Iranian Society of Gynecology Oncology

Document Type : Original Research Article

Authors

1 Department of Obstetrics and Ggynecology, Non-profit Joint-Stock Company Semey Medical University, Semey, Republic of the Kazakhstan

2 College of Medical Technology, Medical Lab Techniques, Al-Farahidi University, Baghdad, Iraq

3 Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Iraq

4 College of Media, The Islamic University of Najaf, Najaf, Iraq

5 Mazaya University College, Nasiriyah, Iraq

6 College of Nursing, National University of Science and Technology, Dhi Qar, Iraq

7 Department of Radiology and Sonar Techniques, AlNoor University College, Nineveh, Iraq

Abstract

Background & Objective: Preeclampsia is related to numerous maternal and fetal complications, like intrauterine increase restriction, preterm delivery, and a raised danger of baby death. In order to determine the predictive amount of uterine artery Doppler sonography indices for neonatal complications in pregnant patients with preeclampsia, the present study was conducted.
Materials & Methods: In 2020, in Alwiyah Hospital for Obstetrics and Gynecology, Al-Jadiriah Private Hospital, Al-Karama Teaching Hospital, and Yarmouk Teaching Hospital in Baghdad, 87 pregnant women with preeclampsia and 160 healthy pregnant women participated in the present prospective study. The Doppler signal of the uterine arteries was evaluated during a supine abdominal Doppler ultrasound examination between 26 and 36 weeks of pregnancy. The survey form was updated with information about the birth of the children following the termination of the pregnancy. The data were evaluated using SPSS software (version 19) and independent t, Mann-Whitney, and chi-square tests.
Results: The mean uterine artery pulsatility index of mothers with preeclampsia had the greatest sensitivity, specificity, and positive predictive amount of predicting a baby's low birth weight at 54.8%, 87.3%, and 91.6%, respectively. In addition, the sensitivity, specificity, and positive predictive amount of the mean uterine artery resistance index for predicting a baby's low birth weight were 65.2%, 96.4%, and 95.4%, respectively.
Conclusion: Although uterine artery indices in Doppler ultrasound do not have a high sensitivity for predicting neonatal complications, abnormal indices can predict low birth weight with high confidence.

Highlights

 Although uterine artery indices in Doppler ultrasound do not have a high sensitivity for predicting neonatal complications, abnormal indices can predict low birth weight with high confidence.

