Evaluation of the Relationship Between Short Femur Length and Preeclampsia

Jafari Fard, Azam; Sadeghpour, Sonia; Bahadori, Fatemeh; Rasouli, Javad

doi:10.30699/jogcr.9.1.36

Document Type : Original Research Article

Authors

¹ Department of Obstetrics and Gynecology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

² Department of Obstetrics and Gynecology, Reproductive Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran

³ Department of Epidemiology and Biostatistics, School of Medicine, Urmia University of Medical Science, Urmia, Iran

https://doi.org/10.30699/jogcr.9.1.36

Abstract

Background & Objective: Preeclampsia is a perinatal and maternal morbidity and mortality-related pregnancy disease. A diagnostic challenge is frequently presented by the finding of a small femur length, especially below the fifth percentile. When the ultrasound was performed, it can be related to fetal growth restriction. This study sought to determine how short femur diaphysis length (FDL) during 32–37 weeks of gestation affected preeclampsia.
Materials & Methods: Between February 2021 and February 2022, pregnant women who received a regular abnormality scan at the Shahid Motahari University Hospital in Urmia, Iran, between 32 and 37 weeks of gestation were included in the study. As part of the abnormality scan, fetal biometry and uterine artery Doppler ultrasound were evaluated, and the mean pulsatility index of the two uterine arteries was noted. From our database system, we gathered information on maternal obstetric features such as ethnicity, age, weight, parity, smoking, and medical history including hypertension and diabetes mellitus.
Results: The present study's findings showed that preeclampsia, maternal age, and the number of prior pregnancies were all connected with multivariate analysis of the fetal femoral length percentile. Additionally, the 50th percentile femoral's sensitivity and specificity for the diagnosis of preeclampsia were 96.88 and 81.88, respectively.
Conclusion: According to our findings, there is a substantial association between PE and short FLduring 32–37 weeks of gestation.

Highlights

✅ According to our findings, there is a substantial association between PE and short FLduring 32–37 weeks of gestation.

Keywords

Main Subjects

Maternal Fetal Medicine

References

1. Fondjo LA, Boamah VE, Fierti A, Gyesi D, Owiredu E-W. Knowledge of preeclampsia and its associated factors among pregnant women: a possible link to reduce related adverse outcomes. BMC Pregnancy Childbirth. 2019;19(1):1-7. [DOI:10.1186/s12884-019-2623-x] [PMID] [PMCID]

2. Keshavarz E, Sadeghian A, Ganjalikhan Hakemi A, Talei Khtibi F. Prediction of Pre-Eclampsia Development by Placenta Location: A Simple Predictor. J Obstet Gynaecol Cancer Res. 2022;2(4):1-5. [DOI:10.5812/jogcr.11945]

3. Fox R, Kitt J, Leeson P, Aye CYL, Lewandowski AJ. Preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring. J Clin Med. 2019;8(10):1625. [DOI:10.3390/jcm8101625] [PMID] [PMCID]

4. Rahayu KD, Sigit R, Agata D, Pambudi A, Istiqomah N, editors. Automatic Gestational Age Estimation by Femur Length Using Integral Projection from Fetal Ultrasonography. 2018 International Seminar on Application for Technology of Information and Communication; 2018.

5. Moawad EMI, Tammam ASF, Mosaad MM, Sayed HME, Atef A. Evaluating the predictive value of fetal Doppler indices and neonatal outcome in late-onset preeclampsia with severe features: a cross-sectional study in a resource-limited setting. BMC Pregnancy and Childbirth. 2022;22(1):377. [DOI:10.1186/s12884-022-04704-0] [PMID] [PMCID]

6. Ghulmiyyah L, Sibai B. Maternal Mortality From Preeclampsia/Eclampsia. Semin Perinatol. 2012;36(1):56-9. [DOI:10.1053/j.semperi.2011.09.011] [PMID]

7. Hutcheon JA, Lisonkova S, Joseph KS. Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy. Best Pract Res Clin Obstet Gynaecol. 2011;25(4):391-403. [DOI:10.1016/j.bpobgyn.2011.01.006] [PMID]

8. Huppertz B. Special Issue "Molecular and Cellular Mechanisms of Preeclampsia". 2020. p. 4801. [DOI:10.3390/ijms21134801] [PMID] [PMCID]

