Iranian Society of Gynecology Oncology


1 Department of Obstetrics and Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2 Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

3 Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


Polycystic ovary syndrome (PCOS) is a hormonal disorder that affecting women of reproductive age. Several genetic and environmental factors are contributed to the progression of PCOS. Experimental discoveries have begun to evaluate the mechanisms involved in PCOS. There is a mechanistic link between long non-coding RNAs (lncRNAs) and the pathogenesis of PCOS. LncRNAs are a class of transcripts that mediate the process of gene expressions at the level of transcription and post-transcription. It has been found that lncRNA MALAT-1 presents a vital role in regulating PCOS. MALAT-1 as a competing endogenous RNA (ceRNA) can suppress microRNAs (miRNAs) and decrease granulosa cell proliferation, apoptosis, and pathogenesis. In the present article, we summarize the functions of the lncRNA MALAT-1/miRNA axes in PCOS.


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