color Doppler resistance index and endometrial samples was taken and examined immunohistochemically to detect Alpha v Beta3 integrin. Result: total women enrolled in the study were 80. The endometrial thickness was lower and resistance index was higher in case group (p < /i> < 0.001). The expression of integrin Alpha v Beta3 in infertile group was significantly low ((p < /i> < 0.001) with significant positive correlation between integrin score and endometrial thickness (r= -0.708 & p < 0.001) and significant negative correlation between integrin score and sub-endometrial resistance index (r= -0.786 & p <0.001). Conclusion: Alpha v beta 3 integrin expressions and endometrial thickness are reduced significantly in mid-luteal phase while the sub endometrial blood flow color Doppler resistant index significantly increased, and using them together can possibly be used as a diagnostic predictor of unexplained infertility.
Mahin Najafian; Mahtab Shariati; Sara Masihi; Roshan Nikbakht
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Introduction: Hypertension during pregnancy is associated with significant negative outcomes. In this study, we evaluated the effectiveness of dietary approaches to stop hypertension (DASH) on pregnancy outcomes of pregnant women with gestational and chronic hypertension. Methods: This randomized controlled ...
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Introduction: Hypertension during pregnancy is associated with significant negative outcomes. In this study, we evaluated the effectiveness of dietary approaches to stop hypertension (DASH) on pregnancy outcomes of pregnant women with gestational and chronic hypertension. Methods: This randomized controlled clinical trial study was conducted on 60 pregnant women with a diagnosis of gestational hypertension and chronic hypertension. Women were randomly divided into the control (n=30) and the DASH diet (n=30) groups for 2 months and were followed until delivery. The outcomes of maternal pregnancy including the incidence of preeclampsia, placental abruption and preterm delivery (<37 weeks) were assessed during follow-up examinations. Birth weight and minute 1 and minute 5 Apgar score of the infant were also assessed. Results: After 1 and 2 months of intervention, systolic and diastolic blood pressure in the DASH diet group was significantly lower than the control group (P<0.05). The incidence of preeclampsia (P=0.035), preterm delivery (P=0.020) and placental abruption (P=0.007) in the DASH diet group was significantly lower than the control group. The mean gestational age at the time of termination of pregnancy was not significantly different between the two groups (P = 0.467). There was no significant difference between minute 1 and minute 5 Apgar scores of the infants and the mean birth weight of the infants was not significantly different between the DASH and control groups (P = 0.756, P = 0.115 and P = 0.101, respectively). Conclusion: The DASH diet could be used as an effective strategy to improve the clinical outcomes of pregnant women with gestational and chronic hypertension.
Sayedeh Elham Sharafi; Marzieh hajibabaei; Fatemeh Keikha; Ali Montazeri
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background & Objective: Oocyte donation is an assisted reproductive technique. The infertile couples' demand for using this technique have increased in recent years. This study aimed to evaluate psychiatric disorders, personality characteristics and intelligence quotient among women who are candidates ...
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Background & Objective: Oocyte donation is an assisted reproductive technique. The infertile couples' demand for using this technique have increased in recent years. This study aimed to evaluate psychiatric disorders, personality characteristics and intelligence quotient among women who are candidates for oocyte donation. Material & Methods: This was a cross sectional study. Thirty-nine parous women were entered into the study. A psychiatrist interviewed participants regarding to psychiatric axis I disorders. Also, participants were asked to answer the Millon Clinical Multi axial Inventory (MCMI III) and Raven’s Standard and Progressive Matrices (RSPM). Results: The mean age of participants was 28.79 (SD = 4.1) years and it was 11.17 years (SD = 2.6) for education. The mean of donation frequency was 1.35 (SD =0.6). Twenty-one donors (53.8%) had only financial motivation and eleven (28.2%) had only altruist object. Twenty-eight (71.8%) women did not have any psychiatric axis I disorders while eight women (20.5%) had at least one disorder. Eleven participants (28.4%) suffered from at least one personality disorder. The mean intelligence quotient was 99.3 (SD =14.2). Conclusion: The results showed that oocyte donors might suffer from mental disorders and intelligence quotient problems irrespective of age, education, job status and motivation for donation. In conclusion, it seems that psychological assessment and help service is necessary for oocyte donors before any donation procedure.
