Iranian Society of Gynecology Oncology

Document Type : Original Research Article


1 M.B.Ch.B, F.I.B.OG

2 M.B.Ch.B. C.A.B.O.G, F.I.C.O.G, Consultant Obstetrician and Gynecologist

3 3. Consultant Ob/Gyn/lnfertility, Arab and Iraqi Board in obstetrics and gynecology 2000, Fellowship of Infertility and Reproductive Medicine 2017_2019, Director of Alzaitoon Specialized Fertility Center, President of IFS


Background: Melatonin play a role in pubertal development and reproductive function through the Hypothalamus-hypophysis-gonadal axis. In addition, melatonin production decreases with age, so that indolamine could be an anti-ageing agent. To assess Intra follicular melatonin level's role in ovarian reserve and the IVF cycle outcomes.

Patients and method: A prospective cross-sectional study was conducted from April 2022 to April 2023. Patients on a mini-long agonist, short agonist, and antagonist protocols were enrolled in the current study. Using ultrasound, the follicle development was observed from the stimulation day until the hCG day (done every 2 or 3 days).

Results: Melatonin were positively correlated with oocyte retrieved (r=0.705, P<0.001), number of fertilized oocyte (r=0.68, P<0.001), number of zygotes cleaved (r=0.660, P<0.001), high quality embryos (r=0.591, P<0.001), embryos for transplantation (r=0.604, P<0.001), percent of high quality embryos (r=0.58, P<0.001), and with percent of blastocyst rate.

Conclusion: Melatonin mean levels in follicular fluid were significantly decreased in poor response than in standard and high response. The follicular fluid melatonin levels were associated with each oocyte quantity and quality and can expect ICSI consequences and act as highly important biochemical indicators of ovarian reserve.


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