Different Phenotypes of Polycystic Ovarian Disease and Their Effects on Clomiphene Resistance in Infertile Women

Ashrafi, Mahnaz; Golmohammadi, Sahar

doi:10.30699/jogcr.8.1.23

Document Type : Original Research Article

Authors

Shahid AkbarAbadi Clinical Research Development unit (SHACRDU), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran

https://doi.org/10.30699/jogcr.8.1.23

Abstract

Background & Objective: Clomiphene resistance is an important problem among women with Polycystic Ovarian Disease (PCOD) suffering from infertility. Recognition of the causes would result in better prognosis in these patients. This study was performed to determine different PCOD phenotypes and their effects on clomiphene resistance in infertile women.
Materials & Methods: In this descriptive-comparative cross-sectional study, 200 consecutive PCOD women with infertility taking clomiphene who were reffered to Akbarabadi hospital in 2017 and 2018 were enrolled. Different PCOD phenotypes and their effects on clomiphene resistance among these women were assessed.
Results: The results showed that A, B, C, and D phenotypes were observed in 79 (39.5%), 13 (6.5%), 51 (25.5%), and 57 (28.5%) patients, respectively. Sixty-one patients (30.5%) had resistance. Despite no significant difference between phenotypes (P=0.064), the most common PCOD phenotype was A (HA+OA+PCO) found in 39.2% and D (OA+PCO) was seen in 29.8% of the patients.
Conclusion: According to the results, there was no significant association between PCOD phenotypes and clomiphene resistance. Finally, A and D phenotypes were frequent types with clomiphene resistance.

Highlights

✅ According to the results, there was no significant association between PCOD phenotypes and clomiphene resistance. Finally, A and D phenotypes were frequent types with clomiphene resistance.

Keywords

Main Subjects

Obstetrics and Gynecology

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Journal of Obstetrics, Gynecology and Cancer Research

Different Phenotypes of Polycystic Ovarian Disease and Their Effects on Clomiphene Resistance in Infertile Women

References

References

Volume 8, Issue 1 - Serial Number 30
November and December 2022
Pages 23-28

Different Phenotypes of Polycystic Ovarian Disease and Their Effects on Clomiphene Resistance in Infertile Women

References

References

Volume 8, Issue 1 - Serial Number 30November and December 2022Pages 23-28

Volume 8, Issue 1 - Serial Number 30
November and December 2022
Pages 23-28