Background: It seems that some herbal medicines such as sage or vitagnus traditionally used as treatment agents are eﬀective on menopausal symptoms such as hot ﬂashes; therefore, the current study aimed at assessing the eﬀect of vitagnus on menopausal symptoms.
Methods: The current study was a prospective clinical trial conducted on 100 menopausal patients divided into 3 groups. In each group, hot ﬂash was treated with vitagnus, sage, or placebo pills and patients were followed-up at the days 15 and 30 after the treat- ment. The data were analyzed by descriptive (percentage, mean, and standard deviation) and inferential (chi-square, t-test, McNa-mara, repeated ANOVA) statistics with SPSS software, version 21 (IBM SPSS, Armonk, NY, USA).
Results: Average of hot ﬂash in vitagnus group was 55.19 ± 14.53; it was also 60.26 ± 14.44 and 60.73 ± 12.30 in the sage and control groups. According to the Cooperman questionnaire score, comparison of hot ﬂash data showed no signiﬁcant diﬀerence between the groups before treatment (the Cooperman questionnaire score < 14) (P = 0.894), (15 - 20) (P = 0.262), (21 - 35) (P = 0.800), (35 < the Cooperman questionnaire score) (P = 0.867). The current study analysis showed no signiﬁcant diﬀerence between the groups in the severity of menopause symptoms at 15-day follow-up (the Cooperman questionnaire score < 14) (P = 0.477), (the Cooperman’s questionnaire score 15 to 20) (P = 0.620), (the Cooperman questionnaire score 21 to 35) (P = 0.243), (35 < the Cooperman questionnaire score) (P = 0.278). But, the severity of menopause symptoms at 30-day follow-up showed signiﬁcant diﬀerences between the groups, except between 15 - 20 and 21 - 35 scores (the Cooperman questionnaire score < 14) (P = 0.306), (15 - 20) (P = 0.005), (21 - 35) (P = 0.007), (35 < the Cooperman questionnaire score) (P = 0.785).
Conclusions: The results of the current study showed that vitagnus and sage were eﬀective on the reduction of menopausal symptoms in postmenopausal females. The eﬀect of placebo on the improvement of menopausal symptoms was signiﬁcant and it is recommended to be used as an agent to reduce the psychological outcomes of menopause.