Iranian Society of Gynecology Oncology


1 Department of Obstetrics and Gynecology, School of Medicine, Zanjan university Medical Sciences, Zanjan, Iran

2 Department of Operating Room and Anesthesiology, School of Nursing and Midwifery, Zanjan University Medical Sciences, Zanjan, Iran


Background: Types of major surgeries are associated with postoperative pain sometimes during the days after surgery. These pains mainly lead to the use of various analgesics and ultimately patient dissatisfaction. In the present study, we evaluated the effect of gabapentin at doses of 600 and 1200 mg in relieving pain due to cesarean section.
Methods: In this randomized clinical trial patients were randomly divided into three equal-size groups (25 patients in each group) through balanced block randomization. The first group was given 600 mg of gabapentin the second group was given 1200 mg of gabapentin one hour before surgery and the control group received a placebo. The pain intensity, occurring nausea/vomiting and drowsiness, as well as needing postoperative analgesics were assessed initially and at 2, 6, and 12 hours after surgery. The occurrence of nausea and drowsiness between groups was compared using chi-square and exact fisher teat.
Results: The mean (SD) age of patients in the gabapentin 1200 mg, gabapentin 800 mg, and placebo groups were 26.32±6.15, 27.43±6.38, and 26.59±5.88, respectively (P=0.34). Pain intensity and also the rate of analgesic consumption at the different time points during the first 12 hours of surgery were significantly lower in the receiving gabapentin groups compared to the placebo group (P<0.05). Comparing the prevalence rates of nausea and vomiting and also drowsiness as the drug-related side effects don’t show a significant difference across the three groups at the different investigated time points (P>0.05).
Conclusion: Gabapentin with a minimum therapeutic dose can successfully reduce postoperative pain intensity and also needs analgesics use after cesarean section.  


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