Pathology
Fereshteh Ameli; Maryam Entezarian; Noraidah Masir; Tan Geok Chin
Volume 9, Issue 1 , January and February 2024, , Pages 7-13
Abstract
Background & Objective: The highest mortality rate in gynecologic cancers is attributed to ovarian origin. Expression of the estrogen and progesterone receptors (ER and PR); and Human epidermal growth factor receptor 2 (Her2/neu) in endometrial cancer and breast cancer were found to be associated ...
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Background & Objective: The highest mortality rate in gynecologic cancers is attributed to ovarian origin. Expression of the estrogen and progesterone receptors (ER and PR); and Human epidermal growth factor receptor 2 (Her2/neu) in endometrial cancer and breast cancer were found to be associated with the response to treatment and prognosis. However, because of inconsistent results from previous studies, the data regarding ovarian cancer are still inconclusive.Materials & Methods: Current retrospective cross-sectional study was performed on 234 tissue samples of different types of ovarian tumors (benign, borderline and malignant) from the archive of the University Kebangsaan Malaysia Medical Center during 10 years. Tissue microarrays were constructed on representative areas from formalin fixed paraffin embedded tissue blocks using ER, PR and HER2 immunohistochemical staining.Results: Prevalence of ER and PR overexpression was 36% and 35% in benign, 8% and 24% in borderline tumors with 51% and 46% in malignant tumors, respectively. ERα overexpression was more common among serous malignant ovarian tumors (49%) (p<0.001). PR positivity was more prevalent in serous benign tumors (p=0.02).There was no significant relationship between stage and the status of ERα (p=0.12) and PR (p=0.19). Her2/neu overexpression was only seen in borderline neoplasms (8%) and malignant mucinous tumors (4%). No association was found between Her2/neu overexpression and the level of tumor differentiation, tumor stage, size, and patient’s age.Conclusion: The observed ERα positivity in serous carcinoma and Her2/neu overexpression in malignant mucinous tumor, could be considered as a clue for choosing therapeutic agents. The role of anti-HER2 therapy in clear cell carcinoma is still debated and needs more investigations.
General Gynecology and Pelvic Floor
Behnaz Nouri; Ladan Ajori; Zohreh Ahmadvand; Saba Fahimhi
Volume 8, Issue 6 , November and December 2023, , Pages 614-619
Abstract
Background & Objective: Adnexal torsion is a complete or incomplete twisting of the ovary, fallopian tubes, or ovarian cyst around its vascular axis, which can cause blood flow disruption. This disorder is rare but serious and accounts for about 3% of women's emergency surgeries. Early diagnosis ...
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Background & Objective: Adnexal torsion is a complete or incomplete twisting of the ovary, fallopian tubes, or ovarian cyst around its vascular axis, which can cause blood flow disruption. This disorder is rare but serious and accounts for about 3% of women's emergency surgeries. Early diagnosis of this disease and the necessary surgeries are very important to preserve fertility. The purpose of this study is to investigate the epidemiology, clinical symptoms, imaging and pathology of patients with torsion of the adnexa referred to the emergency rooms of Mahdiyeh and Shohadaye Tajrish hospitals.Materials & Methods: This study is a retrospective cross-sectional study. In the present study, 190 patients with torsion of the adnexa were examined in the period 2011–2021, in Mahdiyeh and Shohadaye Tajrish hospitals. Demographic, clinical and surgical information about patients was extracted from medical records. Data analysis was done using SPSS version 22 statistical software.Results: The average age of 190 patients was 29.2. Most of the ovarian torsion patients had a history of more than one previous delivery (57.9%) and also, an ovarian mass was observed in 157 patients, and the ovarian mass of 146 patients was larger than 5 cm. The rate of ovarian preservation in this study was 61%. Hemorrhagic cysts were the most common type of cyst in patients and were reported in 37 patients.Conclusion: It is necessary to identify effective diagnostic methods. Therefore, it may be useful to investigate more serum biomarkers for early detection of adnexal torsion and to reduce diagnostic errors.
Pathology
Nahid Ghanbarzadeh; Ali Nadjfai-Semnani; Mohammad Nadjafi-Semnani; Mahmoodreza Behravan; Majid Zare-Bidaki
Volume 8, Issue 2 , March and April 2023, , Pages 184-187
Abstract
Echinococcus granulosus (sensu lato) is the main cause of Cystic hydatid in human and livestock in the world and is considered a neglected tropical disease. Hydatid cysts often form in the liver (50–70%) and less frequently the lung, spleen, kidney, bone, brain and genital system. Ovarian hydatid ...