Nadia Azadi; Yousra Alsinani; Mohammad Hemmatinafar; Maryam Koushkie Jahromi
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Objectives: Some evidence has shown the beneficial effects of exercise on reducing menopausal symptoms. However, the effect of type of exercise (aquatic and land-based exercise) and cessation of exercise is still unknown. The aim of this study was to compare the menopausal symptoms in two aquatic and ...
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Objectives: Some evidence has shown the beneficial effects of exercise on reducing menopausal symptoms. However, the effect of type of exercise (aquatic and land-based exercise) and cessation of exercise is still unknown. The aim of this study was to compare the menopausal symptoms in two aquatic and land-based trained groups before and after cessation of exercise due to COVID-19 outbreak. Methods: 90 postmenopausal women participated in the study voluntarily. The daily and sport physical activities and menopausal symptoms were assessed through interviews three months after cessation of sport activities and Questions were designed and obtained from daily physical activity form and menopausal rating scale (MRS) questionnaire respectively. Results: Before the cessation of exercise, the somatic, psychological, and sexual symptoms of menopause were lower in both active groups than the inactive group, while there was no significant difference in three categories of menopausal symptoms between aquatic and land- based exercise groups. After the cessation of exercise, menopausal symptoms in the two groups of previously active women increased significantly compared to the inactive group, so that there was no significant difference in menopausal symptoms between exercise and inactive groups.Conclusion: aquatic and land-based exercise reduces the symptoms of menopause similarly, while the beneficial effects of exercise on menopausal symptoms can disappear after the cessation of exercise for three months.
Hossam El Sokkary
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background:. The present study compares between superficial and deep myometrial invasion in type 1 endometrial cancer in relation to regional lymph nodes metastasis, so we can answer the question to do or not do lymphadenectomy, this life-threatening procedure in both superficial and deep myometrial ...
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Background:. The present study compares between superficial and deep myometrial invasion in type 1 endometrial cancer in relation to regional lymph nodes metastasis, so we can answer the question to do or not do lymphadenectomy, this life-threatening procedure in both superficial and deep myometrial invasion with type 1, clinically and radiologically stage 1 endometrial cancer. Patients and methods: Patients were divided into 2 groups distributed as follows: group I includes 50 patients type 1 endometrial cancer with superficial myometrial invasion and group II includes 50 patients type 1 endometrial cancer with deep myometrial invasion. Total abdominal hysterectomy with bilateral salpingo-opherectomy with pelvic and lower para-aortic lymphadenectomy to all patients included in the study from both groups. Histopathological examinations were done to all the specimen from both groups to confirm diagnosis of type 1 endometrial cancer, depth of myometrial invasion, pathological grading and metastasis to the regional lymph nodes.Result: Considering regional lymph nodes metastasis in both groups, there is a statistical difference between group I and group II in relation to relation to regional lymph nodes metastasis as group II (cases with deep myometrial invasion) are associated with more regional lymph nodes metastasis (p= 0.0001)). Conclusion: deep myometrial invasion in type 1 endometrial cancer is associated with significant increase in regional lymph nodes metastases.
Mohammad Reza Javan; Bahareh Moghimian-Boroujeni; Hossein Ayatollahi; Amirali Ayatollahi; Nafise Amini; Elham Jafaei; maryam sheikhi; Narjes Soltani
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
AbstractBackground: Recurrent pregnancy loss (RPL) is the occurrence of three or more miscarriages before the 20th week of pregnancy. Thrombophilia factors are one of the main causes of RPL. Methods: This retrospectively study was performed on women with more than two miscarriages. 620 patients’ ...
