Endometrial carcinoma (EC) is one of commonest ten cancers, and represents fourth most widespread malignancy in females, it mainly happen in postmenopausal women. Endometrial cancer creates from the endometrium and is classified, depend on the development mechanism, into kinds 1 and 2, which are responsive and non-responsive to estrogen, respectively and have significantly diverse gene expression profiles. This study was carried out in Laboratories of the College of Science/ Department of Biology and in a local lab during the period between December 2021 to August 2022. The study of PCR was used to detection HOXA11 expression .We aimed to describe the histological changes of tumors malignant and benign and normal tissues of the endometrial and determine the relationships between HOXA11 expression with the histopathological variables involving, stage, grade, muscle and lymph nodes invasiveness and histological types. results shows the values of HOXA11 expression and a significant difference (P-value>0.001) between patients with endometrial cancer and control group, these results regarding the values means of HOXA11 expression a significant difference (P-value=0.021) between patients with benign tumor and the control and the values means of HOXA11 expression a significantly difference (P-value >0.001) between patients with endometrial cancer and benign tumor.