Document Type : Original Research Article
Authors
1 Ibn El Jazzar Faculty of Medicine, University of Sousse, Tunisia
2 LR21ES03, Oncogenesis and Tumor progression, Faculty of Medicine of Sousse, University of Sousse, Tunisia
3 Anatomic and Cytopathologic Laboratory, Sahloul University Hospital, Sousse, Tunisia
4 Department of Pharmacology, College of Medicine, University of Thi-Qar, Thi-Qar 64001, Iraq
Abstract
Background & Objective: Polycystic ovary syndrome (PCOS) is a common disease in women of childbearing age. The inflammation has participated in the metabolic disorders and irregular menstruation associated with this disease. This study was carried out to correlate between the disturbance of pro-inflammatory markers resistin, adiponectin and metabolic parameters in women with PCOS.
Materials & Methods: Fasting blood samples were collected from 100 PCO married infertile women (23.30±4.659 years) attending Bint AL-Hoda and Al-Shatra hospitals in Thi- Qar province - Iraq, in addition to 50 healthy age matched (23.84±4.804 years) control, through the period from June 2022 to December 2022.
Results: The BMI of PCO patients (27.22±7.20) was significantly (<0.001) more that BMI of the healthy control (22.84±4.63). PCO patients showed significantly elevation of serum levels of resistin (470.00±114.00 vs 350.00±90.60 ng/l, P<0.01 (and significant decline of adiponectin (5.13±1.22 vs 11.00±1.40 mg/l, P<0.001) in comparison with healthy control. PCO patients also showed significant elevation of the serum glucose (P<0.01), total cholesterol (P<0.05), triglycerides (P<0.001) and LDL (P<0.001). However, serum HDL level was insignificant declined and VLDL was insignificantly elevated in PCO group compared with healthy control group.
Conclusion: Adiponectin and resistin represented part of the pathophysiology of PCO, and may serve as beneficial indicator in the diagnosis and treatment.
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