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AbstractBackground: Recurrent pregnancy loss (RPL) is the occurrence of three or more miscarriages before the 20th week of pregnancy. Thrombophilia factors are one of the main causes of RPL. Methods: This retrospectively study was performed on women with more than two miscarriages. 620 patients’ documents with pregnancy loss were investigated. Based on number of pregnancy loss, the women divided to a control group with less than three miscarriages (212) and RPL group (180). Cytogenetics analysis and thrombophilia panel (MTHFR 677 C⁄T/ FV Leiden G1691A/Prothrombin G20210A (FII), ACE I/D, PAI1) were performed for all patients.Result: In the analysis between Control and RPL groups, none of the studied polymorphisms (MTHFR 677 C⁄T /Factor V Leiden /Prothrombin G20210A/ ACE I/D/ PAI-1) showed a significant relationship (P-value ˃ 0.05). Cytogenetic analysis showed 2 numerical and 9 structural abnormalities among both groups. Statistical analysis indicated significant association between number of abortion and age (P value= 0.005, r =0.139). We even realized that there was significant relationship between polymorphism number and recurrent number of abortion (P value= 0.018, r = 0.6).Conclusion: We showed that polymorphisms analysis for thrombophilia factors is more precious test than cytogenetics analysis for RPL detection due to frequency in pregnant woman. We even indicated that no association was found between thrombophilia polymorphisms in Control and RPL groups. This means that screening for Factor V Leiden, prothrombin G20210A, MTHFR C677T, ACE I/D and PAI-1 and cytogenetic analysis in patients with a history of RPL is not recommended.
Behnaz Nouri; Maliheh Arab; mohammad nasiri
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background and Objective: Endometriosis is one of the most common diseases in the female population. The range of diagnostic delays in this disease is long and leads to adverse health-related consequences. The aim of this study was to evaluate diagnostic experiences in patients with endometriosis who ...
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Background and Objective: Endometriosis is one of the most common diseases in the female population. The range of diagnostic delays in this disease is long and leads to adverse health-related consequences. The aim of this study was to evaluate diagnostic experiences in patients with endometriosis who are candidates for laparoscopic surgery.Methods: This cross-sectional study was performed on 433 patients with endometriosis who were candidates for laparoscopic surgery referred to Shohada-Tajrish Hospital in Tehran between January 2016 and December 2021. A questionnaire including demographic and clinical information, MRI, and pathology reports were collected from participants. The MRI lesions were segmented and the results were compared with pathology and clinical examination. For statistical analysis SPSS software, version 22 was used.Results: A total of 433 patients in this study with a mean age of 34.18±7.99. The average estimated duration of disease symptoms (months) was 40.58±42.33. The predictive value of clinical symptoms is weak compared to MRI. However, the probability that the disease is not present when the clinical signs be negative is acceptable in most of the endometriosis sites. MRI considerably shows the true negative rate, but its sensitivity is only relatively acceptable for the diagnosis of ascites (67.66%). Calculating the accuracy of MRI reports probably shows the overall classification of the patients via MRI test.Conclusion: despite extensive research, there are no suitable and accurate non-invasive methods for diagnosing endometriosis. MRI and clinical examination alone are not useful for definitive diagnosis and it is better to examine biomarkers and artificial intelligence for non-invasive and accurate diagnosis of this disease.
Roya KaboodMehri; seyedeh hajar sharami; Sodabeh Kazemi; Mandana Mansour Ghanaei; Seyedeh Fatemeh Dalil Heirati; Zahra Pourhabibi; Sina Montazeri
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background and objective: Anti Mullerian hormone (AMH) level is a practical index of ovarian reserve and an indicator of ovarian response in infertile women. The aim of this study was to evaluating relationship between AMH levels and demographic factors.Methods: In this cross-sectional ...
