Farname Inc. in collaboration with Iranian Society of Gynecology Oncology


1 Reproductive Health Research Center, Department of Obstetrics & Gynecology, Al-zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

2 Reproductive Health Research Center , Department of Obstetrics & Gynecology, Al-zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

3 Guilan University of Medical Sciences, Rasht, Iran

4 Eye Research Center, Department of Eye, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

5 Reproductive Health Research Center, Al-zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran

6 Vice-Chancellorship of Research and Technology, Guilan University of Medical Science, Rasht


Background and objective:   Most pain relief methods are associated with some side effects and limitations. Magnesium sulfate, due to its osmotic properties and absorption of cervical water (moisture) can shorten labor duration and decrease labor pain via improving effacement and cervical edema. The aim of our study was to evaluate the effect of intravaginal magnesium sulfate on pain severity and duration of the first and second stages of labor.
METHODS: In this double-blind randomized clinical trial study, 70 nulliparous women were allocated into two groups after the beginning of the active phase of labor. In the group 1, 10 ccs of magnesium sulfate 50% was poured on the whole cervix during the vaginal examination. In the group 2, a placebo (sterile water) in the similar way and amount was used. Then the two groups were compared in variables of demographic, obstetrics, clinical, pain severity, and duration of the first and second stages of labor, maternal and neonatal outcomes.
RESULTS: In different dilatations, pain severity in the group 1 was significantly lower (p=0.0001). The duration of the first and second stages of labor was shorter in the group 1 (p=0.0001). The two groups were similar in neonatal outcomes, drug side effects, and treatment satisfaction(p>0.05).
CONCLUSION: Intravaginal magnesium sulfate improves the condition of the cervix, reduces the duration and the severity of labor pain, and has no medical or neonatal side effects.


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