Iranian Society of Gynecology Oncology

Document Type : Original Research Article


1 Department of Obstetrics and Gynecology, College of Medicine, Al-Anbar University, Ramadi, Iraq

2 medical college Mustansiriyah University, Iraq


Background: The endometrial receptivity is controlled by biomarkers, hormones, growth factors, and cytokines interaction, disorders in these biomarkers will affect endometrial receptivity and this may possibly have correlated with unexplained infertility, the aim of study is to assess the correlation between integrin Alpha v Beta3 expression, endometrial thickness and sub- endometrial blood flow resistance index in unexplained Infertility. Methods: case control study includes two group of woman, infertile women with unexplained infertility considered as a case group and fertile control group. The study carried out on Kamal – Al-Samurai fertility center in the period from October 2020 - September 2021. Six days after detecting urinary LH surge, asked to come to two do dimension 2D transvaginal ultrasound to assess endometrial thickness and sub-endometrial blood flow color Doppler resistance index and endometrial samples was taken and examined immunohistochemically to detect Alpha v Beta3 integrin. Result: total women enrolled in the study were 80. The endometrial thickness was lower and resistance index was higher in case group (p < /i> < 0.001). The expression of integrin Alpha v Beta3 in infertile group was significantly low ((p < /i> < 0.001) with significant positive correlation between integrin score and endometrial thickness (r= -0.708 & p < 0.001) and significant negative correlation between integrin score and sub-endometrial resistance index (r= -0.786 & p <0.001). Conclusion: Alpha v beta 3 integrin expressions and endometrial thickness are reduced significantly in mid-luteal phase while the sub endometrial blood flow color Doppler resistant index significantly increased, and using them together can possibly be used as a diagnostic predictor of unexplained infertility.


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