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Background and objective: Anti Mullerian hormone (AMH) level is a practical index of ovarian reserve and an indicator of ovarian response in infertile women. The aim of this study was to evaluating relationship between AMH levels and demographic factors.Methods: In this cross-sectional study, conducted in Al-zahra hospital Rasht in the north of Iran, 234 patients, 18-45 years old, were enrolled. The demographic parameters (e.g. age, education, habitat and etc.) and AMH levels were recorded for each patient. The patients were devided into two groups based on their AMH levels [group 1:less than 1.1 (ng/ml) vs. group 2:more than (1.1 ng/ml)].The data were analyzed by SPSS-21 software.Results: The mean AMH level was 2.66 ng/ml. Age, education status and habitat showed significant differences among subjects with AMH levels, so that with aging the AMH levels decreased. Patients living in villages or the ones with low educational degrees and those with higher parities also revealed lower levels of AMH (p<0.05).Conclusion: There was a significant relationship between age, educational status and habitat with AMH values. Similar to other studies, we believe, that with aging the AMH levels decrease. Furthermore, the other two aforementioned demographic features could affect a woman’s ovarian reserve and fertility status, too.
Fatemeh Bahadori; Zahra Sahebazzamani; Somayeh Ghasemzadeh; Zahra Kousehlou; Leila Zarei; Marjan Hoseinpour
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
AbstractBackground& Aims:Menarche is an important stage in the development of girls which can predict the adolescent’s puberty process and fertility onset. The changes in adolescence have health consequence not only in adolescence but also over the life-course. Childhood obesity as a common ...
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AbstractBackground& Aims:Menarche is an important stage in the development of girls which can predict the adolescent’s puberty process and fertility onset. The changes in adolescence have health consequence not only in adolescence but also over the life-course. Childhood obesity as a common health problem has been observed in both developed and developing countries and its prevalence is continuing to increase. The aim of this study was to identify menstrual patterns and related disorders and also to investigate the relationship between menarche age, menstrual disorders, and (BMI) in high school girls in Urmia.Materials& Methods:In this cross-sectional study 716 adolescent girls aged 14-18 years were selected with multistage sampling from high schools of Urmia. (Sept 2012 to Dec 2013) Participants completed the questionnaire of menstrual pattern characteristics including age at menarche, menstrual cycle length, dysmenorrhea, and the need for pain relief. BMI percentile was calculated and obesity was determined using the CDC’s 2000 BMI-for-age growth charts.Result:The results showed that the average of age, BMI, and menarche age were: 15.66±1.019 year, 22.05±3.91.kg/m2 and 12.87±0.98 year, respectively. The prevalence of overweight and obesity were 13.7% and 8.4%, respectively. A large majority of the subjects (76.1%) had normal, healthy weight. There was a significant association between BMI and the duration of flow, menarche age, menstruation flow, and pain severity (P<0.05).Conclusion:Based on the results, planning and intervention for decreasing the BMI in high school girls can help reduce menstrual disorders. Future studies are required to confirm and complete our results.
Atefeh Kazemi; Vahideh Rashtchi; Masoomeh Ghomi
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background: Types of major surgeries are associated with postoperative pain sometimes during the days after surgery. These pains mainly lead to the use of various analgesics and ultimately patient dissatisfaction. In the present study, we evaluated the effect of gabapentin at doses of 600 and 1200 mg ...