Keywords

Main Subjects

1. Hannaford KE, Tuuli M, Goetzinger KR, Odibo L, Cahill AG, Macones G, et al. First‐Trimester 3‐Dimensional Power Doppler Placental Vascularization Indices From the Whole Placenta Versus the Placental Bed to Predict Preeclampsia: Does Pregnancy‐Associated Plasma Protein A or Uterine Artery Doppler Sonography Help? J Ultrasound Med. 2015;34(6):965-70. [DOI:10.7863/ultra.34.6.965] [PMID]
2. Borna S, Ghaemi M, Golshahi F, Shariat M, Shirazi M, Sahebdel B. Comparing Fetal Arteries' Doppler Ultrasound Pulsatility Indexes Premature Preterm Rupture of Membrane in Admission and Pregnancy Termination. J Obstet Gynecol Cancer Res. 2020;5(4):159-66. [DOI:10.30699/jogcr.5.4.159]
3. Tabasum S, Sher Z, Mushtaq S, Mukhtar A, Sharif S, Rasheed F. Comparison of Umbilical Artery Doppler and Amniotic Fluid Index in Prediction of Obstetrical and Perinatal Outcome≥ 34 Weeks of Gestation. J Soc Obstet Gynecol Pak. 2022;12(3):179-82.
4. Sharifzadeh Mahalati F, Moeini Chaghervand M, Hashemi Dizaji S, Chamani M. Evaluation of the Relationship Between Prenatal Doppler Findings and Hematological Profile in Neonates with Intrauterine Growth Restriction at 32 to 36 Weeks of Gestation. J Obstet Gynecol Cancer Res. 2019;4(2):81-5. [DOI:10.30699/jogcr.4.2.81]
5. Liu S, Sun Y, Luo N. Doppler Ultrasound Imaging Combined with Fetal Heart Detection in Predicting Fetal Distress in Pregnancy-Induced Hypertension under the Guidance of Artificial Intelligence Algorithm. J Healthc Eng. 2021;2021. [DOI:10.1155/2021/4405189] [PMID] [PMCID]
6. Cui H, Yu L, Li H, Wang H, Liang W, Wang H, et al. Evaluation of placental growth potential and placental bed perfusion by 3D ultrasound for early second-trimester prediction of preeclampsia. J Assist Reprod Genet. 2022;39(7):1545-54. [DOI:10.1007/s10815-022-02530-z] [PMID]
7. Cahill LS, Stortz G, Chandran AR, Milligan N, Shinar S, Whitehead CL, et al. Wave reflections in the umbilical artery measured by Doppler ultrasound as a novel predictor of placental pathology. EBioMedicine. 2021;67:103326. [DOI:10.1016/j.ebiom.2021.103326] [PMID] [PMCID]
8. Mohammed O, Magdy A, Askalany A, Salem S, Abdel-Rasheed M, Ghobary H, et al. Role of Maternal Uterine Artery Doppler Versus Serum β-hCG During the First Trimester in the Prediction of Preeclampsia and IUGR. J Diagn Med Sonogr. 2022;38(2):111-8. [DOI:10.1177/87564793211051986]
9. Sharma M, Sharma G, Verma A. Umbilical Artery Systolic/Diastolic Ratio and Amniotic Fluid Index in Prediction of Adverse Perinatal Outcome in Term Pregnancies. Int j Appl Basic Med Res. 2022;12(2):76-81. [DOI:10.4103/ijabmr.ijabmr_452_21] [PMID] [PMCID]
10. Mansour Ghanaei M, Amir Afzali S, Morady A, Mansour Ghanaie R, Asghari Ghalebin SM, Rafiei E, et al. Intrauterine Growth Restriction with and without Pre-Eclampsia: Pregnancy Outcome and Placental Findings. J Obstet Gynecol Cancer Res. 2022;7(3):177-85. [DOI:10.30699/jogcr.7.3.177]
11. Zhou S, Guo H, Feng D, Han X, Liu H, Li M. Middle Cerebral Artery-to-Uterine Artery Pulsatility Index Ratio and Cerebroplacental Ratio Independently Predict Adverse Perinatal Outcomes in Pregnancies at Term. Ultrasound Med Biol. 2021;47(10):2903-9. [DOI:10.1016/j.ultrasmedbio.2021.06.015] [PMID]
12. Salman AM, Al-Jiboori MA, Khaleel HQ, Adnan E. The Role of The Doppler Study (Umbilical, Middle, Cerebral Arteries and Ductus Venosus) to Predict General Adverse Pregnancy Outcomes in Patients With Hypertensive Diseases in The Third Trimester. Diyal J Med. 2021;21(2):10-21. [DOI:10.26505/DJM.21025751023]
13. Patwa PA, Mishra GV, Dhande RP, Singh RK, Singh S. Utility of uterine artery doppler indices for prediction of preeclampsia: A narrative review with systematic analysis. J Datta Meghe Inst Med Sci Univ. 2022;17(3):757. [DOI:10.4103/jdmimsu.jdmimsu_413_21]
14. Moawad EMI, Tammam ASF, Mosaad MM, Sayed HME, Atef A. Evaluating the predictive value of fetal Doppler indices and neonatal outcome in late-onset preeclampsia with severe features: a cross-sectional study in a resource-limited setting. BMC Pregnancy and Childbirth. 2022;22(1):1-12. [DOI:10.1186/s12884-022-04704-0] [PMID] [PMCID]
15. Abedini F, Eshraghi N, Mohammadian Amiri M, Danaei M. Assessment of Communication AFI and Uterocervical Angle with Pregnancy Duration in Patients with Pretem Premature Rupture of Membranes 24-34 Weeks. J Obstet Gynecol Cancer Res. 2022;7(6):489-96. [DOI:10.30699/jogcr.7.6.489]
16. Adekanmi AJ, Roberts A, Morhason-Bello IO, Adeyinka AO. Utilization of Uterine and Umbilical Artery Doppler in the Second and Third Trimesters to Predict Adverse Pregnancy Outcomes: A Nigerian Experience. Women's Health Rep. 2022;3(1):256-66. [DOI:10.1089/whr.2021.0058] [PMID] [PMCID]
17. Moradi B, Sadrarhami S, Banihashemian M, Gity M, Tahmasebpour A-R, Kazemi MA. Ultrasonography and Magnetic Resonance Imaging in a Fetus with Sacrococcygeal Teratoma: A Case Report. J Obstet Gynecol Cancer Res. 2018;3(4):165-8. [DOI:10.30699/jogcr.3.4.26]
