Iranian Society of Gynecology Oncology

Document Type : Original Research Article

Authors

1 Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Preventative Gynecology Research Center, Universal Scientific Education and Research Network (USERN), Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Department of Obstetrics and Gynecology, Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Department of Cell and Molecular Biology, School of Biological Sciences, Kharazmi University, Tehran, Iran

5 Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Background and Objective: Uterine fibroids (UFs) the most common pelvic tumors among women at reproductive age affecting women’s quality of life even their confidence with its symptoms. We designed a study to investigate the clinical, laboratory, and imaging characteristics of Iranian women with UF.
Methods: This cross-sectional study was performed April 2016- September 2022 at Imam Hossein hospital (Tehran, Iran). We included all women with UF referring to the Obstetrics and Gynecology Clinic of Imam Hossein Hospital. Based on a checklist a research team interviewed the patients to investigate clinical characteristics. Also we explored laboratory and transvaginal sonography (TVS) findings of all patients.
Results: The mean age of 439 studied patients was 44.47±8.80 years (range: 23-81). The most prevalent underlying disease was hypertension (17.1%), followed by thyroid diseases (15.7%) and diabetes mellitus (13.7%). The patients mainly complained of AUB (abnormal menstrual bleeding) (60.0%), abdominal pain (23.7%). The mean NLR (neutrophil to lymphocyte ratio) and the mean PLR (platelet to lymphocyte ratio) were significantly higher than the normal upper limit (P<0.001). Largest diameter of UF was 49.89±47.92 mm. Most fibroids were located anteriorly (43.1%). The multivariate linear regression model revealed that age (β=-0.931, 95%CI= (-1.657, -0.204), P=0.012) and number of fibroid (β=22.418, 95%CI= (16.360, 28.476), P<0.001) could predict the size of fibroid.
Conclusion: Our results showed that NLR and PLR were increased in UF patients. It seems that patient’s age and number of fibroid may be the predict factors for UF's size.
Keywords: Abnormal Uterine Bleeding, hypertension, Neutrophil, Leiomyoma, Lymphocyte, Ultrasonography.

Keywords

Main Subjects

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