Successful Management of Severe Early-Onset Fetal Hemolytic Anemia Due to Anti-Rh17 Alloimmunization: A Case Report

Ghalandarpoor-Attar, Seyedeh Noushin; Rahimi-Sharbaf, Fatemeh; Ghalandarpoor-Attar, Seyedeh Mojgan

doi:10.30699/jogcr.8.5.533

Document Type : Case Report Article

Authors

¹ Department of Obstetrics and Gynecology, Baqyiatallah Hospital, Baqyiatallah University of Medical Sciences, Tehran, Iran

² Department of Feto-Maternal, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran

³ Department of Obstetrics and Gynecology, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran

https://doi.org/10.30699/jogcr.8.5.533

Abstract

As widespread prophylaxis with anti-D Antibodies has dramatically diminished anti-D-associated hemolytic disease of the newborn (HDN), other antibodies-associated HDN has become relatively more significant. Two genes encode Rh proteins: the RhD gene coding for the D and the Rh CcEe gene coding for Cc Ee Antigens. D is a rare Rh phenotype in which RBCs lack Cc/Ee antigens while D antigen is strongly expressed. Anti R17 antibodies are important monomorphic antibodies acting against all previously mentioned antigens. It can pass through the placenta as a G immunoglobulin, leading to fetal or neonatal hemolysis. Here, we reported an immunized pregnant female with D- - phenotype and a history of intrauterine fetal death who had high titer of anti-Rh17 antibodies in her subsequent pregnancy. We would discuss our management strategy which led to good perinatal outcomes. To the best of our knowledge, this is the second case of HDN reported in English written literature in Iran.

Keywords

Main Subjects

Maternal Fetal Medicine

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Journal of Obstetrics, Gynecology and Cancer Research

Successful Management of Severe Early-Onset Fetal Hemolytic Anemia Due to Anti-Rh17 Alloimmunization: A Case Report

References

References

Volume 8, Issue 5 - Serial Number 34
September and October 2023
Pages 533-537

Successful Management of Severe Early-Onset Fetal Hemolytic Anemia Due to Anti-Rh17 Alloimmunization: A Case Report

References

References

Volume 8, Issue 5 - Serial Number 34September and October 2023Pages 533-537

Volume 8, Issue 5 - Serial Number 34
September and October 2023
Pages 533-537