18. Ali AE-S, Elsayed YAE, Saad HMD, Elkataway AM. Prediction and Prevention of Pre-eclampsia by Measuring Mean Platelet Volume and Uterine Artery Doppler Indices in High-Risk Pregnant Women. Egypt J Hosp Med. 2022;88(1):2319-24. [DOI:10.21608/ejhm.2022.235955]
19. Pérez CJM, Leaños AGN, Juárez RIC, Lechuga MGB, Salas II, Miranda AL. Soluble Endoglin and Uterine Artery Flow Doppler Ultrasonography as Markers of Progression to Preeclampsia in Women with Gestational Hypertension. Gynecol Obstet Invest. 2021;86(5):445-53. [DOI:10.1159/000519371] [PMID]
20. Besimoglu B, Uyan Hendem D, Atalay A, Göncü Ayhan Ş, Sınacı S, Tanaçan A, et al. Combination of Doppler measurements with amniotic fluid volume for the prediction of perinatal outcomes in fetal growth restriction. Int J Gynaecol Obstet. 2022. [DOI:10.1002/ijgo.14431] [PMID]
21. Ashwal E, Ali-Gami J, Aviram A, Ronzoni S, Mei-Dan E, Kingdom J, et al. Contribution of Second Trimester Sonographic Placental Morphology to Uterine Artery Doppler in the Prediction of Placenta-Mediated Pregnancy Complications. J Clin Med. 2022;11(22):6759. [DOI:10.3390/jcm11226759] [PMID] [PMCID]
22. Bolz N, Kalache KD, Fotopoulou C, Proquitte H, Slowinski T, Hartung JP, et al. Value of Doppler sonography near term: can umbilical and uterine artery indices in low-risk pregnancies predict perinatal outcome? J Perinat Med. 2013;41(2):165-70. [DOI:10.1515/jpm-2012-0042] [PMID]
23. Axt-Fliedner R, Schwarze A, Nelles I, Altgassen C, Friedrich M, Schmidt W, et al. The value of uterine artery Doppler ultrasound in the prediction of severe complications in a risk population. Arch Gynecol Obstet. 2005;271(1):53-8. [DOI:10.1007/s00404-004-0648-4] [PMID]
24. Cnossen JS, Morris RK, Ter Riet G, Mol BW, Van Der Post JA, Coomarasamy A, et al. Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis. CMAJ. 2008;178(6):701-11. [DOI:10.1503/cmaj.070430] [PMID] [PMCID]
25. Kuc S, Wortelboer EJ, van Rijn BB, Franx A, Visser GH, Schielen PC. Evaluation of 7 serum biomarkers and uterine artery Doppler ultrasound for first-trimester prediction of preeclampsia: a systematic review. Obstet Gynecol Surv. 2011;66(4):225-39. [DOI:10.1097/OGX.0b013e3182227027] [PMID]
26. Harrington K, Carpenter R, Goldfrad C, Campbell S. Transvaginal Doppler ultrasound of the uteroplacental circulation in the early prediction of pre‐eclampsia and intrauterine growth retardation. Int J Gynaecol Obstet Gynecol. 1997;104(6):674-81. [DOI:10.1111/j.1471-0528.1997.tb11977.x] [PMID]
27. Schwarze A, Nelles I, Krapp M, Friedrich M, Schmidt W, Diedrich K, et al. Doppler ultrasound of the uterine artery in the prediction of severe complications during low-risk pregnancies. Arch Gynecol Obstet. 2005;271(1):46-52. [DOI:10.1007/s00404-004-0646-6] [PMID]
28. Harrington K, Fayyad A, Thakur V, Aquilina J. The value of uterine artery Doppler in the prediction of uteroplacental complications in multiparous women. Ultrasound Obstet Gynecol. 2004;23(1):50-5. [DOI:10.1002/uog.932] [PMID]
29. Shahinaj R, Manoku N, Kroi E, Tasha I. The value of the middle cerebral to umbilical artery Doppler ratio in the prediction of neonatal outcome in patient with preeclampsia and gestational hypertension. J Perinat Med. 2010;4(2):17.
30. Ohkuchi A, Minakami H, Sato I, Mori H, Nakano T, Tateno M. Predicting the risk of pre‐eclampsia and a small‐for‐gestational‐age infant by quantitative assessment of the diastolic notch in uterine artery flow velocity waveforms in unselected women. Ultrasound Obstet Gynecol. 2000;16(2):171-8. [DOI:10.1046/j.1469-0705.2000.00192.x] [PMID]
31. Arias F. Fetus-placenta-newborn: accuracy of the middle-cerebral-to-umbilical-artery resistance index ratio in the prediction of neonatal outcome in patients at high risk for fetal and neonatal complications. Am J Obstet Gynecol. 1994;171(6):1541-5. [DOI:10.1016/0002-9378(94)90398-0] [PMID]
32. Fardiazar Z, Atashkhouei S, Yosefzad Y, Goldust M, Torab R. Comparison of fetal middle cerebral arteries, umbilical and uterin artery color Doppler ultrasound with blood gas analysis in pregnancy complicated by IUGR. Iran J Reprod Med. 2013;11(1):47.
33. Sharbaf FR, Movahed F, Pirjani R, Teimoory N, Shariat M, Farahani Z. Comparison of fetal middle cerebral artery versus umbilical artery color Doppler ultrasound for predicting neonatal outcome in complicated pregnancies with fetal growth restriction. Biomed Res Ther. 2018;5(5):2296-304. [DOI:10.15419/bmrat.v5i5.443]
34. Yalti S, Oral Ö, Gürbüz B, Özden S, Atar F. Ratio of middle cerebral to umbilical artery blood velocity in preeclamptic & hypertensive women in the prediction of poor perinatal outcome. Indian J Med Res. 2004;120(1):44.
35. Melchiorre K, Leslie K, Prefumo F, Bhide A, Thilaganathan B. First‐trimester uterine artery Doppler indices in the prediction of small‐for‐gestational age pregnancy and intrauterine growth restriction. Ultrasound Obstet Gynecol. 2009;33(5):524-9. [DOI:10.1002/uog.6368] [PMID]