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Background: Types of major surgeries are associated with postoperative pain sometimes during the days after surgery. These pains mainly lead to the use of various analgesics and ultimately patient dissatisfaction. In the present study, we evaluated the effect of gabapentin at doses of 600 and 1200 mg in relieving pain due to cesarean section.Methods: In this randomized clinical trial patients were randomly divided into three equal-size groups (25 patients in each group) through balanced block randomization. The first group was given 600 mg of gabapentin the second group was given 1200 mg of gabapentin one hour before surgery and the control group received a placebo. The pain intensity, occurring nausea/vomiting and drowsiness, as well as needing postoperative analgesics were assessed initially and at 2, 6, and 12 hours after surgery. The occurrence of nausea and drowsiness between groups was compared using chi-square and exact fisher teat.Results: The mean (SD) age of patients in the gabapentin 1200 mg, gabapentin 800 mg, and placebo groups were 26.32±6.15, 27.43±6.38, and 26.59±5.88, respectively (P=0.34). Pain intensity and also the rate of analgesic consumption at the different time points during the first 12 hours of surgery were significantly lower in the receiving gabapentin groups compared to the placebo group (P<0.05). Comparing the prevalence rates of nausea and vomiting and also drowsiness as the drug-related side effects don’t show a significant difference across the three groups at the different investigated time points (P>0.05). Conclusion: Gabapentin with a minimum therapeutic dose can successfully reduce postoperative pain intensity and also needs analgesics use after cesarean section.
Marzieh Mehrafza; Azadeh Raoufi; Tahereh Zare Yousefi; Elmira Hosseinzadeh; Sajedeh Samadnia; Amirhossein Tamimi; Ahmad Hosseini
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Background and Objective: Repeated implantation failure (RIF) is still remain an ongoing challenge. RIF may be contributed to the embryo or the endometrium, which any abnormalities of each two may result implantation failure. The aim of present study was to report the effect of endometrial injury (EI) ...
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Background and Objective: Repeated implantation failure (RIF) is still remain an ongoing challenge. RIF may be contributed to the embryo or the endometrium, which any abnormalities of each two may result implantation failure. The aim of present study was to report the effect of endometrial injury (EI) during frozen embryo transfer (FET) on pregnancy outcome in RIF patients.Material and methods: In this retrospective case series, since 2018 to 2020, 20 patients with a history of RIF who underwent EI during FET cycle were evaluated. Results: Chemical, clinical and ongoing pregnancy and live birth was achieved in 8 (40%), 7 (35%), 6 (30%) and 6 (30%) patients, respectively.Conclusion: The present study shows that using EI in FET cycle is a feasible, safe and efficient method in improving clinical outcomes. More researches are needed to find out the real effect of EI during FET in RIF patients.
ahmed elkhyat; amal elsokary; shereef elshwaikh
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Objective: To evaluate the effect of weight gain in lean patients with polycystic ovary syndrome (PCOS) on ovulation and pregnancy rates.Study design: A prospective observational study.Patients: Lean patients with PCOS seeking fertility were invited to participate in the study. Weight gain was commenced ...
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Objective: To evaluate the effect of weight gain in lean patients with polycystic ovary syndrome (PCOS) on ovulation and pregnancy rates.Study design: A prospective observational study.Patients: Lean patients with PCOS seeking fertility were invited to participate in the study. Weight gain was commenced by dietary modifications. Patients were classified later into respondent and non-respondent. All patients were stimulated with letrozole 2.5 mg twice daily for 5 days for 6 cycles. Ovulation and pregnancy rates were assessed. Results: From 84 patients who were enrolled in our study, 33 patients were allocated into non responder group and 28 patients were allocated in responder group and It was found that despite there was statistical difference between both group as regard weight gain , weight after 6 months and BMI after 6 months , there was no significant difference between both groups as regard the ovulation rate , pregnancy rate and complications to ovulation induction (OHSS).Conclusion: weight gain in lean PCOS patients - although non-significant- but it may improve the reproductive outcomes (ovulation rate and pregnancy rate) and the need of further study with larger number and longer duration of follow up for confirmation of this results.
marjaneh zarkesh; Mandana Mansour Ghanaei; Marjan Malekifard; MARYAM GHALANDARI
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
Objectives: We aimed to compare the correlation between nucleated red blood cell (NRBC) and creatine kinase (CK) levels with hypoxic-ischemic encephalopathy (HIE) in asphyxiated newborns.Materials and Methods: This case-control study included 30 asphyxiated (case) and 30 healthy neonates (control) ...
