Gynecology Oncology
Fatemeh Shafizadeh; Sara Babazadeh; Fatemeh Nasiri Amiri; Ahmadreza Shafizadeh
Volume 6, Issue 4 , August 2021, , Pages 233-238
Abstract
Mature cystic teratomas, also named dermoid cysts, are the most benign ovarian germ cell tumors and can occur in any age group. Transformation of the mature elements within the dermoid cyst to the malignancy termed mature cystic teratomas (MCTs) with malignant transformation occurs in only 1-2 % of cases. ...
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Mature cystic teratomas, also named dermoid cysts, are the most benign ovarian germ cell tumors and can occur in any age group. Transformation of the mature elements within the dermoid cyst to the malignancy termed mature cystic teratomas (MCTs) with malignant transformation occurs in only 1-2 % of cases. Of these, squamous cell carcinoma (SCC) with 80% prevalence is the most common type. A 54-year-old peri-menopausal woman -gravida 5, para 4, live 4, and abortion 1- presented to our clinic with a complaint of abdominal pain for about five months. Transvaginal ultrasonography revealed a mass with a diameter of 125-millimeter in the left adnexa with a complex appearance containing fine-echo liquid, solid internal component, and thickened wall. Spiral CT scan of abdomen & pelvis showed 147×121-millimeter bilocular lesion consistent with an ovarian dermoid cyst. Left salpingo-oophorectomy was performed, and a frozen section was requested during the surgery, which showed a malignant epithelial tumor consistent with squamous cell carcinoma arising in teratoma. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic lymphadenectomy, and partial omentectomy were done successfully. The patient was discharged from the hospital after two days without any complaints or adverse events. Regarding the rarity of MCT with malignant transformation, it is recommended to consider patient characteristics, preoperative imaging, laboratory evaluations, and the results of the frozen section during surgery since they can significantly change the treatment plan and the prognosis of the patient.
Abed Ebrahimi; Frogh Pourgholam; Mahbobeh Rostami; Farzad Abaszadeh; Behzad Gholamveisi
Volume 4, Issue 4 , September and October 2019, , Pages 155-159
Abstract
Background & Objective: Mature cystic teratomas are rare neoplasms and consist of at least two to three embryonic layers. While these tumors are most commonly seen in the testes and ovaries, they have been reported elsewhere.
Case Report: A 22-year-old female patient referred to Mehr Hospital in ...
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Background & Objective: Mature cystic teratomas are rare neoplasms and consist of at least two to three embryonic layers. While these tumors are most commonly seen in the testes and ovaries, they have been reported elsewhere.
Case Report: A 22-year-old female patient referred to Mehr Hospital in Mashhad with symptoms of pelvic pain, tympanites, altered bowel habits, nausea, and vomiting. According to the performed examinations and evaluations, a mass of 37 × 20 mm was found in the retroperitoneum between the vagina and rectum. The patient underwent laparoscopic surgery and the cyst was completely resected. The patient was discharged a day after the surgery and no surgical complications were reported in conducted follow-ups. The pathologic finding also reported a dermoid cyst.
Conclusion: Resection surgery is the mainstay in the treatment of mature retroperitoneal teratomas. Although tumor characteristics can be diagnosed preoperatively by imaging modalities, a definitive diagnosis can only be made by histologic evaluations.
Azar Ahmadzadeh; Nahid Shahbazian; Boshra Arkavazi
Volume 3, Issue 1 , March and April 2018, , Pages 19-22
Abstract
Aims Tumor markers are very applicable for examining differential diagnoses of adenosine masses. Increases in CA 19-9 have been reported in epithelial ovarian and endometrial tumors. Dermoid cysts are the most prevalent ovarian germ cell tumors. The aim of the present study was to examine Cancer Antigen ...
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Aims Tumor markers are very applicable for examining differential diagnoses of adenosine masses. Increases in CA 19-9 have been reported in epithelial ovarian and endometrial tumors. Dermoid cysts are the most prevalent ovarian germ cell tumors. The aim of the present study was to examine Cancer Antigen 19-9 (CA 19-9) tumor marker in ovarian dermoid cysts.
Information and Methods This descriptive-analytic study was conducted using hospital records. By referring to archives of a Imam Khomeini Hospital, Ahwaz, Iran in 2016, the information of 73 patients with ovarian dermoid cysts were extracted that include their demographic information, cyst size, the location of involvement, the presence of symptoms of malignancy in sonography reports, and CA 19-9 serum levels prior to surgery. A pathologic report was used for the final mass diagnosis and determining the type of mass extracted from the patients’ bodies. Data were analyzed by SPSS 22 software using independent-sample t-test, chi-square test and Pearson correlation coefficient.
Findings All patients under study were diagnosed with dermoid cysts. In 9 patients (12.85%), symptoms of malignancy were reported in their sonography reports. The mean serum levels of CA 19-9 tumor marker was 46.13±11.65U/ml. There was a direct correlation between mass size and CA 19-9 serum concentrations (r=0.24). In 20% of the patients, the concentrations of CA 19-9 were normal.
Conclusion The CA 19-9 serum concentration is related to tumor size in cases of mature cystic teratoma. In most cases of unilateral mature cystic teratomas, the right ovary is mainly preferred to involve.
Atefeh Moridi; Maliheh Arab; Ghazaleh Fazli; Maryam Khayamzadeh
Volume 1, Issue 3 , November and December 2016
Abstract
Dermoid cyst is a benign and common ovarian neoplasm affecting women. Sources for this review article were taken from PubMed and other up-to-date databases covering the period from Jan 2010 to Jan 2016. Keywords for the search were “dermoid cyst” and “treatment”. A search of the ...
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Dermoid cyst is a benign and common ovarian neoplasm affecting women. Sources for this review article were taken from PubMed and other up-to-date databases covering the period from Jan 2010 to Jan 2016. Keywords for the search were “dermoid cyst” and “treatment”. A search of the literature revealed 113 full text manuscripts, from which 21 were relevant. In addition, another 56 relevant manuscripts identified in the reference lists of the above-mentioned 21 manuscripts were included in the study, although they had been published before 2010. Clinical considerations for dermoid cyst management are categorized as follows: 1) selection of the best choice of surgical treatment in dermoid cyst: laparoscopy or laparotomy; 2) procedure to exteriorize a dermoid cyst in laparoscopy; 3) selection of oophorectomy or cystectomy; 4) spillage of the cyst contents: prevention and treatment of the consequences if it does happen; 5) necessity of surgical treatment in dermoid cyst management; 6) ovarian torsion and other complications; 7) Probability of malignancy in dermoid cyst.
