Iranian Society of Gynecology Oncology

Document Type : Original Research Article

Authors

1 Tehran University of Medical Sciences

2 Department of Obstetrics & Gynecology, Arash Women Hospital, Tehran University of Medical Sciences, Tehran, Iran2. Research Development Center, Arash Women Hospital, Tehran University of Medical Sciences, Tehran, Iran

3 Gynaecology Oncology ward, Vali-e-Asr Hospital Tehran university of medical sciences, Tehran, Iran

4 Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

5 Department of Obstetrics and Gynecology, Roointan-Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Background & Objective: Immunosuppression, HPV persistence, and smoking are the main related risk factors of cervical intraepithelial neoplasia (CIN) recurrence. However, age as a basic factor may be a main factor related to CIN recurrence. Therefore, our study aimed to detect the potential role of women's age in CIN recurrence.
Materials & Methods: This cross-sectional study was conducted on 329 patients who underwent conization in the gynecology-oncology clinics of Arash and Imam Khomeini hospitals affiliated with Tehran University of Medical Sciences between February 2016 and February 2021.
Results: Totally, 329 cases were enrolled in the study. Most women were in their thirties. CIN recurrence was about 10.0% (32 cases). The CIN recurrence rate was 8.9% in women younger than 30, 10.2% in 30-40, 11.3% in 40-50, and 5.6% in 50-60 decades. There was no significant (p-value=0.802) difference in recurrence rate among age groups. There was a significant (p-value=0.023) difference in the frequency of endocervical involvement regarding age category, women aged 40 to 50 had the most frequent marginal involvement with 26.8%, while there was no significant (p-value=0.802) difference in frequency of marginal involvement regards age category.
Conclusion: CIN cases with age higher than 40 years need to have more caution and tight follow-up visit after conization.

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