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Objectives: We aimed to compare the correlation between nucleated red blood cell (NRBC) and creatine kinase (CK) levels with hypoxic-ischemic encephalopathy (HIE) in asphyxiated newborns.Materials and Methods: This case-control study included 30 asphyxiated (case) and 30 healthy neonates (control) born at Al-Zahra Hospital in Rasht, Iran. We collected the cord blood samples for CK level and NRBC at birth. The clinical stage of Sarnat indicated the severity of HIE. Data were analyzed in the two groups using IBM SPSS Statistics for Windows, version 22. Results: The case group had a higher NRBC count (P=0.001). The CK level was significantly different between the two groups and was higher in the case group than in the control group (P= 0.002). Results demonstrated a significant association between NRBC count and the occurrence of HIE in neonates with asphyxia (P = 0.021). Besides, a positive correlation was found between HIE and CK levels in the case group (r = 0.7, P=0.001).Conclusion: According to our results, NRBC count and umbilical cord CK level measurement are valuable predictors of asphyxia and HIE in neonates. In addition, measuring these parameters may help clinicians for faster diagnosis and better management.
Original Research Article
Omarov Nazarbek Bakytbekovich; Ahmed Al-Hili; Duaa Hamid Ali; Aisha Kamal Mahmoud; Entsar Hachim Muhammad; Ahmed S. Abed; Marwa Jabbar Saiwan; Haider Hussain Jlood
Articles in Press, Accepted Manuscript, Available Online from 08 February 2023
Abstract
The present semi-experimental study was conducted in 2019 on 192 Baghdad-based women aged 20 to 60 with active medical records. Two groups of 96 people, intervention and control, were created. The intervention group received training based on the constructs of health belief and stages of change models ...
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The present semi-experimental study was conducted in 2019 on 192 Baghdad-based women aged 20 to 60 with active medical records. Two groups of 96 people, intervention and control, were created. The intervention group received training based on the constructs of health belief and stages of change models to enhance Pap smear screening behavior. The control group participated in routine training on Pap smear screening behavior in health centers from health professionals. The participants completed a questionnaire created by the researchers in the pre-test and post-test stages. For data analysis, version 19 of SPSS statistical software and independent t-tests, paired t-tests, chi-square, and Fisher's exact test were utilized.A p-value of less than 0.05 was deemed statistically significant. Before the educational intervention, there was no significant difference between the two groups in the stages of behavior change (P>0.05). However, after the educational intervention, the intervention group significantly differed from the control group in the Pap smear screening change (P<0.01). Also, based on the paired t-test, the mean scores of the intervention group's knowledge, susceptibility, severity, barriers, and self-efficacy were significant before and after the intervention (P<0.05). After the intervention, the intervention group demonstrated significantly higher Pap smear screening behavior than the control group (P<0.01).The utilization of educational intervention of the stages of change and health beliefs models has proven to be highly effective in bringing individuals to the action stage.
Original Research Article
Akhmetzhanova Dinara Oralgazyevna; Entsar Hachim Muhammad; Mohammed Ali; Ahmed Jalil Kadhim; Ayad Abas Hasan; Fathi Jihad Hammady; Noora M. Hameed; Hayfaa Attia Thijail
Articles in Press, Accepted Manuscript, Available Online from 08 February 2023
Abstract
Background & Objective: Episiotomy complications include infection, pain, hematoma, and third- and fourth-degree tears, and all primiparous women must undergo this procedure routinely. The current study aimed to compare the length of perineal tears in women referred to the Basra maternity hospital ...
