Farname Inc. in collaboration with Iranian Society of Gynecology Oncology

Document Type : Case Reports

Authors

1 Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran

2 Departments of Pathology, Isfahan University o Medical Sciences, Isfahan, Iran

Abstract

Signet ring stromal tumor is a rare benign ovarian neoplasm, of which only about 17 cases have been reported since 1996. The signet ring appearance of this tumor may mimic a Krukenberg tumor and result in a diagnostic challenge in some cases. The previous cases occurred in adult or in old patients. We have reporteda Signet ring stromal tumor in a 13-year-old girl.

Highlights

 Signet ring stromal tumor is a rare benign ovarian neoplasm, of which only about 17 cases have been reported since 1996.

Keywords

Main Subjects

1. Ramzy I. Signet-ring stromal tumor of ovary. Cancer. 1976;38(1):166-172. [DOI:10.1002/1097-0142(197607)38:1<166::AID-CNCR2820380126>3.0.CO;2-R] [PMID]
2. SuarezA, Palacios J, Burgos E, Gamallo C. Signet-ring stromal tumor of the ovary: a histochemical, immunohistochemical and ultrastructural study. Virchows Arch A Pathol Anat Histopathol. 1993;422(4):333-6. [DOI:10.1007/BF01608344] [PMID]
3. Dickerson GR, Young RH, Scully RE. Signet-ring stromal and related tumors of the ovary. Ultrastruct Pathol. 1995;19(5):401-19. [DOI:10.3109/01913129509021913] [PMID]
4. Cashell AW, Jerome WG, Flores E. Signet ring stromal tumor of the ovary occurring in conjunction with Brenner tumor. Gynecol Oncol. 2000;77(2):323-6. [DOI:10.1006/gyno.2000.5763] [PMID]
5. Su RM, Chang KC, Chou CY. Signet-ring stromal tumor of the ovary: a case report. Int J Gynecol Cancer. 2003;13(1):90-3. [DOI:10.1136/ijgc-00009577-200301000-00017] [PMID]
6. Vang R, Bagué S, Tavassoli FA, Prat J. Signet-ring stromal tumor of the ovary: clinicopathologic analysis and comparison with Krukenberg tumor. Int J Gynecol Pathol. 2004;23(1):45-51. [DOI:10.1097/01.pgp.0000101081.35393.5f] [PMID]
7. Hardisson D, Regojo RM, Mariño-Enríquez A, Martínez-García M. Signet-ring stromal tumor of the ovary: report of a case and review of the literature. Pathol Oncol Res. 2008;14(3):333-6. [DOI:10.1007/s12253-008-9080-6] [PMID]
8. Matsumoto M, Hayashi Y, Ohtsuki Y, Ikegami N, Toi M, Iguchi M, Hiroi M. Signet-ring stromal tumor of the ovary: an immunohistochemical and ultrastructural study with a review of the literature. Med Mol Morphol. 2008;41(3):165-70. [DOI:10.1007/s00795-008-0404-0] [PMID]
9. Forde GK, Harrison C, Doss BJ, Forde AE, Carlson JW. Bilateral and multinodular signet-ring stromal tumor of the ovary. Obstet Gynecol. 2010;116 Suppl 2:556-8. [DOI:10.1097/AOG.0b013e3181e9b410] [PMID]
10. Sükür YE, Ozmen B, Atabekoğlu CS, Sönmezer M, Ortaç F. Signet-ring stromal tumor of the ovary: an extremely rare neoplasm. J Turk Ger Gynecol Assoc. 2011;12(1):59-60. [DOI:10.5152/jtgga.2011.14] [PMID] [PMCID]
11. McGregor SM, Schoolmeester JK, Lastra RR. Collision Signet-Ring Stromal Tumor and Steroid Cell Tumor of the Ovary: Report of the First Case. Int J Gynecol Pathol. 2017;36(3):261-4. [DOI:10.1097/PGP.0000000000000321] [PMID]
12. Kopczynski J, Kowalik A, Chlopek M. Oncogenic activation of the Wnt/[beta]-catenin signalling pathway in signet ring stromal cell tumor of the ovary. Appl Immunohistochem Mol Morphol. 2016;24(5):e28-e33. [DOI:10.1097/PAI.0000000000000271] [PMID] [PMCID]
13. Chen PH, Hui P, Buza N. Bilateral Signet-ring Stromal Tumor of the Ovary: A Case Report with Next-generation Sequencing Analysis and FOXL2 Mutation Testing. Int J Gynecol Pathol. 2020;39(2):193-8. [DOI:10.1097/PGP.0000000000000579] [PMID]
14. Tsai TY, Wu PS. Collision of sclerosing stromal tumor and signet-ring stromal tumor of the ovary: Report of the first case. Kaohsiung J Med Sci. 2020;36(2):143-4. [DOI:10.1002/kjm2.12135] [PMID]