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Echinococcus granulosus (sensu lato) is the main cause of Cystic hydatid in human and livestock in the world and is considered a neglected tropical disease. Hydatid cysts often form in the liver (50–70%) and less frequently the lung, spleen, kidney, bone, brain and genital system. Ovarian hydatid cyst is one of the rarest cases with nonspecific clinical presentation. Here in a case report study, we report a primary unilateral ovarian hydatid cyst in a 45-years-old woman. This patient was presented with a large pelvic mass. A pelvic multiloculated mass in abdominal ultrasound and a solid-cystic lesion of the left adnexa in CT scan were reported. All other laboratory tests and chest X-ray showed typical results. Molecular method was performed to confirm radiography and staining methods. A cystic mass on the left fallopian tube and ovary was found in the patient's laparotomy and all were resected with the appearance of a tubo-ovarian abscess. Postoperative pathological and molecular diagnosis confirmed a hydatid cyst disease. Five years of follow-up revealed no recurrence of the disease. Hydatid cyst can.
Pathology
Tajossadat Allameh; Behnoosh Mohamadi
Volume 8, Issue 1 , January and February 2023, , Pages 76-80
Abstract
Signet ring stromal tumor is a rare benign ovarian neoplasm, of which only about 17 cases have been reported since 1996. The signet ring appearance of this tumor may mimic a Krukenberg tumor and result in a diagnostic challenge in some cases. The previous cases occurred in adult or in old patients. We ...
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Signet ring stromal tumor is a rare benign ovarian neoplasm, of which only about 17 cases have been reported since 1996. The signet ring appearance of this tumor may mimic a Krukenberg tumor and result in a diagnostic challenge in some cases. The previous cases occurred in adult or in old patients. We have reporteda Signet ring stromal tumor in a 13-year-old girl.
Gynecology Oncology
Shahrzad Sheikhhasani; Mohades Peydayesh; Narges Zamani; Somayeh Nikfar; Mona Mohseni
Volume 7, Issue 4 , March and April 2022, , Pages 348-350
Abstract
Perivascular epithelioid cell tumors (PEComas) are a group of mesenchymal neoplasms with different biological presentations from benign to malignant types. Hence, we report the first description of PEComa presenting with an acute surgical abdomen. Her definite diagnoses were made based on the histomorphology ...
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Perivascular epithelioid cell tumors (PEComas) are a group of mesenchymal neoplasms with different biological presentations from benign to malignant types. Hence, we report the first description of PEComa presenting with an acute surgical abdomen. Her definite diagnoses were made based on the histomorphology results at Imam Khomeini Hospital, Tehran University of Medical Sciences, in 2020.Considering different clinical presentations, unknown characteristics of imaging, and rarity of PEComa, preoperative diagnosis of it seems impossible. However, IHC can play an important role in its diagnosis.
Malihe Hasanzadeh; Estak Rezaee
Volume 3, Issue 3 , September and October 2018, , Pages 129-131
Abstract
Introduction: Swyer syndrome is determined by primary amenorrhea, normal external genitalia, and the presence of a vagina, uterus, and 46XY karyotype. The aim of this case report was to introduce a patient with Swyer syndrome referred with pain and an abdominal mass.
Patient Information: This case study ...
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Introduction: Swyer syndrome is determined by primary amenorrhea, normal external genitalia, and the presence of a vagina, uterus, and 46XY karyotype. The aim of this case report was to introduce a patient with Swyer syndrome referred with pain and an abdominal mass.
Patient Information: This case study was done in Gynecology Clinic of Ghaem Hospital in Mashhad, Iran, in 2015. A single 18-year-old woman came to the clinic with complaints of primary amenorrhea, pain, and abdominal mass underwent laparotomy. Based on her histopathology report which indicated a left ovary dysgerminoma and a right ovary gonadoblastoma, a bilateral salpingo-oophorectomy, followed by chemotherapy, was conducted. The patient was under Bleomycin, Etoposide and Platinum (BEP) chemotherapy and has been living without evidence of recurrence.
Conclusion: A genetic disorder in patients younger than 20 years with an ovarian mass and diagnosis of dysgerminoma should be rejected.
Atefeh Moridi; Maliheh Arab; Ghazaleh Fazli; Maryam Khayamzadeh
Volume 1, Issue 3 , November and December 2016
Abstract
Dermoid cyst is a benign and common ovarian neoplasm affecting women. Sources for this review article were taken from PubMed and other up-to-date databases covering the period from Jan 2010 to Jan 2016. Keywords for the search were “dermoid cyst” and “treatment”. A search of the ...
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Dermoid cyst is a benign and common ovarian neoplasm affecting women. Sources for this review article were taken from PubMed and other up-to-date databases covering the period from Jan 2010 to Jan 2016. Keywords for the search were “dermoid cyst” and “treatment”. A search of the literature revealed 113 full text manuscripts, from which 21 were relevant. In addition, another 56 relevant manuscripts identified in the reference lists of the above-mentioned 21 manuscripts were included in the study, although they had been published before 2010. Clinical considerations for dermoid cyst management are categorized as follows: 1) selection of the best choice of surgical treatment in dermoid cyst: laparoscopy or laparotomy; 2) procedure to exteriorize a dermoid cyst in laparoscopy; 3) selection of oophorectomy or cystectomy; 4) spillage of the cyst contents: prevention and treatment of the consequences if it does happen; 5) necessity of surgical treatment in dermoid cyst management; 6) ovarian torsion and other complications; 7) Probability of malignancy in dermoid cyst.