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Background & Objective: Episiotomy complications include infection, pain, hematoma, and third- and fourth-degree tears, and all primiparous women must undergo this procedure routinely. The current study aimed to compare the length of perineal tears in women referred to the Basra maternity hospital in 2020 for their first births with and without episiotomy. Materials & Methods: The current clinical trial study involved 212 full-term, singleton, primiparous women with cephalic fetuses weighing between 2500 and 3000 grams. Randomly and evenly, the samples were divided into two test and control groups. In the test group, delivery occurred without an episiotomy, whereas in the control group, an episiotomy was performed. The length of the posterior perineal tear, the presence of an anterior perineal tear, and the necessity for repair were subsequently compared. Results: The results revealed that 45.3% of women in the test group gave birth without perineal tears, while the remainder experienced posterior perineal tears (P<0.001). The mean length of posterior perineal tears in this group was 3.64±1.15 cm, compared to 7.12±1.67 cm in the control group (P<0.001). The mean length of a second-degree tear behind the perineum in the test group was 5.32±1.17 cm, compared to 6.13±1.62 cm in the control group (P>0.05). Conclusion: Delivery without episiotomy decreased the incidence of posterior perineal tears; however, delivery without episiotomy should not be performed on all primiparous women.
Original Research Article
Alsmadi Yaseen Mohammad Ibrahim; Saad Altimimi; Aisha Kamal Mahmoud; Muqdad Hussein Ali; Naseer Mehdi Mohammed; Ruqayah Taher Habash; Ahmed S. Abed; Entsar Hachim Muhammad
Articles in Press, Accepted Manuscript, Available Online from 08 February 2023
Abstract
Background & Objective: Today, the prevalence of cervical cancer in developing societies and its impacts on various body functions, mainly sexual performance, is of particular significance. In order to examine the relationship between sexual function and its domains with different stages of cervical ...
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Background & Objective: Today, the prevalence of cervical cancer in developing societies and its impacts on various body functions, mainly sexual performance, is of particular significance. In order to examine the relationship between sexual function and its domains with different stages of cervical cancer, the present study was conducted.Materials & Methods: Examined in the current study were 284 women with cervical cancer referred to the Baghdad Women's Hospitals and selected randomly. The personal profile form and the female sexual function index (FSFI) were among the research instruments. The data were investigated by statistical software SPSS.23 and the Spearman correlation coefficient test. A p-value of less than 0.05 was deemed statistically significant.Results: The results revealed that 26.8% of women complained of low sexual desire, 43.0% did not receive adequate sexual arousal, and 39.1% experienced deficient vaginal lubrication. Additionally, 46.8% of women did not experience a proper orgasm, 27.8% were dissatisfied with their sexual satisfaction, and 37.0% reported experiencing pain during intercourse. In addition, there was an inverse correlation between the stages of cervical cancer and sexual performance (r= -0.25, P= 0.002), as well as its domains, including sexual desire (r= -0.18, P= 0.02), sexual arousal (r= -0.23, P= 0.004), vaginal lubrication (r= -0.23, P= 0.003), orgasm (r= -0.20, P= 0.009), sexual satisfaction (r= -0.21, P= 0.005), and pain during intercourse (r= -0.26, P= 0.001).Conclusion: The sexual performance of cervical cancer patients is impaired, and the more advanced stages of the disease weaken sexual performance and its domains.
Original Research Article
Berikuly Duman; Ali Abdulhussain Fadhil; Samah Sajad Kadim; Ayad Abas Hasan; Naseer Mehdi Mohammed; Ebtihal Sattar Qasim; Tamara Muayad Abdullah
Articles in Press, Accepted Manuscript, Available Online from 09 February 2023
Abstract
Background & Objective: Preeclampsia is related to numerous maternal and fetal complications, like intrauterine increase restriction, preterm delivery, and a raised danger of baby death. In order to determine the predictive amount of uterine artery Doppler sonography indices for neonatal complications ...