9. Weissgerber TL, Milic NM, Milin-Lazovic JS, Garovic VD. Impaired Flow-Mediated Dilation Before, During, and After Preeclampsia. Hypertension. 2016;67(2):415-23. [DOI:10.1161/HYPERTENSIONAHA.115.06554] [PMID] [PMCID]

10. D'Ambrosio V, Vena F, Marchetti C, Di Mascio D, Perrone S, Boccherini C, et al. Midtrimester isolated short femur and perinatal outcomes: A systematic review and meta-analysis. Acta Obstet Gynecol Scand. 2019;98(1):11-7. [DOI:10.1111/aogs.13470] [PMID]

11. Ventura W, Huaman J, Nazario CE, Ingar J, Huertas E, Antonio Limay O. Perinatal outcomes after sonographic detection of isolated short femur in the second trimester. Clin Ultrasound. 2012;40(2):63-7. [DOI:10.1002/jcu.20889] [PMID]

12. Todros T, Massarenti I, Gaglioti P, Biolcati M, Botta G, De Felice C. Fetal short femur length in the second trimester and the outcome of pregnancy. BJOG. 2004;111(1):83-5. [DOI:10.1046/j.1471-0528.2003.00015.x] [PMID]

13. Friebe-Hoffmann U, Dobravsky L, Friedl TWP, Janni W, Knippel AJ, Siegmann HJ, Kozlowski P. The femur too short? 1373 fetuses with short femur during second-trimester screening. Arch Gynecol Obstet. 2022;306(4):1037-44. [DOI:10.1007/s00404-021-06394-z] [PMID] [PMCID]

14. Macdonald-Wallis C, Lawlor DA, Heron J, Fraser A, Nelson SM, Tilling K. Relationships of risk factors for pre-eclampsia with patterns of occurrence of isolated gestational proteinuria during normal term pregnancy. PLoS One. 2011;6(7):e22115. [DOI:10.1371/journal.pone.0022115] [PMID] [PMCID]

15. Cunningham F, Leveno K, Bloom S, Hauth J, Rouse D, Spong C. Williams's obstetrics. 23rd ed. New York: McGraw-Hill; 2010.

16. Bahadoran P, Zendehdel M, Movahedian A, Zahraee RH. The relationship between serum zinc level and preeclampsia. Iran J Nurs Midwifery Res. 2010;15(3):120-4.

17. Shahidifar s, Sharifnia H, Taghipoor B, Hekmat Afshar M, Motevalli R, khalili Y, Mazraie F. Association between seasonal patterns and preeclampsia. Iran J Obstet Gynecol Infertil. 2014;17(125):8-14.

18. Sheen J-J, Huang Y, Andrikopoulou M, Wright JD, Goffman D, D'Alton ME, Friedman AM. Maternal age and preeclampsia outcomes during delivery hospitalizations. Am J Perinatol. 2020;37(01):044-52. [DOI:10.1055/s-0039-1694794] [PMID]

19. Kashanian M, Mohammadi A, Baradaran HR. Evaluation of Some of the risk factors for preeclampsia. Razi J Med Sci. 2008;15:131-6.

20. Bromley B, Brown DL, Benacerraf BR. Short femur length associated with severe intrauterine growth retardation. Prenat Diagn. 1993;13(6):449-52. [DOI:10.1002/pd.1970130605] [PMID]

21. Mailath-Pokorny M, Polterauer S, Worda K, Springer S, Bettelheim D. Isolated short fetal femur length in the second trimester and the association with adverse perinatal outcome: experiences from a tertiary referral center. PLoS One. 2015;10(6):e0128820. [DOI:10.1371/journal.pone.0128820] [PMID] [PMCID]

22. Morales-Roselló J, Peralta Llorens N. Outcome of Fetuses with Diagnosis of Isolated Short Femur in the Second Half of Pregnancy. Obstet Gynecol. 2012;2012:268218. [DOI:10.5402/2012/268218] [PMID] [PMCID]

Journal of Obstetrics, Gynecology and Cancer Research

Evaluation of the Relationship Between Short Femur Length and Preeclampsia

References

References

Volume 9, Issue 1 - Serial Number 36
January and February 2024
Pages 36-44

Evaluation of the Relationship Between Short Femur Length and Preeclampsia

References

References

Volume 9, Issue 1 - Serial Number 36January and February 2024Pages 36-44

Volume 9, Issue 1 - Serial Number 36
January and February 2024
Pages 36-44