Iranian Society of Gynecology Oncology


1 Department of Obstetrics and Gynecology, Preventative Gynecology Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

2 Department of Obstetrics and Gynecology, Kashan University of Medical Sciences, Kashan, IR Iran

3 Department of Pathology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran

4 Department of Obstetrics and Gynecology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran


Background and Objective: Most gestational trophoblastic neoplasias (GTN) develop following hydatidiform mole; but may occur after abortion, normal pregnancy or even ectopic pregnancy.
Objectives: The aim of this study was to assess the importance of six-month follow-up of uncomplicated molar pregnancy after achieving undetectable β-human chorionic gonadotropin (β-hCG) levels.
Methods: In this retrospective study, molar pregnancies with negative β-hCG were compared with those with positive β-hCG during a six-month follow-up.
Results: A total of 279 women with molar pregnancy, treated at two referral university hospitals in Tehran were analyzed and 86 patients (31%) who had completed their follow-up period were included. Of the evaluated patients (n = 86), the pathology report indicated complete mole for 66 patients (77%) and partial mole for 20 patients (23%). All 86 patients had achieved at least one undetectable β-hCG level during their follow up, and none showed evidence of relapse.
Conclusions: We found that in patients with uncomplicated molar pregnancy, relapse is unlikely after achieving undetectable serum β-hCG levels. Further investigations with larger sample sizes and preferably prospective design are needed to make a definite conclusion.


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