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Background & Objective: Preeclampsia is related to numerous maternal and fetal complications, like intrauterine increase restriction, preterm delivery, and a raised danger of baby death. In order to determine the predictive amount of uterine artery Doppler sonography indices for neonatal complications in pregnant patients with preeclampsia, the present study was conducted.Materials & Methods: In 2020, in Alwiyah Hospital for Obstetrics and Gynecology in Baghdad, 87 pregnant women with preeclampsia and 160 healthy pregnant women participated in the present prospective study. The Doppler signal of the uterine arteries was evaluated during a supine abdominal Doppler ultrasound examination executed between 26 and 36 weeks of pregnancy. The survey form was updated with information about the birth of the children following the termination of the pregnancy. The data were evaluated using SPSS.19 and independent t, Mann-Whitney, and chi-square tests.Results: The mean uterine artery pulsatility index of mothers with preeclampsia had the greatest sensitivity, specificity, and positive predictive amount of predicting a baby's low birth weight at 54.8%, 87.3%, and 91.6%, respectively. In addition, the sensitivity, specificity, and positive predictive amount of the mean uterine artery resistance index for predicting a baby's low birth weight were 65.2%, 96.4%, and 95.4%, respectively.Conclusion: Although uterine artery indices in Doppler ultrasound do not have a high sensitivity for predicting neonatal complications, abnormal indices can predict low birth weight with high confidence.
Original Research Article
Sahar Hassan; Nassrin Malik Aubead
Articles in Press, Accepted Manuscript, Available Online from 16 February 2023
Abstract
Background: Congenital anomalies are a global issue and the primary reason of death in both developed and advanced countries. Congenital anomalies occur at varying rates in various populations.Objective: The purpose of this study was to determine the prevalence and pattern of congenital anomalies ...
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Background: Congenital anomalies are a global issue and the primary reason of death in both developed and advanced countries. Congenital anomalies occur at varying rates in various populations.Objective: The purpose of this study was to determine the prevalence and pattern of congenital anomalies in newborns, as well as the associated maternal and environmental factors, in newborns presented at the Babylon teaching hospital for motherhood and pediatrics in AL-Hilla city between 2017 and 2021.Methodology: This study follows a descriptive design, was based on population data from the statistic registry covering the AL-Hilla city, Iraq, 2017 to 2021. The registry covers live, still births also maternal and neonatal information regarding sex, birth weight, parental consanguinity, maternal age, were recorded. After clinical examination, if required, were done to confirm diagnosis.Results: There were 214 congenitally deformed newborns among the 46,777 births in AL-Hilla city. There were 109 men (50.69 percent) and 103 women (47.90 percent). The most common congenital malformations discovered were those relating to the neurological system, followed by those relating to the musculoskeletal system.Conclusion: Anomalies in the central nervous system were most apparent, however, the research was able to supply a rough estimate of the prevalence of congenital anomalies in AL-Hilla city and identify their main types which could be important for informing public policy and clinical practice.
Case Report Article
Azar Danesh Shahraki; Leila Mousavi Seresht; Amir Reza Farhadi Dehkordi; Pegah Hedaiat; Fedyeh Haghollahi
Articles in Press, Accepted Manuscript, Available Online from 26 February 2023
Abstract
Invasive angiomyxoma as a mesenchymal tumor with a high recurrence rate has been reported mainly in reproductive age according to its association with the estrogenic level of plasma. Above that, it seems there is a need for further treatment despite complete resection of the tumor, to eliminate the hormonal ...
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Invasive angiomyxoma as a mesenchymal tumor with a high recurrence rate has been reported mainly in reproductive age according to its association with the estrogenic level of plasma. Above that, it seems there is a need for further treatment despite complete resection of the tumor, to eliminate the hormonal state.In the present study, we sought to introduce a rare case of invasive angiomyxoma in a post-menopausal but high-risk woman, discuss the relativity of risk factors in all hormonal-dependent gynecological malignancy, and intend to seek help from colleagues' opinions and experiences about treatment. It is clearly of great importance to emphasize the role of individualized medicine in such a rare case, in conclusion, there is not any debate on the role of surgical resection but the necessity of changing in lifestyle or adjuvant systemic or local therapy, and the needed duration is doubtful.
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