Sara Masihi; Elahe Shirazi; Farideh Moramezi; Najmieh Saadati; Mojgan Barati
Articles in Press, Accepted Manuscript, Available Online from 14 November 2022
Abstract
AbstractPurpose: This study aimed to compare CGH array and karyotype for prenatal diagnosis in high-risk individuals in the first trimester screening.Materials and Methods: The present cross-sectional descriptive prospective study was performed on high-risk mothers screened in the first trimester of ...
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AbstractPurpose: This study aimed to compare CGH array and karyotype for prenatal diagnosis in high-risk individuals in the first trimester screening.Materials and Methods: The present cross-sectional descriptive prospective study was performed on high-risk mothers screened in the first trimester of pregnancy. Individuals were allocated into two groups under karyotype and CGH array. Because this study is based on genetic testing data, it does not require a follow-up. Information on age, number of pregnancies, history of abortion, history of disease and screening results were collected and analyzed. Data analysis was done using SPSS Version 22 (IBM).Results: In total 247 cases were analyzed with 128 cases in the karyotype group and 119 cases in the CGH group. 116 samples (90.6%) in the karyotype group and 99 samples (83.2%) in the CGH group showed a normal karyotype. 4.2% (5 samples) and 7.9% (10 samples) of chromosomal abnormalities were trisomy in the CGH group and the karyotype group, respectively. CGH array analysis on chromosomal abnormalities identified copy number variation (CNV) in about 9.2% (11 samples) of cases. In terms of risk factors structural chromosomal, there was a statistically significant relationship in terms of history of disabled children in the family, maternal age, history of anomalies, screening of the first trimester of pregnancy, and increased NT (p<0.05).Conclusions: High-resolution arrays specifically prevented fetal malformations. Until now, normal prenatal chromosome analysis has been shown a relatively standard method but CGH may be helpful to specialists in diagnosing chromosomal abnormalities, especially in unknown chromosomal abnormalities.
Obstetrics and Gynecology
Farzaneh Rashidi Fakari; Zahra Kiani
Volume 6, Issue 3 , June 2021, , Pages 143-146
Abstract
COVID‐19 is a novel viral pandemic. It is believed that due to physiological changes within the pregnancy, pregnant women may be more susceptible to COVID-19. Currently, there exists no reliable evidence being available regarding the likelihood of infection for pregnant women compared to the general ...
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COVID‐19 is a novel viral pandemic. It is believed that due to physiological changes within the pregnancy, pregnant women may be more susceptible to COVID-19. Currently, there exists no reliable evidence being available regarding the likelihood of infection for pregnant women compared to the general population. On the other hand, given the previous experiences with SARS and MERS, pregnant women are likely to be at high risk for COVID-19 and its complications. Comparing the results of studies on COVID-19 during pregnancy and that of the general population, it can be concluded that pregnant women develop COVID-19 at a younger age than the general population. The results showed that due to changes during pregnancy, pregnant women have a higher risk for COVID-19 than other people, perhaps due to the lower mean age of COVID-19 in pregnant women, this leads to less COVID-19 on the adverse pregnancy outcomes.
Malihe Hasanzadeh; Shahnaz Ahmadi
Volume 1, Issue 2 , September and October 2016
Abstract
Background: Human papillomavirus (HPV) is thought to be the most common sexually transmitted viral disease. This infection continues to be an important topic. One of the most important conferences on human papillomavirus infection and related cancers is EUROGIN. The program also includes state of the ...
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Background: Human papillomavirus (HPV) is thought to be the most common sexually transmitted viral disease. This infection continues to be an important topic. One of the most important conferences on human papillomavirus infection and related cancers is EUROGIN. The program also includes state of the art science on anogenital and head and neck cancer, inspiration, cooperation, and forums to share expertise and learn from leading experts in the field.
Methods: We reported an abstract of important articles and researches presented in this congress.
Results: HPV had rolled in oropharyngeal cancer. KI67/P16 is important for deciding on treatment of patients with HPV high-risk positive. Methylation can be used in the management of HPV high-risk patients. 9-valent HPV vaccination can prevent different anogenital cancers.
Conclusions: HPV has important role in different cancers. HPV vaccination can prevent a variety of anogenital cancers related to HPV.
