Farname Inc. in collaboration with Iranian Society of Gynecology Oncology


1 Department of Obstetrics and Gynecology, School of Medicine, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences Zanjan, Iran

2 Gynecology & Obstetric Surgeon, Zanjan University of Medical Sciences, Zanjan, Iran

3 Gynecology & Obstetric Surgeon, Zanjan University of Medical Sciences, Zanjan, Iran.


Background: Labor pain is one of the most severe pain that a woman experiences, so it’s important to research the method to reduce this pain. Paracetamol infusion is an efficient and available remedy to alleviate labor pain in an active phase is effective. This study was conducted to assess the efficacy of intravenous paracetamol injection in reducing labor pain.
Methods: In this double-blind randomized clinical trial study, the number 110 nulliparous pregnant women who were candidates for vaginal delivery were included in the study. After the onset of the active phase of labor, the control group received only 300 cc normal saline and the intervention group received 300 cc normal saline plus one gram of paracetamol. The maternal pain score, duration of the first and second stages of labor, delivery type, and Apgar score was compared between the two groups using repeated measure ANOVA.
Results: The mean age of the patients was 25.09 ± 4.2 years (18-35 years). The mean length of the first stage (2.85 vs. 3.52 hours, P = 0.001) and second stage (38.77 vs. 43.44 minutes, P = 037) in the intervention group was significantly lower than the control group. Moreover, the mean score of pain was significantly lower in the paracetamol group at all times than in the control group (P <0.05).
Conclusion: The prescription of intravenous paracetamol not only reduces pain during labor in women but also reduces the duration of different stages of labor, increases patients’ satisfaction with natural childbirth, and reduces the demand for cesarean.


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