Forough Javanmanesh; Maryam Kashanian; Vajihe Zamani; Narges Sheikhansari
Volume 3, Issue 3 , September and October 2018, , Pages 99-103
Abstract
Aims: Pain is the main concern after surgery. Gabapentin was recently suggested as a pain killer to be used after various surgeries. The purpose of the present study was to evaluate the effects of gabapentin on pain relief and need for opiates after total abdominal hysterectomy.
Materials & Methods: This ...
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Aims: Pain is the main concern after surgery. Gabapentin was recently suggested as a pain killer to be used after various surgeries. The purpose of the present study was to evaluate the effects of gabapentin on pain relief and need for opiates after total abdominal hysterectomy.
Materials & Methods: This randomized double-blind placebo-controlled clinical trial was performed on 85 women who underwent total abdominal hysterectomy from March 2014 to March 2016 in Akbarabadi teaching hospital and Firoozgar teaching hospital in Tehran, Iran. Samples were selected using consecutive sampling method and were randomly assigned into the 2 groups. In case group (n=44) gabapentin (800mg) was orally administered one hour before surgery and in the placebo group (n=41) placebo which was similar to gabapentin administered. The pain score was assessed in 2, 6, 12 and 24 hours after surgery. Nausea and vomiting were also compared between the 2 groups. Data were analyzed by SPSS 19 software using statistical tests.
Findings: The two groups did not have significant differences according to pain score in the recovery room (point 0). Mean score of pain was lower in the case group in 2, 6, 12 and 24 hours after surgery (p=0.005). Meperidine (pethidine) use was less in the case group (p=0.003). There was no difference between the 2 groups for nausea and vomiting.
Conclusion: Using gabapentin before surgery can lower the pain after surgery and reduces the need for opiates. However, it doesn’t have an effect on nausea and vomiting.
Forough Javanmanesh; Mina Moeini
Volume 3, Issue 3 , September and October 2018, , Pages 133-135
Abstract
Introduction: Heterotopic pregnancy or combination of intra and extra- uterine pregnancy is very rare, but its incidence increased sharply in recent years due to the development of medically assisted reproductive technology. This condition carries a significant maternal morbidity and mortality due to ...
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Introduction: Heterotopic pregnancy or combination of intra and extra- uterine pregnancy is very rare, but its incidence increased sharply in recent years due to the development of medically assisted reproductive technology. This condition carries a significant maternal morbidity and mortality due to the risk of rupture of ectopic pregnancy. This study was a case report of heterotopic pregnancy.
Patient Information A 25 year old pregnant woman with abdominal pain and nausea and vomiting was admitted in 12 March 2018 in Firoozgar hospital that ultrasound examination suggested heterotopic pregnancy and laparotomy and left salpingectomy was performed, and intrauterine pregnancy continued. Conclusion A high index of suspicion can help in timely diagnosis and appropriate intervention and decrease the risk of complications and maternal mortality.
Forough Javanmanesh; Maryam Kashanian; Sara Mirpang
Volume 3, Issue 2 , May and June 2018, , Pages 49-52
Abstract
Aims: The rate of induced abortion is growing worldwide. In this study, we aimed at comparing using misoprostol with or without Letrozole in abortion.
Materials and Methods: In this placebo-controlled trial, 46 women with a gestational age of fewer than 20 weeks, who were candidates of legal abortion, ...
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Aims: The rate of induced abortion is growing worldwide. In this study, we aimed at comparing using misoprostol with or without Letrozole in abortion.
Materials and Methods: In this placebo-controlled trial, 46 women with a gestational age of fewer than 20 weeks, who were candidates of legal abortion, were selected by simple randomization sampling method and randomly assigned into two groups. Drug group received 10mg daily Letrozole (4 tablets of 2.5mg) for 3 days prior to taking Misoprostol and the placebo group received daily placebo (4 tablets with the exact appearance of Letrozole) with the same instructions. After 3 days, Misoprostol was given to all the participants based on their gestational ages. The data were analyzed by SPSS 16 software, using independent sample t-test and Chi-square test.
Findings: 21 women (45.7%) had a successful complete abortion, and curettage was needed for 25 women (54.3%). Successful abortion rate was significantly higher in the group receiving Letrozole (78.3%) than the group receiving placebo (13.0%; p=0.0001). Mean induction-abortion interval was 22.61±7.721 hours in the drug group and 24.09±8.251 hours in the placebo group, which was not significantly different (p>0.05). There was no significant difference between the two groups in terms of vaginal bleeding and adverse effects.
Conclusion: Using 10mg daily Letrozole for 3 days followed by oral Misoprostol results in a significantly higher rate of complete abortion compared with placebo in women with a gestational age of less than 20 weeks.
