Hysteroscopy is a common diagnostic procedure which is done to detect abnormal uterine conditions such as fibromas, intrauterine adhesions, polyps, intrauterine septum, and other congenital uterine anomalies (1, 2).Intrauterine fibromas, adhesions, and polyps may be resected by surgical hysteroscopy and the congenital anomalies and abnormal uterine bleedings may be diagnosed and treated by this exam (3).
Abnormal uterine bleeding (AUB) is a common complaint in women of reproductive age. In treatment-resistant ABU cases, it is recommended to perform an endometrial biopsy, transvaginal ultrasonography, hysteroscopy, and D&C (dilation and curettage) (4, 5).
One challenge that the surgeons face during endometrial hysteroscopy is the patient's blood loss which may be due to poor technical performance, presence of other intrauterine lesions, and loss of accumulated blood during endometrial resection (12, 13).
Evidences showed that preventive approaches by GnRH agonists and intracervical vasopressin injection may reduce the blood loss volume during surgery and systemic absorption of glycine during uterine resection by hysteroscopy (14-16).
To our knowledge, few studies were done in this area. Accordingly, in this study, the effect of oxytocin drip during hysteroscopy in patients with intrauterine lesions was evaluated on operative blood loss and fluid overload.

 

This double-blind randomized clinical trial was conducted on 54 consecutive women with abnormal uterine bleeding who were candidates for hysteroscopy for resection of fibroma or polyp (diagnosed by transvaginal ultrasonography) at Yas Hospital in 2012.
The inclusion criteria were menorrhagia and the existence of polyps and fibromas resistance to medical treatments. Patients with diabetes mellitus, severe medical background disease, pregnancy over 12 weeks, symptoms of endometriosis, and pelvic inflammatory disease and who might not tolerate sterility, were excluded.
This research was done in compliance with the Helsinki Declaration and was approved by the local ethics committee (IR.TUMS.MEDICINE.REC.1392.30.1431). All the patients signed an informed consent.
All patients were admitted one day before operation and the serum hemoglobin, hematocrit, sodium, and albumin were checked in them. Spinal anesthesia was performed for all patients. Hysteroscopy was performed by Karl-Storz instrument and the resectoscope was Karl-Storz number 12 with an Olympus camera of 8 mm diameter. Dilatation was performed up to 9 Hegar and the fluid flow rate was 300 to 450 mL per minute with distension pressure between 90 and 130 mmHg.
The subjects were randomly (by stratified block randomization) assigned to receive either oxytocin (including five Caspian tamin Pharmaceutical Company oxytocin vials containing 50 unit per mL per vial added in 500-mL ringer-lactate serum administered during surgery) or normal saline (as placebo with similar form and administration patterns) 15 minutes before the surgery with an infusion rate of 227 milli-unit per minute and the infusion stopped exactly after the termination of the operation. Then the alteration in serum hemoglobin, sodium, and hematocrit was compared between two groups (each group including 27 subjects) till 12 hours after the operation.
The entering fluid was measured but exiting fluid and central venous pressure (CVP) were not measured. The patients in the two groups were matched for confounding variables.
Data analysis was performed by SPSS software version 13 (SPSS Inc., Chicago, IL., USA). Independent-sample-T, Fisher, and Repeated-Measure ANOVA tests were used and were considered statistically significant at P-values less than 0.05.
To ensure the reliability of the questionnaire on demographic, pregnancy, and childbirth characteristics, the concurrent evaluation method was applied. Initially, the information form was completed simultaneously by the researcher and an assistant in the research environment for 10 qualified units, and then the correlation coefficients were calculated between the small variables determined by examination.
To describe the descriptive variables of the study, the central indicators and data distribution and frequency were used. Afterwards, to compare the quantitative variables with normal distribution and homogeneity of variances, an independent t-test was applied between the two groups. In cases of abnormal distribution, the Mann-Whitney U test was used. To compare and relate the quantitative and qualitative variables between the groups, the chi-square test and one-way ANOVA (Tukey) were used, respectively. In all calculations, P-value<0.05 was considered as the significance level.